hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04401.1
Complex Portal: CPX-19455
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIF5B | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | 5 | UniProt NCBI |
| KIF5C | Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1) | 5 | UniProt NCBI |
| KLC4 | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | 5 | UniProt NCBI |
| SYNE4 | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | 5 | UniProt NCBI |
| KLC3 | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | 5 | UniProt NCBI |
| KIF5A | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | 5 | UniProt NCBI |
| KLC2 | Kinesin light chain 2 (KLC 2) | 5 | UniProt NCBI |
| KLC1 | Kinesin light chain 1 (KLC 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5625970 | 2.03438274486e-16 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | RHO GTPases activate KTN1 |
| KEGG:04814 | 7.08368733142e-12 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Motor proteins |
| REAC:R-HSA-983189 | 1.13154713205e-11 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Kinesins |
| KEGG:05132 | 7.07473938513e-11 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Salmonella infection |
| KEGG:05012 | 1.08663781589e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Parkinson disease |
| KEGG:05020 | 1.33394808764e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Prion disease |
| WP:WP5124 | 1.62133317638e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Alzheimer 39 s disease |
| WP:WP2059 | 1.62133317638e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Alzheimer 39 s disease and miRNA effects |
| KEGG:05016 | 2.72086763556e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Huntington disease |
| REAC:R-HSA-6811434 | 3.32426359213e-10 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | COPI-dependent Golgi-to-ER retrograde traffic |
| KEGG:05014 | 9.59227433045e-10 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Amyotrophic lateral sclerosis |
| KEGG:05010 | 1.34702810824e-09 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Alzheimer disease |
| REAC:R-HSA-2132295 | 1.36013176525e-09 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | MHC class II antigen presentation |
| REAC:R-HSA-8856688 | 2.13958130543e-09 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Golgi-to-ER retrograde transport |
| KEGG:05022 | 5.38157012987e-09 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | Pathways of neurodegeneration - multiple diseases |
| REAC:R-HSA-983231 | 8.17326655106e-09 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-6811442 | 2.86020037528e-08 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0005871 | 2.18597902782e-07 | 0.625 | KLC2 KIF5B KIF5A KLC1 KIF5C | kinesin complex |
| GO:0007018 | 2.74807631192e-07 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | microtubule-based movement |
| REAC:R-HSA-195258 | 3.77931986678e-07 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | RHO GTPase Effectors |
| REAC:R-HSA-109582 | 1.17048169432e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Hemostasis |
| REAC:R-HSA-199991 | 1.97177804739e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Membrane Trafficking |
| GO:0098971 | 2.15253635486e-05 | 0.375 | KIF5B KIF5A KIF5C | anterograde dendritic transport of neurotransmitter receptor complex |
| REAC:R-HSA-5653656 | 2.7250868174e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Vesicle-mediated transport |
| REAC:R-HSA-264876 | 3.03234516525e-05 | 0.375 | KIF5B KIF5A KIF5C | Insulin processing |
| REAC:R-HSA-194315 | 3.46737483099e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 3.95146816329e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| GO:0019894 | 4.35075554541e-05 | 0.5 | KLC3 KLC4 KLC1 KLC2 | kinesin binding |
| REAC:R-HSA-1280218 | 4.73913973479e-05 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Adaptive Immune System |
| GO:0005875 | 0.000106768235941 | 0.625 | KLC2 KIF5B KIF5A KLC1 KIF5C | microtubule associated complex |
| GO:0098935 | 0.00010757157937 | 0.375 | KIF5B KIF5A KIF5C | dendritic transport |
| GO:0098937 | 0.00010757157937 | 0.375 | KIF5B KIF5A KIF5C | anterograde dendritic transport |
| GO:0007017 | 0.000202850678908 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | microtubule-based process |
| GO:0008092 | 0.000237865963031 | 0.875 | KLC2 KIF5B KIF5A KLC3 KIF5C KLC4 KLC1 | cytoskeletal protein binding |
