hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04325.1

Complex Portal: CPX-15289

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
WDR87	WD repeat-containing protein 87 (Testis development protein NYD-SP11)	3	UniProt NCBI
HDAC3	Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) (RPD3-2) (SMAP45)	5	UniProt NCBI
SETD5	Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)	5	UniProt NCBI
NCOR1	Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)	5	UniProt NCBI
TBL1Y	F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)	5	UniProt NCBI
TBL1XR1	F-box-like/WD repeat-containing protein TBL1XR1 (Nuclear receptor corepressor/HDAC3 complex subunit TBLR1) (TBL1-related protein 1) (Transducin beta-like 1X-related protein 1)	5	UniProt NCBI
ANKRD11	Ankyrin repeat domain-containing protein 11 (Ankyrin repeat-containing cofactor 1)	5	UniProt NCBI
GPS2	G protein pathway suppressor 2 (GPS-2)	5	UniProt NCBI
TBL1X	F-box-like/WD repeat-containing protein TBL1X (SMAP55) (Transducin beta-like protein 1X) (Transducin-beta-like protein 1, X-linked)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:741	1.84180722403e-15	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	NCOR-HDAC3 complex
CORUM:15	1.10483220475e-14	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	NCOR complex
REAC:R-HSA-9022537	3.22548169728e-14	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Loss of MECP2 binding ability to the NCoR/SMRT complex
CORUM:2183	4.63606134522e-13	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Kaiso-NCOR complex
REAC:R-HSA-9675151	1.35346625055e-12	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Disorders of Developmental Biology
REAC:R-HSA-9697154	1.35346625055e-12	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Disorders of Nervous System Development
REAC:R-HSA-9005895	1.35346625055e-12	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Pervasive developmental disorders
REAC:R-HSA-9005891	1.35346625055e-12	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Loss of function of MECP2 in Rett syndrome
CORUM:58	2.69032781214e-11	0.444444444444	HDAC3 TBL1X TBL1XR1 GPS2	SMRT complex
REAC:R-HSA-9022692	6.35059719407e-10	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Regulation of MECP2 expression and activity
REAC:R-HSA-9029569	9.0820881057e-10	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
REAC:R-HSA-9024446	3.07191674153e-09	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	NR1H2 and NR1H3-mediated signaling
REAC:R-HSA-8986944	1.52620946243e-08	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Transcriptional Regulation by MECP2
GO:0000118	2.30518753512e-08	0.666666666667	HDAC3 TBL1XR1 TBL1Y SETD5 TBL1X NCOR1	histone deacetylase complex
REAC:R-HSA-350054	1.14373512426e-07	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Notch-HLH transcription pathway
REAC:R-HSA-3214815	1.27066333918e-07	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	HDACs deacetylate histones
REAC:R-HSA-1989781	3.76401385349e-07	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	PPARA activates gene expression
REAC:R-HSA-400206	3.96121142134e-07	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Regulation of lipid metabolism by PPARalpha
WP:WP4312	6.70159706378e-07	0.444444444444	NCOR1 TBL1X TBL1XR1 GPS2	Rett syndrome causing genes
REAC:R-HSA-9609690	9.98125265684e-07	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	HCMV Early Events
REAC:R-HSA-2122947	1.4218926471e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	NOTCH1 Intracellular Domain Regulates Transcription
REAC:R-HSA-9707616	1.74050956917e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Heme signaling
REAC:R-HSA-9609646	2.33488700563e-06	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	HCMV Infection
REAC:R-HSA-2644603	2.76977126814e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Signaling by NOTCH1 in Cancer
REAC:R-HSA-2894858	2.76977126814e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
REAC:R-HSA-2894862	2.76977126814e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
