hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04405.1
Complex Portal: CPX-17994
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SACM1L | Phosphatidylinositol-3-phosphatase SAC1 (EC 3.1.3.64) (Phosphatidylinositol-4-phosphate phosphatase) (Suppressor of actin mutations 1-like protein) | 5 | UniProt NCBI |
| COPB2 | Coatomer subunit beta' (Beta'-coat protein) (Beta'-COP) (p102) | 5 | UniProt NCBI |
| COPG2 | Coatomer subunit gamma-2 (Gamma-2-coat protein) (Gamma-2-COP) | 5 | UniProt NCBI |
| COPG1 | Coatomer subunit gamma-1 (Gamma-1-coat protein) (Gamma-1-COP) | 5 | UniProt NCBI |
| ARCN1 | Coatomer subunit delta (Archain) (Delta-coat protein) (Delta-COP) | 5 | UniProt NCBI |
| COPZ2 | Coatomer subunit zeta-2 (Zeta-2-coat protein) (Zeta-2 COP) | 4 | UniProt NCBI |
| COPZ1 | Coatomer subunit zeta-1 (Zeta-1-coat protein) (Zeta-1 COP) | 5 | UniProt NCBI |
| COPA | Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin] | 5 | UniProt NCBI |
| COPB1 | Coatomer subunit beta (Beta-coat protein) (Beta-COP) | 5 | UniProt NCBI |
| COPE | Coatomer subunit epsilon (Epsilon-coat protein) (Epsilon-COP) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030126 | 4.27378448124e-24 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | COPI vesicle coat |
| GO:0030663 | 1.45272848715e-22 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | COPI-coated vesicle membrane |
| GO:0030137 | 1.00351768677e-21 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | COPI-coated vesicle |
| GO:0030660 | 5.28643454881e-18 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Golgi-associated vesicle membrane |
| REAC:R-HSA-6811434 | 2.76369754519e-17 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-6807878 | 3.72473918817e-17 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | COPI-mediated anterograde transport |
| GO:0030120 | 5.36289128407e-17 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | vesicle coat |
| GO:0005798 | 3.37577999031e-16 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Golgi-associated vesicle |
| GO:0006891 | 4.57952781196e-16 | 0.8 | COPE COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | intra-Golgi vesicle-mediated transport |
| REAC:R-HSA-8856688 | 4.72172505872e-16 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-199977 | 1.52664517689e-15 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | ER to Golgi Anterograde Transport |
| GO:0030117 | 3.05188523886e-15 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | membrane coat |
| GO:0048475 | 3.05188523886e-15 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | coated membrane |
| REAC:R-HSA-948021 | 8.39108348069e-15 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Transport to the Golgi and subsequent modification |
| REAC:R-HSA-6811442 | 2.4194665305e-14 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0030662 | 4.07876668118e-13 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | coated vesicle membrane |
| REAC:R-HSA-446203 | 8.01227209794e-13 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Asparagine N-linked glycosylation |
| GO:0000139 | 1.16781725173e-11 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | Golgi membrane |
| GO:0030135 | 1.88282990225e-11 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | coated vesicle |
| GO:0030133 | 5.75641202418e-11 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | transport vesicle |
| GO:0048193 | 1.08033859244e-10 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Golgi vesicle transport |
| REAC:R-HSA-199991 | 4.80273848833e-10 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 7.84268702177e-10 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Vesicle-mediated transport |
| GO:0005789 | 3.11850675078e-09 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | endoplasmic reticulum membrane |
| GO:0098827 | 3.64592484152e-09 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | endoplasmic reticulum subcompartment |
| GO:0042175 | 3.96625551604e-09 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | nuclear outer membrane-endoplasmic reticulum membrane network |
| GO:0006888 | 1.09879726416e-08 | 0.7 | COPE COPB1 COPG1 COPA ARCN1 COPG2 COPB2 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| GO:0006890 | 1.22131360901e-08 | 0.6 | ARCN1 COPZ2 COPA COPZ1 COPG2 COPB2 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
| GO:0031984 | 5.79077579384e-08 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | organelle subcompartment |
