hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04356.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GTF2A1 | Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)] | 5 | UniProt NCBI |
| TAF7L | Transcription initiation factor TFIID subunit 7-like (Cancer/testis antigen 40) (CT40) (RNA polymerase II TBP-associated factor subunit Q) (TATA box-binding protein-associated factor 50 kDa) (Transcription initiation factor TFIID 50 kDa subunit) | 5 | UniProt NCBI |
| GTF2A2 | Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma) | 5 | UniProt NCBI |
| TBPL1 | TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein) | 5 | UniProt NCBI |
| TAF8 | Transcription initiation factor TFIID subunit 8 (Protein taube nuss) (TBP-associated factor 43 kDa) (TBP-associated factor 8) (Transcription initiation factor TFIID 43 kDa subunit) (TAFII-43) (TAFII43) (hTAFII43) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03022 | 6.5513325354e-12 | 1.0 | TAF7L TBPL1 TAF8 GTF2A1 GTF2A2 | Basal transcription factors |
| GO:0016251 | 3.92498696838e-09 | 1.0 | TAF7L TBPL1 TAF8 GTF2A1 GTF2A2 | RNA polymerase II general transcription initiation factor activity |
| GO:0140223 | 1.54182545094e-08 | 1.0 | TAF7L TBPL1 TAF8 GTF2A1 GTF2A2 | general transcription initiation factor activity |
| GO:0005669 | 4.13351489328e-06 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | transcription factor TFIID complex |
| GO:0006352 | 4.33118879937e-06 | 1.0 | TAF7L TBPL1 TAF8 GTF2A1 GTF2A2 | DNA-templated transcription initiation |
| CORUM:490 | 1.36501667663e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
| CORUM:489 | 1.36501667663e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA complex |
| GO:0051123 | 3.5523826943e-05 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | RNA polymerase II preinitiation complex assembly |
| CORUM:1221 | 4.09448956317e-05 | 0.4 | GTF2A1 GTF2A2 | TFIIA-TRF2 complex |
| GO:0070897 | 4.14930734417e-05 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | transcription preinitiation complex assembly |
| REAC:R-HSA-167161 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | HIV Transcription Initiation |
| REAC:R-HSA-76042 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation And Promoter Clearance |
| REAC:R-HSA-75953 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II Transcription Initiation |
| REAC:R-HSA-73776 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II Promoter Escape |
| REAC:R-HSA-167162 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II HIV Promoter Escape |
| REAC:R-HSA-73779 | 4.40931593476e-05 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| GO:0016591 | 0.00010676760833 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | RNA polymerase II, holoenzyme |
| REAC:R-HSA-167172 | 0.00015535926553 | 0.6 | TAF7L GTF2A1 GTF2A2 | Transcription of the HIV genome |
| REAC:R-HSA-6807505 | 0.00018480745401 | 0.6 | TAF8 GTF2A1 GTF2A2 | RNA polymerase II transcribes snRNA genes |
| REAC:R-HSA-674695 | 0.000244866764891 | 0.6 | TAF7L GTF2A1 GTF2A2 | RNA Polymerase II Pre-transcription Events |
| GO:0055029 | 0.000365836607157 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.000382257669512 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.00043484599868 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | RNA polymerase complex |
| GO:0006367 | 0.000936247584533 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | transcription initiation at RNA polymerase II promoter |
| KEGG:05203 | 0.000966347133386 | 0.6 | TBPL1 GTF2A1 GTF2A2 | Viral carcinogenesis |
| REAC:R-HSA-162599 | 0.00110198471879 | 0.6 | TAF7L GTF2A1 GTF2A2 | Late Phase of HIV Life Cycle |
| CORUM:492 | 0.00143071895731 | 0.4 | GTF2A1 GTF2A2 | DA complex |
| REAC:R-HSA-162587 | 0.00143724099843 | 0.6 | TAF7L GTF2A1 GTF2A2 | HIV Life Cycle |
| CORUM:493 | 0.00163488349218 | 0.4 | GTF2A1 GTF2A2 | DAB complex |
| GO:0065004 | 0.00378855826806 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | protein-DNA complex assembly |
| REAC:R-HSA-162906 | 0.00541502775671 | 0.6 | TAF7L GTF2A1 GTF2A2 | HIV Infection |
| GO:0090575 | 0.00929711903114 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | RNA polymerase II transcription regulator complex |
| GO:0005672 | 0.0140440992017 | 0.4 | GTF2A1 GTF2A2 | transcription factor TFIIA complex |
| GO:0060261 | 0.0237169649094 | 0.6 | TAF8 GTF2A1 GTF2A2 | positive regulation of transcription initiation by RNA polymerase II |
| REAC:R-HSA-73857 | 0.0284318585439 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | RNA Polymerase II Transcription |
| GO:0061695 | 0.0306592465565 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | transferase complex, transferring phosphorus-containing groups |
| GO:2000144 | 0.0327001087246 | 0.6 | TAF8 GTF2A1 GTF2A2 | positive regulation of DNA-templated transcription initiation |
| GO:0060260 | 0.0343879535233 | 0.6 | TAF8 GTF2A1 GTF2A2 | regulation of transcription initiation by RNA polymerase II |
| GO:2000142 | 0.0457443058639 | 0.6 | TAF8 GTF2A1 GTF2A2 | regulation of DNA-templated transcription initiation |
| REAC:R-HSA-74160 | 0.046583533294 | 0.8 | TAF7L TAF8 GTF2A1 GTF2A2 | Gene expression (Transcription) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GTF2A1 | GTF2A2 | 1.0 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| GTF2A1 | TBPL1 | 1.0 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
| TAF7L | TAF8 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TBPL1 | GTF2A2 | 0.997 | 0.09 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM WMM_only |
| TAF8 | GTF2A1 | 0.994 | 0.224 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| TAF7L | GTF2A1 | 0.986 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TAF8 | TBPL1 | 0.016 | 0.252 | youn_WMM WMM_only |
| TAF8 | GTF2A2 | 0.015 | 0.174 | youn_WMM WMM_only |
Related Complexes