| KEGG:05223 | 0.000262665274355 | 0.375 | KIF5B KIF5A KIF5C | Non-small cell lung cancer |
| GO:0099641 | 0.000301045822538 | 0.375 | KIF5B KIF5A KIF5C | anterograde axonal protein transport |
| GO:0099640 | 0.000301045822538 | 0.375 | KIF5B KIF5A KIF5C | axo-dendritic protein transport |
| GO:1905383 | 0.000644767051209 | 0.375 | KIF5B KIF5A KIF5C | protein localization to presynapse |
| GO:0099118 | 0.000644767051209 | 0.375 | KIF5B KIF5A KIF5C | microtubule-based protein transport |
| GO:0098840 | 0.000644767051209 | 0.375 | KIF5B KIF5A KIF5C | protein transport along microtubule |
| REAC:R-HSA-2980736 | 0.00103131007969 | 0.375 | KIF5B KIF5A KIF5C | Peptide hormone metabolism |
| KEGG:04728 | 0.00108873980413 | 0.375 | KIF5B KIF5A KIF5C | Dopaminergic synapse |
| GO:0008574 | 0.00195378579303 | 0.375 | KIF5B KIF5A KIF5C | plus-end-directed microtubule motor activity |
| GO:0003774 | 0.00441407178313 | 0.5 | KIF5B KIF5A KLC1 KIF5C | cytoskeletal motor activity |
| KEGG:04144 | 0.0101901500628 | 0.375 | KIF5B KIF5A KIF5C | Endocytosis |
| REAC:R-HSA-168256 | 0.0113619114179 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Immune System |
| WP:WP4535 | 0.016652650636 | 0.25 | KIF5B SYNE4 | Envelope proteins and their potential roles in EDMD physiopathology |
| GO:0097120 | 0.0265002084656 | 0.375 | KIF5B KIF5A KIF5C | receptor localization to synapse |
| GO:0048489 | 0.0265002084656 | 0.375 | KIF5B KIF5A KIF5C | synaptic vesicle transport |
| GO:0035418 | 0.0319547930493 | 0.375 | KIF5B KIF5A KIF5C | protein localization to synapse |
| REAC:R-HSA-162582 | 0.0324681032361 | 0.75 | KLC2 KIF5B KIF5A KLC3 KLC4 KLC1 | Signal Transduction |
| GO:0097479 | 0.0414601269437 | 0.375 | KIF5B KIF5A KIF5C | synaptic vesicle localization |
| CORUM:5401 | 0.0499436884912 | 0.125 | KIF5B | PLEKHM2-KIF5B complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KLC4 | KLC3 | 1.0 | 0.206 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| KIF5A | KLC1 | 1.0 | 0.136 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KLC4 | KLC1 | 1.0 | 0.274 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| KIF5B | KLC1 | 1.0 | 0.584 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KIF5C | KLC1 | 1.0 | 0.102 | bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| KLC3 | KIF5A | 1.0 | 0.094 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| KIF5B | KLC3 | 1.0 | 0.18 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM | |
| KLC3 | KLC2 | 1.0 | 0.138 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 boldt_WMM |
| KIF5B | KLC2 | 1.0 | 0.478 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| KLC2 | KLC1 | 1.0 | 0.682 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM | |
| KIF5C | KLC3 | 0.999 | 0.154 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM WMM_only |
| KIF5C | SYNE4 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLC4 | KLC2 | 0.999 | 0.154 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM hein () gupta_WMM boldt_WMM treiber_WMM | |
| KLC3 | KLC1 | 0.999 | 0.1 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 boldt_WMM | |
| SYNE4 | KLC1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYNE4 | KLC3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF5C | KLC4 | 0.999 | 0.126 | bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM | |
| KIF5B | KLC4 | 0.998 | 0.22 | hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () gupta_WMM fraction boldt_WMM treiber_WMM | |
| KLC4 | SYNE4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF5C | KLC2 | 0.998 | 0.154 |
mutually_exclusive (Q6P597)
|
bioplex_WMM Guru bioplex3_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5B | SYNE4 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| SYNE4 | KLC2 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KLC4 | KIF5A | 0.997 | 0.322 | bioplex_WMM Guru bioplex3_WMM boldt gupta_WMM fraction boldt_WMM | |
| SYNE4 | KIF5A | 0.996 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| KIF5C | KIF5A | 0.99 | 0.186 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KIF5B | KIF5A | 0.985 | 0.2028 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KIF5A | KLC2 | 0.983 | 0.14 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only | |
| KIF5B | KIF5C | 0.97 | 0.374 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
Related Complexes