hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04355.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| E2F5 | Transcription factor E2F5 (E2F-5) | 5 | UniProt NCBI |
| TFDP2 | Transcription factor Dp-2 (E2F dimerization partner 2) | 5 | UniProt NCBI |
| E2F1 | Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1) | 5 | UniProt NCBI |
| E2F2 | Transcription factor E2F2 (E2F-2) | 5 | UniProt NCBI |
| MCIDAS | Multicilin (Multiciliate differentiation and DNA synthesis-associated cell cycle protein) (McIdas protein) (Protein Idas) | 5 | UniProt NCBI |
| E2F3 | Transcription factor E2F3 (E2F-3) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-69236 | 2.71631032929e-10 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | G1 Phase |
| REAC:R-HSA-69231 | 2.71631032929e-10 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Cyclin D associated events in G1 |
| REAC:R-HSA-9661069 | 3.44861810508e-09 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
| REAC:R-HSA-9659787 | 3.44861810508e-09 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
| WP:WP179 | 1.23535088637e-08 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Cell cycle |
| KEGG:04110 | 3.3935086085e-08 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Cell cycle |
| REAC:R-HSA-2559585 | 5.91891333952e-08 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Oncogene Induced Senescence |
| REAC:R-HSA-9687139 | 7.57200209391e-08 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| REAC:R-HSA-9675126 | 9.54895294338e-08 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Diseases of mitotic cell cycle |
| REAC:R-HSA-453279 | 1.05210790032e-07 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Mitotic G1 phase and G1/S transition |
| WP:WP45 | 3.57433698722e-07 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | G1 to S cell cycle control |
| WP:WP2446 | 1.1917303038e-06 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Retinoblastoma gene in cancer |
| REAC:R-HSA-1362300 | 3.20984225624e-06 | 0.5 | TFDP2 E2F5 E2F1 | Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 |
| REAC:R-HSA-1362277 | 5.75389190359e-06 | 0.5 | TFDP2 E2F5 E2F1 | Transcription of E2F targets under negative control by DREAM complex |
| KEGG:04218 | 6.1704720267e-06 | 0.666666666667 | E2F2 E2F3 E2F5 E2F1 | Cellular senescence |
| REAC:R-HSA-2559580 | 7.40415947683e-06 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Oxidative Stress Induced Senescence |
| KEGG:05219 | 1.41369735506e-05 | 0.5 | E2F3 E2F1 E2F2 | Bladder cancer |
| REAC:R-HSA-1538133 | 1.83108883385e-05 | 0.5 | TFDP2 E2F5 E2F1 | G0 and Early G1 |
| REAC:R-HSA-69205 | 2.05965741212e-05 | 0.5 | TFDP2 E2F5 E2F1 | G1/S-Specific Transcription |
| REAC:R-HSA-2559583 | 5.37610665202e-05 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Cellular Senescence |
| REAC:R-HSA-69278 | 6.34457226533e-05 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Cell Cycle, Mitotic |
| KEGG:05218 | 7.45825753524e-05 | 0.5 | E2F3 E2F1 E2F2 | Melanoma |
| WP:WP4685 | 9.35565731171e-05 | 0.5 | E2F3 E2F1 E2F2 | Melanoma |
| KEGG:05223 | 9.87392619558e-05 | 0.5 | E2F3 E2F1 E2F2 | Non-small cell lung cancer |
| KEGG:05214 | 9.87392619558e-05 | 0.5 | E2F3 E2F1 E2F2 | Glioma |
| KEGG:05212 | 0.000117431011352 | 0.5 | E2F3 E2F1 E2F2 | Pancreatic cancer |
| KEGG:05220 | 0.0001275988674 | 0.5 | E2F3 E2F1 E2F2 | Chronic myeloid leukemia |
| WP:WP4255 | 0.000130829517254 | 0.5 | E2F3 E2F1 E2F2 | Non small cell lung cancer |
| GO:0090575 | 0.000153415434737 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | RNA polymerase II transcription regulator complex |
| KEGG:01522 | 0.000174105219358 | 0.5 | E2F3 E2F1 E2F2 | Endocrine resistance |
| REAC:R-HSA-1640170 | 0.000178011057657 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | Cell Cycle |
| KEGG:05222 | 0.000201071778007 | 0.5 | E2F3 E2F1 E2F2 | Small cell lung cancer |
| KEGG:05215 | 0.000230675312915 | 0.5 | E2F3 E2F1 E2F2 | Prostate cancer |
| WP:WP4263 | 0.000232507244744 | 0.5 | E2F3 E2F1 E2F2 | Pancreatic adenocarcinoma pathway |
| REAC:R-HSA-68911 | 0.00025805759528 | 0.333333333333 | E2F1 E2F3 | G2 Phase |
| REAC:R-HSA-111448 | 0.00025805759528 | 0.333333333333 | TFDP2 E2F1 | Activation of NOXA and translocation to mitochondria |
| WP:WP4658 | 0.0003090931252 | 0.5 | E2F3 E2F1 E2F2 | Small cell lung cancer |
| GO:0001216 | 0.000399946966982 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | DNA-binding transcription activator activity |