REAC:R-HSA-2644606	2.76977126814e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Constitutive Signaling by NOTCH1 PEST Domain Mutants
REAC:R-HSA-2644602	2.76977126814e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Signaling by NOTCH1 PEST Domain Mutants in Cancer
REAC:R-HSA-2151201	3.0207398275e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Transcriptional activation of mitochondrial biogenesis
GO:0017053	5.13607866526e-06	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	transcription repressor complex
GO:0003714	6.16717057768e-06	0.666666666667	HDAC3 TBL1XR1 TBL1Y TBL1X NCOR1 GPS2	transcription corepressor activity
REAC:R-HSA-9707564	7.04426707928e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Cytoprotection by HMOX1
REAC:R-HSA-1980143	7.04426707928e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Signaling by NOTCH1
REAC:R-HSA-400253	8.07264008546e-06	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Circadian Clock
CORUM:5614	1.26384976661e-05	0.333333333333	HDAC3 TBL1XR1 TBL1Y	Emerin complex 32
REAC:R-HSA-381340	1.87298045635e-05	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Transcriptional regulation of white adipocyte differentiation
CORUM:5426	2.73623797451e-05	0.222222222222	HDAC3 ANKRD11	ANCO1-HDAC3 complex
REAC:R-HSA-1592230	3.26247422283e-05	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Mitochondrial biogenesis
REAC:R-HSA-9006931	3.74129569128e-05	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Signaling by Nuclear Receptors
REAC:R-HSA-4839726	3.97328560982e-05	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Chromatin organization
REAC:R-HSA-3247509	3.97328560982e-05	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Chromatin modifying enzymes
CORUM:7480	8.20609246787e-05	0.222222222222	HDAC3 NCOR1	HDAC3-H1.3-SMRT-N-Cor complex
CORUM:1188	8.20609246787e-05	0.222222222222	HDAC3 TBL1X	SMRT core complex
CORUM:752	8.20609246787e-05	0.222222222222	HDAC3 TBL1X	SMRT core complex
REAC:R-HSA-1368071	0.000239571230342	0.222222222222	HDAC3 NCOR1	NR1D1 (REV-ERBA) represses gene expression
CORUM:1505	0.000573693030134	0.222222222222	HDAC3 NCOR1	NCOR2 complex
REAC:R-HSA-9711123	0.000676305290122	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Cellular response to chemical stress
REAC:R-HSA-157118	0.00104189526307	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Signaling by NOTCH
CORUM:1413	0.00122816473062	0.222222222222	HDAC3 NCOR1	NCOR1 complex
GO:0003712	0.00203347484921	0.666666666667	HDAC3 TBL1XR1 TBL1Y TBL1X NCOR1 GPS2	transcription coregulator activity
REAC:R-HSA-556833	0.00328763935443	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Metabolism of lipids
REAC:R-HSA-1852241	0.00339962776506	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Organelle biogenesis and maintenance
KEGG:04310	0.00430102432376	0.333333333333	TBL1Y TBL1XR1 TBL1X	Wnt signaling pathway
REAC:R-HSA-9824446	0.00644900522555	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Viral Infection Pathways
REAC:R-HSA-1368082	0.00954313848115	0.222222222222	TBL1X TBL1XR1	RORA activates gene expression
REAC:R-HSA-5663202	0.0110276614435	0.444444444444	HDAC3 TBL1X TBL1XR1 NCOR1	Diseases of signal transduction by growth factor receptors and second messengers
REAC:R-HSA-5663205	0.0174507834687	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Infectious disease
REAC:R-HSA-1368108	0.0200751738188	0.222222222222	TBL1X TBL1XR1	BMAL1:CLOCK,NPAS2 activates circadian gene expression
HPA:0270352	0.0274135055716	0.777777777778	HDAC3 ANKRD11 NCOR1 SETD5 TBL1X GPS2 TBL1XR1	kidney; cells in glomeruli[>=Medium]
HPA:0490692	0.0289589517706	0.777777777778	HDAC3 ANKRD11 NCOR1 SETD5 TBL1X GPS2 TBL1XR1	smooth muscle; smooth muscle cells[>=Medium]
GO:0046329	0.0359812030822	0.333333333333	HDAC3 GPS2 NCOR1	negative regulation of JNK cascade
HPA:0270363	0.0389693299448	0.666666666667	ANKRD11 NCOR1 SETD5 TBL1X GPS2 TBL1XR1	kidney; cells in tubules[High]
REAC:R-HSA-212436	0.0395263988284	0.555555555556	HDAC3 GPS2 TBL1XR1 TBL1X NCOR1	Generic Transcription Pathway

