hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04346.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| INCENP | Inner centromere protein | 5 | UniProt NCBI |
| BIRC5 | Baculoviral IAP repeat-containing protein 5 (Apoptosis inhibitor 4) (Apoptosis inhibitor survivin) | 5 | UniProt NCBI |
| CDCA8 | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1120 | 2.33868713081e-10 | 1.0 | INCENP BIRC5 CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5) |
| CORUM:1118 | 9.35474852325e-10 | 1.0 | INCENP BIRC5 CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| CORUM:1119 | 9.35474852325e-10 | 1.0 | INCENP BIRC5 CDCA8 | Chromosomal passenger complex CPC (INCENP, CDCA8, BIRC5, AURKB) |
| GO:0032133 | 1.92240082153e-06 | 1.0 | INCENP BIRC5 CDCA8 | chromosome passenger complex |
| GO:1903490 | 3.36420143768e-06 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of mitotic cytokinesis |
| REAC:R-HSA-4615885 | 5.35659258038e-06 | 1.0 | INCENP BIRC5 CDCA8 | SUMOylation of DNA replication proteins |
| GO:1902412 | 5.38272230028e-06 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic cytokinesis |
| GO:1902423 | 5.38272230028e-06 | 1.0 | INCENP BIRC5 CDCA8 | regulation of attachment of mitotic spindle microtubules to kinetochore |
| GO:1902425 | 5.38272230028e-06 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of attachment of mitotic spindle microtubules to kinetochore |
| CORUM:2582 | 1.02521027753e-05 | 0.666666666667 | BIRC5 CDCA8 | Chromosomal passenger complex CPC (CDCA8, AURKB, BIRC5) |
| CORUM:2579 | 1.02521027753e-05 | 0.666666666667 | INCENP BIRC5 | Chromosomal passenger complex CPC (INCENP, BIRC5, AURKB) |
| GO:0051256 | 1.58598067776e-05 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle midzone assembly |
| GO:0051987 | 1.58598067776e-05 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of attachment of spindle microtubules to kinetochore |
| CORUM:1087 | 2.05032700758e-05 | 0.666666666667 | INCENP BIRC5 | BIRC5-AURKB-INCENP-EVI5 complex |
| GO:0090267 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:0090235 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 CDCA8 | regulation of metaphase plate congression |
| GO:0000022 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle elongation |
| GO:0051255 | 2.11464090368e-05 | 1.0 | INCENP BIRC5 CDCA8 | spindle midzone assembly |
| GO:0090232 | 2.74903317479e-05 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of spindle checkpoint |
| GO:0051231 | 2.74903317479e-05 | 1.0 | INCENP BIRC5 CDCA8 | spindle elongation |
| REAC:R-HSA-141444 | 5.85958968853e-05 | 1.0 | INCENP BIRC5 CDCA8 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-141424 | 5.85958968853e-05 | 1.0 | INCENP BIRC5 CDCA8 | Amplification of signal from the kinetochores |
| GO:1901978 | 7.84339535184e-05 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of cell cycle checkpoint |
| GO:1901970 | 7.84339535184e-05 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of mitotic sister chromatid separation |
| GO:0090266 | 9.31403198031e-05 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic cell cycle spindle assembly checkpoint |
| GO:1903504 | 9.31403198031e-05 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic spindle checkpoint |
| REAC:R-HSA-69618 | 9.52596267282e-05 | 1.0 | INCENP BIRC5 CDCA8 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.00010924835892 | 1.0 | INCENP BIRC5 CDCA8 | EML4 and NUDC in mitotic spindle formation |
| GO:0051988 | 0.000109576846827 | 1.0 | INCENP BIRC5 CDCA8 | regulation of attachment of spindle microtubules to kinetochore |
| GO:0090231 | 0.000109576846827 | 1.0 | INCENP BIRC5 CDCA8 | regulation of spindle checkpoint |