| REAC:R-HSA-1912408 | 0.000491292751059 | 0.5 | TFDP2 E2F1 E2F3 | Pre-NOTCH Transcription and Translation |
| REAC:R-HSA-69202 | 0.000618329565809 | 0.5 | TFDP2 E2F5 E2F1 | Cyclin E associated events during G1/S transition |
| KEGG:04934 | 0.000620541886073 | 0.5 | E2F3 E2F1 E2F2 | Cushing syndrome |
| KEGG:05224 | 0.000650854752753 | 0.5 | E2F3 E2F1 E2F2 | Breast cancer |
| REAC:R-HSA-69656 | 0.000665071217307 | 0.5 | TFDP2 E2F5 E2F1 | Cyclin A:Cdk2-associated events at S phase entry |
| KEGG:05160 | 0.000714389632372 | 0.5 | E2F3 E2F1 E2F2 | Hepatitis C |
| KEGG:05226 | 0.000714389632372 | 0.5 | E2F3 E2F1 E2F2 | Gastric cancer |
| REAC:R-HSA-1912422 | 0.00087545051226 | 0.5 | TFDP2 E2F1 E2F3 | Pre-NOTCH Expression and Processing |
| REAC:R-HSA-139915 | 0.000928329318648 | 0.333333333333 | TFDP2 E2F1 | Activation of PUMA and translocation to mitochondria |
| KEGG:05161 | 0.00103019356944 | 0.5 | E2F3 E2F1 E2F2 | Hepatitis B |
| KEGG:05206 | 0.00103019356944 | 0.5 | E2F3 E2F1 E2F2 | MicroRNAs in cancer |
| WP:WP4262 | 0.00103618541451 | 0.5 | E2F3 E2F1 E2F2 | Breast cancer pathway |
| KEGG:05225 | 0.00127702731713 | 0.5 | E2F3 E2F1 E2F2 | Hepatocellular carcinoma |
| KEGG:05167 | 0.00150582306317 | 0.5 | E2F3 E2F1 E2F2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.00185087448797 | 0.5 | E2F3 E2F1 E2F2 | Epstein-Barr virus infection |
| REAC:R-HSA-113501 | 0.00200991204249 | 0.333333333333 | TFDP2 E2F1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| KEGG:05163 | 0.00224445303032 | 0.5 | E2F3 E2F1 E2F2 | Human cytomegalovirus infection |
| KEGG:05166 | 0.00246039647578 | 0.5 | E2F3 E2F1 E2F2 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-69206 | 0.00247941542207 | 0.5 | TFDP2 E2F5 E2F1 | G1/S Transition |
| GO:0005667 | 0.0025579351051 | 0.833333333333 | E2F3 TFDP2 E2F2 E2F5 E2F1 | transcription regulator complex |
| REAC:R-HSA-69242 | 0.00453532495717 | 0.5 | TFDP2 E2F5 E2F1 | S Phase |
| REAC:R-HSA-113510 | 0.00594265866298 | 0.333333333333 | TFDP2 E2F1 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-157118 | 0.00955209385839 | 0.5 | TFDP2 E2F1 E2F3 | Signaling by NOTCH |
| REAC:R-HSA-114452 | 0.0111743831709 | 0.333333333333 | TFDP2 E2F1 | Activation of BH3-only proteins |
| WP:WP5180 | 0.0142825477425 | 0.333333333333 | TFDP2 E2F5 | DYRK1A involvement regarding cell proliferation in brain development |
| REAC:R-HSA-8953750 | 0.0144005758041 | 0.333333333333 | TFDP2 E2F1 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-2262752 | 0.0151203724991 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Cellular responses to stress |
| REAC:R-HSA-8953897 | 0.015703244896 | 0.666666666667 | TFDP2 E2F3 E2F1 E2F2 | Cellular responses to stimuli |
| REAC:R-HSA-2173796 | 0.0161658624528 | 0.333333333333 | TFDP2 E2F5 | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| REAC:R-HSA-6791312 | 0.0253617614497 | 0.333333333333 | TFDP2 E2F1 | TP53 Regulates Transcription of Cell Cycle Genes |
| KEGG:05200 | 0.0272817161758 | 0.5 | E2F3 E2F1 E2F2 | Pathways in cancer |
| REAC:R-HSA-2173793 | 0.0313533174732 | 0.333333333333 | TFDP2 E2F5 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer |
| REAC:R-HSA-109606 | 0.0339259639772 | 0.333333333333 | TFDP2 E2F1 | Intrinsic Pathway for Apoptosis |
| WP:WP2431 | 0.039710885216 | 0.333333333333 | E2F5 E2F1 | Spinal cord injury |
| GO:0035189 | 0.042122686785 | 0.333333333333 | E2F1 E2F2 | Rb-E2F complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| E2F5 | TFDP2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM | |
| TFDP2 | E2F2 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TFDP2 | E2F3 | 0.996 | 0.152 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| TFDP2 | E2F1 | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| MCIDAS | TFDP2 | 0.985 | bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| E2F2 | E2F3 | 0.961 | bioplex_WMM bioplex3_WMM WMM_only | |
| E2F5 | E2F2 | 0.959 | bioplex_WMM bioplex3_WMM WMM_only | |
| E2F5 | E2F3 | 0.924 | bioplex_WMM bioplex3_WMM WMM_only | |
| MCIDAS | E2F2 | 0.902 | bioplex3_WMM WMM_only | |
| MCIDAS | E2F3 | 0.902 | bioplex3_WMM WMM_only | |
| MCIDAS | E2F5 | 0.892 | bioplex_WMM bioplex3_WMM WMM_only boldt_WMM | |
| E2F1 | E2F3 | 0.582 | bioplex_WMM bioplex3_WMM WMM_only | |
| E2F1 | E2F2 | 0.568 | bioplex_WMM bioplex3_WMM WMM_only | |
| E2F5 | E2F1 | 0.541 | bioplex_WMM bioplex3_WMM WMM_only | |
| MCIDAS | E2F1 | 0.214 | bioplex3_WMM WMM_only |
Related Complexes