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
NCOR1	GPS2	1.0	0.152		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
TBL1XR1	GPS2	1.0	0.166	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
GPS2	HDAC3	1.0	0.2296		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM
GPS2	TBL1X	1.0	0.082		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
ANKRD11	GPS2	0.999	0.136		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116
GPS2	TBL1Y	0.999		mutually_exclusive (Q9BZK7)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBL1X	TBL1Y	0.999		mutually_exclusive (Q9BZK7) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
NCOR1	TBL1Y	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
HDAC3	TBL1Y	0.998			bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TBL1XR1	TBL1Y	0.998		mutually_exclusive (O60907) structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
WDR87	GPS2	0.995			bioplex3_WMM bioplex3_HCT116 WMM_only
SETD5	GPS2	0.986	0.132		bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
NCOR1	TBL1XR1	0.969	0.148		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
SETD5	TBL1XR1	0.967	0.112	structurally_consistent (dimer)	hein_WMM bioplex3_WMM youn_WMM hein ()
NCOR1	HDAC3	0.959	0.28		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
ANKRD11	TBL1X	0.954	0.066		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
ANKRD11	HDAC3	0.952	0.366		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
NCOR1	TBL1X	0.95	0.154		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TBL1XR1	HDAC3	0.948	0.304		bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only
TBL1XR1	ANKRD11	0.913	0.134		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
TBL1XR1	TBL1X	0.91	0.954	mutually_exclusive (Q9BQ87) structurally_consistent (dimer)	bioplex_WMM bioplex3_WMM youn_WMM WMM_only
WDR87	ANKRD11	0.908			bioplex3_WMM WMM_only
TBL1X	HDAC3	0.892	0.4		bioplex_WMM bioplex3_WMM youn_WMM WMM_only
SETD5	ANKRD11	0.885	0.16		hein_WMM bioplex3_WMM youn_WMM hein ()
NCOR1	ANKRD11	0.885	0.242		hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only
SETD5	NCOR1	0.862	0.209		hein_WMM bioplex3_WMM youn_WMM hein ()
SETD5	WDR87	0.768			bioplex3_WMM WMM_only
WDR87	TBL1X	0.715			bioplex3_WMM WMM_only
WDR87	NCOR1	0.675			bioplex3_WMM WMM_only
WDR87	TBL1XR1	0.654			bioplex3_WMM WMM_only
WDR87	HDAC3	0.312			bioplex3_WMM WMM_only
SETD5	TBL1X	0.258	0.046		bioplex3_WMM youn_WMM WMM_only
SETD5	HDAC3	0.097	0.198		bioplex3_WMM youn_WMM WMM_only

Related Complexes

Genename	Complexes
WDR87	huMAP3_03197.1 huMAP3_04325.1 huMAP3_04657.1 huMAP3_05576.1 huMAP3_05713.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_10289.1 huMAP3_13269.1
HDAC3	huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07614.1 huMAP3_08843.1 huMAP3_10798.1
SETD5	huMAP3_00867.1 huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_07695.1 huMAP3_12111.1 huMAP3_13269.1
NCOR1	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1Y	huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1 huMAP3_14743.1
TBL1XR1	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_13269.1
ANKRD11	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07614.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
GPS2	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_06884.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1
TBL1X	huMAP3_03197.1 huMAP3_04325.1 huMAP3_05713.1 huMAP3_06120.1 huMAP3_06185.1 huMAP3_07695.1 huMAP3_08843.1 huMAP3_13269.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04325.1

Complex Portal: CPX-15289