| REAC:R-HSA-2500257 | 0.000134372084608 | 1.0 | INCENP BIRC5 CDCA8 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-5663220 | 0.000174817158202 | 1.0 | INCENP BIRC5 CDCA8 | RHO GTPases Activate Formins |
| GO:0051315 | 0.000194546963139 | 1.0 | INCENP BIRC5 CDCA8 | attachment of mitotic spindle microtubules to kinetochore |
| REAC:R-HSA-3108232 | 0.000300937850546 | 1.0 | INCENP BIRC5 CDCA8 | SUMO E3 ligases SUMOylate target proteins |
| GO:1905820 | 0.000314889254566 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of chromosome separation |
| GO:0051984 | 0.000314889254566 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of chromosome segregation |
| REAC:R-HSA-2990846 | 0.000330616079734 | 1.0 | INCENP BIRC5 CDCA8 | SUMOylation |
| REAC:R-HSA-2467813 | 0.000476579961334 | 1.0 | INCENP BIRC5 CDCA8 | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.000567791814488 | 1.0 | INCENP BIRC5 CDCA8 | Mitotic Prometaphase |
| GO:0032467 | 0.000575182325801 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of cytokinesis |
| REAC:R-HSA-68882 | 0.000850835472921 | 1.0 | INCENP BIRC5 CDCA8 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000862385275721 | 1.0 | INCENP BIRC5 CDCA8 | Mitotic Metaphase and Anaphase |
| GO:0051781 | 0.000949666005835 | 1.0 | INCENP BIRC5 CDCA8 | positive regulation of cell division |
| GO:0007094 | 0.00102463963787 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle assembly checkpoint signaling |
| GO:1901976 | 0.00102463963787 | 1.0 | INCENP BIRC5 CDCA8 | regulation of cell cycle checkpoint |
| GO:0071173 | 0.00102463963787 | 1.0 | INCENP BIRC5 CDCA8 | spindle assembly checkpoint signaling |
| GO:0071174 | 0.00102463963787 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle checkpoint signaling |
| GO:0033046 | 0.00110345807156 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of sister chromatid segregation |
| GO:0031577 | 0.00110345807156 | 1.0 | INCENP BIRC5 CDCA8 | spindle checkpoint signaling |
| GO:0033048 | 0.00110345807156 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of mitotic sister chromatid segregation |
| GO:2000816 | 0.00110345807156 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of mitotic sister chromatid separation |
| GO:0045841 | 0.00110345807156 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of mitotic metaphase/anaphase transition |
| GO:1902100 | 0.00127301382402 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of metaphase/anaphase transition of cell cycle |
| GO:1905819 | 0.00127301382402 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of chromosome separation |
| GO:0051985 | 0.00127301382402 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of chromosome segregation |
| GO:0033047 | 0.00166249223046 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic sister chromatid segregation |
| REAC:R-HSA-69620 | 0.00167079914838 | 1.0 | INCENP BIRC5 CDCA8 | Cell Cycle Checkpoints |
| GO:0045839 | 0.00177091563679 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of mitotic nuclear division |
| GO:0008608 | 0.0018839528051 | 1.0 | INCENP BIRC5 CDCA8 | attachment of spindle microtubules to kinetochore |
| REAC:R-HSA-195258 | 0.00199644124929 | 1.0 | INCENP BIRC5 CDCA8 | RHO GTPase Effectors |
| GO:0051784 | 0.00212425290779 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of nuclear division |
| GO:0010965 | 0.00212425290779 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic sister chromatid separation |
| GO:0051306 | 0.00238416149886 | 1.0 | INCENP BIRC5 CDCA8 | mitotic sister chromatid separation |
| GO:0007080 | 0.0028124724019 | 1.0 | INCENP BIRC5 CDCA8 | mitotic metaphase chromosome alignment |
| GO:0090307 | 0.00345936027834 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle assembly |
