hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04317.1
Complex Portal: CPX-17261
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TREML1 | Trem-like transcript 1 protein (TLT-1) (Triggering receptor expressed on myeloid cells-like protein 1) | 5 | UniProt NCBI |
| ALDOC | Fructose-bisphosphate aldolase C (EC 4.1.2.13) (Brain-type aldolase) | 5 | UniProt NCBI |
| ALDOA | Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase) | 5 | UniProt NCBI |
| ALDOB | Fructose-bisphosphate aldolase B (EC 4.1.2.13) (Liver-type aldolase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0004332 | 3.84480164306e-07 | 0.75 | ALDOA ALDOC ALDOB | fructose-bisphosphate aldolase activity |
| KEGG:00030 | 1.0028742148e-06 | 0.75 | ALDOA ALDOC ALDOB | Pentose phosphate pathway |
| KEGG:00051 | 2.05095399953e-06 | 0.75 | ALDOA ALDOC ALDOB | Fructose and mannose metabolism |
| WP:WP534 | 4.00454251624e-06 | 0.75 | ALDOA ALDOC ALDOB | Glycolysis and gluconeogenesis |
| REAC:R-HSA-70263 | 4.0993398561e-06 | 0.75 | ALDOA ALDOC ALDOB | Gluconeogenesis |
| GO:0016832 | 7.68841921772e-06 | 0.75 | ALDOA ALDOC ALDOB | aldehyde-lyase activity |
| KEGG:00010 | 1.2943754201e-05 | 0.75 | ALDOA ALDOC ALDOB | Glycolysis / Gluconeogenesis |
| KEGG:01230 | 1.63910874597e-05 | 0.75 | ALDOA ALDOC ALDOB | Biosynthesis of amino acids |
| WP:WP4018 | 2.35146163933e-05 | 0.75 | ALDOA ALDOC ALDOB | Clear cell renal cell carcinoma pathways |
| GO:0006000 | 3.22863876272e-05 | 0.75 | ALDOA ALDOC ALDOB | fructose metabolic process |
| GO:0030388 | 3.22863876272e-05 | 0.75 | ALDOA ALDOC ALDOB | fructose 1,6-bisphosphate metabolic process |
| HP:0012545 | 3.34429085774e-05 | 0.5 | ALDOA ALDOB | Reduced circulating aldolase concentration |
| WP:WP5355 | 3.5618246416e-05 | 0.75 | ALDOA ALDOC ALDOB | Metabolic Epileptic Disorders |
| KEGG:04066 | 5.35787298046e-05 | 0.75 | ALDOA ALDOC ALDOB | HIF-1 signaling pathway |
| REAC:R-HSA-70171 | 6.1097260824e-05 | 0.75 | ALDOA ALDOC ALDOB | Glycolysis |
| KEGG:01200 | 6.21896513057e-05 | 0.75 | ALDOA ALDOC ALDOB | Carbon metabolism |
| REAC:R-HSA-70326 | 0.000110531761496 | 0.75 | ALDOA ALDOC ALDOB | Glucose metabolism |
| GO:0016830 | 0.0025122894873 | 0.75 | ALDOA ALDOC ALDOB | carbon-carbon lyase activity |
| REAC:R-HSA-71387 | 0.00382744839761 | 0.75 | ALDOA ALDOC ALDOB | Metabolism of carbohydrates |
| HP:0012400 | 0.0092117244708 | 0.5 | ALDOA ALDOB | Abnormal circulating aldolase concentration |
| GO:0046032 | 0.0167406494658 | 0.75 | ALDOA ALDOC ALDOB | ADP catabolic process |
| GO:0006096 | 0.0167406494658 | 0.75 | ALDOA ALDOC ALDOB | glycolytic process |
| GO:0046031 | 0.0175369202004 | 0.75 | ALDOA ALDOC ALDOB | ADP metabolic process |
| GO:0009181 | 0.0183580179548 | 0.75 | ALDOA ALDOC ALDOB | purine ribonucleoside diphosphate catabolic process |
| GO:0009137 | 0.0183580179548 | 0.75 | ALDOA ALDOC ALDOB | purine nucleoside diphosphate catabolic process |
| GO:0019364 | 0.0192043220783 | 0.75 | ALDOA ALDOC ALDOB | pyridine nucleotide catabolic process |
| GO:0009179 | 0.0192043220783 | 0.75 | ALDOA ALDOC ALDOB | purine ribonucleoside diphosphate metabolic process |
| GO:0009135 | 0.0200762118412 | 0.75 | ALDOA ALDOC ALDOB | purine nucleoside diphosphate metabolic process |
| GO:0009191 | 0.0209740664347 | 0.75 | ALDOA ALDOC ALDOB | ribonucleoside diphosphate catabolic process |
| GO:0072526 | 0.0218982649712 | 0.75 | ALDOA ALDOC ALDOB | pyridine-containing compound catabolic process |
| GO:0009134 | 0.0228491864842 | 0.75 | ALDOA ALDOC ALDOB | nucleoside diphosphate catabolic process |
| GO:0009185 | 0.0269276802074 | 0.75 | ALDOA ALDOC ALDOB | ribonucleoside diphosphate metabolic process |
| GO:0009132 | 0.0314640437065 | 0.75 | ALDOA ALDOC ALDOB | nucleoside diphosphate metabolic process |
| GO:0006090 | 0.0420072408269 | 0.75 | ALDOA ALDOC ALDOB | pyruvate metabolic process |
| GO:0070061 | 0.042122686785 | 0.5 | ALDOA ALDOB | fructose binding |
| GO:0009154 | 0.048062454325 | 0.75 | ALDOA ALDOC ALDOB | purine ribonucleotide catabolic process |
| WP:WP690 | 0.049746753544 | 0.25 | ALDOB | Polyol pathway |
| REAC:R-HSA-5657560 | 0.0499436884912 | 0.25 | ALDOB | Hereditary fructose intolerance |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ALDOC | ALDOA | 0.999 | 0.78 |
mutually_exclusive (P05062)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction treiber_WMM |
| ALDOB | TREML1 | 0.996 | bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| ALDOA | ALDOB | 0.994 | 0.298 |
mutually_exclusive (P09972)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ALDOC | ALDOB | 0.987 | 0.174 |
mutually_exclusive (P04075)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex3_WMM WMM_only |
| ALDOC | TREML1 | 0.003 | bioplex3_HCT116 WMM_only | ||
| ALDOA | TREML1 | 0.003 | bioplex3_HCT116 WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| TREML1 | huMAP3_04317.1 huMAP3_06225.1 huMAP3_12505.1 |
| ALDOC | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| ALDOA | huMAP3_01143.1 huMAP3_04317.1 huMAP3_12505.1 |
| ALDOB | huMAP3_01143.1 huMAP3_04317.1 huMAP3_06225.1 huMAP3_12505.1 |