hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04392.1
Complex Portal: CPX-13715
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TMED4 | Transmembrane emp24 domain-containing protein 4 (Endoplasmic reticulum stress-response protein 25) (ERS25) (GMP25iso) (Putative NF-kappa-B-activating protein 156) (p24 family protein alpha-3) (p24alpha3) | 5 | UniProt NCBI |
| TMED3 | Transmembrane emp24 domain-containing protein 3 (Membrane protein p24B) (p24 family protein gamma-4) (p24gamma4) (p26) | 5 | UniProt NCBI |
| GOLGB1 | Golgin subfamily B member 1 (372 kDa Golgi complex-associated protein) (GCP372) (Giantin) (Macrogolgin) | 5 | UniProt NCBI |
| TMED2 | Transmembrane emp24 domain-containing protein 2 (Membrane protein p24A) (p24) (p24 family protein beta-1) (p24beta1) | 5 | UniProt NCBI |
| FGF3 | Fibroblast growth factor 3 (FGF-3) (Heparin-binding growth factor 3) (HBGF-3) (Proto-oncogene Int-2) | 5 | UniProt NCBI |
| TMED9 | Transmembrane emp24 domain-containing protein 9 (GMP25) (Glycoprotein 25L2) (p24 family protein alpha-2) (p24alpha2) (p25) | 5 | UniProt NCBI |
| CTXN1 | Cortexin-1 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005793 | 2.64367621138e-06 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | endoplasmic reticulum-Golgi intermediate compartment |
| REAC:R-HSA-6807878 | 4.77193991841e-06 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | COPI-mediated anterograde transport |
| GO:0007030 | 1.02286966494e-05 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | Golgi organization |
| REAC:R-HSA-199977 | 2.38677750493e-05 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | ER to Golgi Anterograde Transport |
| REAC:R-HSA-948021 | 5.01545306007e-05 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-446203 | 0.000368135889543 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | Asparagine N-linked glycosylation |
| GO:0030134 | 0.000426352174493 | 0.666666666667 | TMED4 TMED9 TMED2 TMED3 | COPII-coated ER to Golgi transport vesicle |
| REAC:R-HSA-6811434 | 0.00090449234483 | 0.5 | TMED3 TMED9 TMED2 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-8856688 | 0.0022572388362 | 0.5 | TMED3 TMED9 TMED2 | Golgi-to-ER retrograde transport |
| HPA:0170053 | 0.00228336490701 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | endometrium 2; glandular cells[High] |
| GO:0006888 | 0.0029910931425 | 0.666666666667 | TMED4 TMED9 TMED2 TMED3 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| HPA:0160053 | 0.00369661132563 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | endometrium 1; glandular cells[High] |
| HPA:0420053 | 0.00372359431207 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | salivary gland; glandular cells[High] |
| REAC:R-HSA-199991 | 0.00605429919172 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | Membrane Trafficking |
| GO:0010256 | 0.00683949129129 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | endomembrane system organization |
| REAC:R-HSA-5653656 | 0.00750133147239 | 0.666666666667 | TMED3 TMED9 GOLGB1 TMED2 | Vesicle-mediated transport |
| REAC:R-HSA-6811442 | 0.008095711192 | 0.5 | TMED3 TMED9 TMED2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| HPA:0180053 | 0.01045837038 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | epididymis; glandular cells[High] |
| HPA:0350473 | 0.0137848177277 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | pancreas; exocrine glandular cells[High] |
| HPA:0610833 | 0.0169334987823 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | urinary bladder; urothelial cells[High] |
| GO:0033116 | 0.0289892662643 | 0.5 | TMED3 TMED9 TMED2 | endoplasmic reticulum-Golgi intermediate compartment membrane |
| GO:0030135 | 0.0386403705075 | 0.666666666667 | TMED4 TMED9 TMED2 TMED3 | coated vesicle |
| HPA:0550053 | 0.0401973652514 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | stomach 2; glandular cells[High] |
| HPA:0540053 | 0.0412728490261 | 0.833333333333 | TMED4 TMED9 GOLGB1 TMED2 TMED3 | stomach 1; glandular cells[High] |
| WP:WP5380 | 0.0451642815361 | 0.333333333333 | TMED2 TMED9 | 5q35 copy number variation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TMED2 | TMED9 | 1.0 | 0.92 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| TMED4 | TMED2 | 1.0 | 0.922 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt hein () bioplex3_HCT116 fraction boldt_WMM treiber_WMM | |
| TMED3 | TMED2 | 1.0 | 0.356 |
mutually_exclusive (P49755)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 fraction |
| TMED3 | TMED9 | 0.999 | 0.212 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| TMED4 | TMED9 | 0.997 | 0.734 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM treiber_WMM WMM_only | |
| TMED4 | TMED3 | 0.997 | 0.236 |
mutually_exclusive (Q9Y3B3)
structurally_consistent (dimer) |
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CTXN1 | TMED2 | 0.994 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | ||
| GOLGB1 | TMED2 | 0.994 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| GOLGB1 | TMED9 | 0.992 | 0.2 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| FGF3 | TMED2 | 0.977 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| FGF3 | TMED9 | 0.949 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| CTXN1 | TMED9 | 0.949 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| FGF3 | TMED4 | 0.93 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| TMED4 | GOLGB1 | 0.89 | 0.178 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CTXN1 | TMED3 | 0.857 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TMED3 | GOLGB1 | 0.844 | 0.138 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CTXN1 | TMED4 | 0.759 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| CTXN1 | GOLGB1 | 0.306 | bioplex3_HEK293 bioplex3_WMM WMM_only |
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