| GO:1905818 | 0.00439845307966 | 1.0 | INCENP BIRC5 CDCA8 | regulation of chromosome separation |
| REAC:R-HSA-68886 | 0.00447254250064 | 1.0 | INCENP BIRC5 CDCA8 | M Phase |
| GO:0051304 | 0.0057325992498 | 1.0 | INCENP BIRC5 CDCA8 | chromosome separation |
| GO:0032465 | 0.00597828207479 | 1.0 | INCENP BIRC5 CDCA8 | regulation of cytokinesis |
| GO:0000281 | 0.00789722257484 | 1.0 | INCENP BIRC5 CDCA8 | mitotic cytokinesis |
| GO:0030071 | 0.00851239083773 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic metaphase/anaphase transition |
| GO:1902099 | 0.00915870199393 | 1.0 | INCENP BIRC5 CDCA8 | regulation of metaphase/anaphase transition of cell cycle |
| GO:0007091 | 0.00983692500376 | 1.0 | INCENP BIRC5 CDCA8 | metaphase/anaphase transition of mitotic cell cycle |
| GO:2001251 | 0.0101882437539 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of chromosome organization |
| GO:0044784 | 0.0105478288276 | 1.0 | INCENP BIRC5 CDCA8 | metaphase/anaphase transition of cell cycle |
| REAC:R-HSA-69278 | 0.0112530904983 | 1.0 | INCENP BIRC5 CDCA8 | Cell Cycle, Mitotic |
| GO:0051310 | 0.0116771431902 | 1.0 | INCENP BIRC5 CDCA8 | metaphase chromosome alignment |
| GO:0051303 | 0.0128843147861 | 1.0 | INCENP BIRC5 CDCA8 | establishment of chromosome localization |
| GO:0033045 | 0.0133044554856 | 1.0 | INCENP BIRC5 CDCA8 | regulation of sister chromatid segregation |
| GO:0007088 | 0.0133044554856 | 1.0 | INCENP BIRC5 CDCA8 | regulation of mitotic nuclear division |
| GO:0050000 | 0.0150763323228 | 1.0 | INCENP BIRC5 CDCA8 | chromosome localization |
| GO:0061640 | 0.0165038110528 | 1.0 | INCENP BIRC5 CDCA8 | cytoskeleton-dependent cytokinesis |
| GO:0051225 | 0.0165038110528 | 1.0 | INCENP BIRC5 CDCA8 | spindle assembly |
| GO:0051783 | 0.0165038110528 | 1.0 | INCENP BIRC5 CDCA8 | regulation of nuclear division |
| REAC:R-HSA-194315 | 0.0193529117228 | 1.0 | INCENP BIRC5 CDCA8 | Signaling by Rho GTPases |
| GO:0051302 | 0.0201788647033 | 1.0 | INCENP BIRC5 CDCA8 | regulation of cell division |
| REAC:R-HSA-9716542 | 0.02067413488 | 1.0 | INCENP BIRC5 CDCA8 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | INCENP BIRC5 CDCA8 | Cell Cycle |
| GO:0007052 | 0.0225051619375 | 1.0 | INCENP BIRC5 CDCA8 | mitotic spindle organization |
| CORUM:2580 | 0.0249718442456 | 0.333333333333 | BIRC5 | Survivin homodimer complex |
| GO:0051983 | 0.0263194935275 | 1.0 | INCENP BIRC5 CDCA8 | regulation of chromosome segregation |
| GO:0005875 | 0.0290879429506 | 1.0 | INCENP BIRC5 CDCA8 | microtubule associated complex |
| GO:0007093 | 0.0298091316188 | 1.0 | INCENP BIRC5 CDCA8 | mitotic cell cycle checkpoint signaling |
| HPA:0030432 | 0.0366451526634 | 0.666666666667 | INCENP CDCA8 | appendix; germinal center cells[>=Medium] |
| HPA:0031293 | 0.0370192963486 | 0.666666666667 | INCENP CDCA8 | appendix; endocrine cells[High] |
| GO:1902850 | 0.043021407985 | 1.0 | INCENP BIRC5 CDCA8 | microtubule cytoskeleton organization involved in mitosis |
| HPA:0131293 | 0.0448972088574 | 0.666666666667 | INCENP CDCA8 | colon; endocrine cells[High] |
| GO:1901991 | 0.0468435252984 | 1.0 | INCENP BIRC5 CDCA8 | negative regulation of mitotic cell cycle phase transition |
| CORUM:1117 | 0.0499402709677 | 0.333333333333 | BIRC5 | CRM1-Survivin mitotic complex |
| CORUM:2581 | 0.0499402709677 | 0.333333333333 | BIRC5 | RasGAP-AURKA-survivin complex |
| CORUM:6756 | 0.0499402709677 | 0.333333333333 | BIRC5 | RasGAP-AURKB-survivin complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| BIRC5 | CDCA8 | 0.999 | 0.59 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| CDCA8 | INCENP | 0.998 | 0.606 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () |
| BIRC5 | INCENP | 0.994 | 0.758 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes