hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04360.1
Complex Portal: CPX-12221
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C1R | Complement C1r subcomponent (EC 3.4.21.41) (Complement component 1 subcomponent r) [Cleaved into: Complement C1r subcomponent heavy chain; Complement C1r subcomponent light chain] | 5 | UniProt NCBI |
| C1S | Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0034517 | 0.0495817777049 | 1.0 | C1S | Pretibial hyperpigmentation |
| HP:0034518 | 0.0495817777049 | 1.0 | C1S | Gingival fragility |
| REAC:R-HSA-173623 | 0.0499436884912 | 1.0 | C1S | Classical antibody-mediated complement activation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| C1R | C1S | 0.994 | 0.384 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| C1R | huMAP3_00148.1 huMAP3_04360.1 huMAP3_05236.1 huMAP3_10944.1 |
| C1S | huMAP3_00148.1 huMAP3_04360.1 huMAP3_10944.1 huMAP3_11660.1 |