hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04382.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATG16L2 | Protein Atg16l2 (APG16-like 2) (Autophagy-related protein 16-2) (WD repeat-containing protein 80) | 4 | UniProt NCBI |
| ATG5 | Autophagy protein 5 (APG5-like) (Apoptosis-specific protein) | 5 | UniProt NCBI |
| ATG12 | Ubiquitin-like protein ATG12 (Autophagy-related protein 12) (APG12-like) | 5 | UniProt NCBI |
| TECPR1 | Tectonin beta-propeller repeat-containing protein 1 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4863 | 2.84994785564e-07 | 0.75 | ATG16L2 ATG5 ATG12 | Host pathogen interaction of human coronaviruses autophagy |
| GO:0034274 | 7.68841921772e-06 | 0.75 | ATG16L2 ATG5 ATG12 | Atg12-Atg5-Atg16 complex |
| GO:0005776 | 3.3758447769e-05 | 1.0 | ATG16L2 TECPR1 ATG5 ATG12 | autophagosome |
| GO:0034045 | 0.000174830724535 | 0.75 | ATG16L2 ATG5 ATG12 | phagophore assembly site membrane |
| KEGG:04140 | 0.000211376960202 | 0.75 | ATG16L2 ATG5 ATG12 | Autophagy - animal |
| GO:1901096 | 0.000215165225046 | 0.75 | ATG12 ATG5 TECPR1 | regulation of autophagosome maturation |
| REAC:R-HSA-8934903 | 0.000286914834749 | 0.5 | ATG12 ATG5 | Receptor Mediated Mitophagy |
| WP:WP2509 | 0.000588856887782 | 0.5 | ATG12 ATG5 | Nanoparticle triggered autophagic cell death |
| KEGG:05131 | 0.000652828786911 | 0.75 | ATG12 ATG5 TECPR1 | Shigellosis |
| WP:WP4923 | 0.00096305612306 | 0.5 | ATG12 ATG5 | Autophagy |
| KEGG:04136 | 0.00108828934266 | 0.5 | ATG12 ATG5 | Autophagy - other |
| GO:0000407 | 0.00190418300832 | 0.75 | ATG16L2 ATG5 ATG12 | phagophore assembly site |
| WP:WP4577 | 0.00198508114189 | 0.5 | ATG12 ATG5 | Neurodegeneration with brain iron accumulation NBIA subtypes pathway |
| REAC:R-HSA-5205685 | 0.00214930898727 | 0.5 | ATG12 ATG5 | PINK1-PRKN Mediated Mitophagy |
| REAC:R-HSA-5205647 | 0.00332479301982 | 0.5 | ATG12 ATG5 | Mitophagy |
| WP:WP3865 | 0.00363720277712 | 0.5 | ATG12 ATG5 | Novel intracellular components of RIG I like receptor pathway |
| KEGG:04622 | 0.00518715200321 | 0.5 | ATG12 ATG5 | RIG-I-like receptor signaling pathway |
| WP:WP4655 | 0.00528146385782 | 0.5 | ATG12 ATG5 | Cytosolic DNA sensing pathway |
| REAC:R-HSA-936440 | 0.00539805716719 | 0.5 | ATG12 ATG5 | Negative regulators of DDX58/IFIH1 signaling |
| WP:WP5205 | 0.00578263137464 | 0.5 | ATG12 ATG5 | Clock controlled autophagy in bone metabolism |
| GO:0016236 | 0.00595686338265 | 1.0 | ATG16L2 TECPR1 ATG5 ATG12 | macroautophagy |
| GO:0097352 | 0.00706693750215 | 0.75 | ATG12 ATG5 TECPR1 | autophagosome maturation |
| GO:1904973 | 0.00842684400117 | 0.5 | ATG12 ATG5 | positive regulation of viral translation |
| GO:1904971 | 0.00842684400117 | 0.5 | ATG12 ATG5 | regulation of viral translation |
| KEGG:04621 | 0.02620193588 | 0.5 | ATG12 ATG5 | NOD-like receptor signaling pathway |
| REAC:R-HSA-9663891 | 0.0282617295192 | 0.5 | ATG12 ATG5 | Selective autophagy |
| REAC:R-HSA-168928 | 0.0282617295192 | 0.5 | ATG12 ATG5 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| GO:0061919 | 0.0431855442038 | 1.0 | ATG16L2 TECPR1 ATG5 ATG12 | process utilizing autophagic mechanism |
| GO:0006914 | 0.0431855442038 | 1.0 | ATG16L2 TECPR1 ATG5 ATG12 | autophagy |
| GO:0043244 | 0.0434703685672 | 0.75 | ATG12 ATG5 TECPR1 | regulation of protein-containing complex disassembly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| ATG5 | TECPR1 | 0.999 | 0.09 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ATG5 | ATG12 | 0.999 | 0.442 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| ATG16L2 | ATG5 | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| ATG16L2 | TECPR1 | 0.946 | bioplex3_WMM WMM_only | |
| ATG12 | TECPR1 | 0.779 | 0.134 | bioplex3_WMM WMM_only |
| ATG16L2 | ATG12 | 0.779 | bioplex3_WMM WMM_only |
Related Complexes