| GO:0005794 | 3.6143972e-07 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | Golgi apparatus |
| REAC:R-HSA-597592 | 4.67336663847e-07 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Post-translational protein modification |
| GO:0030659 | 1.13864426091e-06 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | cytoplasmic vesicle membrane |
| GO:0012506 | 1.31323581259e-06 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | vesicle membrane |
| GO:0005783 | 2.77476326542e-06 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | endoplasmic reticulum |
| GO:0098588 | 4.36975560462e-06 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | bounding membrane of organelle |
| GO:0098796 | 7.26942127428e-06 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | membrane protein complex |
| REAC:R-HSA-392499 | 8.6312875687e-06 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | Metabolism of proteins |
| GO:0046907 | 2.99986682905e-05 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | intracellular transport |
| GO:0016192 | 3.45008274803e-05 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | vesicle-mediated transport |
| GO:0051649 | 0.000279066091397 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | establishment of localization in cell |
| GO:0031090 | 0.000959229479862 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | organelle membrane |
| GO:0031410 | 0.00137129474097 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | cytoplasmic vesicle |
| GO:0097708 | 0.00139355619292 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | intracellular vesicle |
| HPA:0180053 | 0.00273661010257 | 0.7 | COPE COPB1 COPG1 COPA ARCN1 COPG2 COPB2 | epididymis; glandular cells[High] |
| GO:0015031 | 0.00552416206626 | 0.7 | ARCN1 COPG1 COPZ2 COPA COPZ1 COPG2 COPB2 | protein transport |
| HPA:0430053 | 0.0118998753083 | 0.6 | COPB1 COPG1 COPA ARCN1 COPG2 COPB2 | seminal vesicle; glandular cells[High] |
| HPA:0550053 | 0.016995536439 | 0.7 | SACM1L COPE COPG1 COPA COPG2 ARCN1 COPB2 | stomach 2; glandular cells[High] |
| GO:0012505 | 0.018998349123 | 1.0 | SACM1L COPZ1 COPE COPG1 COPB1 COPG2 COPA COPZ2 ARCN1 COPB2 | endomembrane system |
| HPA:0351182 | 0.0226910832735 | 0.8 | SACM1L COPE COPG1 COPB1 COPA COPG2 ARCN1 COPB2 | pancreas; pancreatic endocrine cells[>=Medium] |
| HPA:0290402 | 0.0253640161741 | 0.8 | SACM1L COPE COPG1 COPB1 COPA COPG2 ARCN1 COPB2 | liver; hepatocytes[>=Medium] |
| GO:0051641 | 0.0345887146099 | 0.9 | COPE ARCN1 COPG1 COPZ2 COPB1 COPA COPZ1 COPG2 COPB2 | cellular localization |
| GO:0045184 | 0.0348460317846 | 0.7 | ARCN1 COPG1 COPZ2 COPA COPZ1 COPG2 COPB2 | establishment of protein localization |
| HPA:0220053 | 0.048380370567 | 0.7 | SACM1L COPG1 COPB1 COPA COPG2 ARCN1 COPB2 | gallbladder; glandular cells[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| COPB2 | COPE | 1.0 | 0.964 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| COPA | COPE | 1.0 | 0.924 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| COPB1 | COPE | 1.0 | 0.962 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| COPB2 | COPA | 1.0 | 0.964 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt youn_WMM hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPG1 | COPE | 1.0 | 0.91 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| COPB2 | COPG1 | 1.0 | 0.962 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| COPG1 | ARCN1 | 1.0 | 0.85 |
structurally_consistent (P53618)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| ARCN1 | COPB1 | 1.0 | 0.986 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPG1 | COPB1 | 1.0 | 0.99 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM boldt Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| ARCN1 | COPA | 1.0 | 0.816 | hein_WMM bioplex_WMM bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| COPB2 | ARCN1 | 1.0 | 0.972 | hein_WMM bioplex_WMM bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM | |
| COPA | COPB1 | 1.0 | 0.986 |
structurally_consistent (P35606)
structurally_consistent (dimer) |
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt hein () Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPG2 | COPE | 1.0 | 0.428 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM | |
| COPB2 | COPB1 | 1.0 | 0.974 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM Guru bioplex3_WMM boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| COPG1 | COPA | 1.0 | 0.952 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () Malo bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM | |
| COPG2 | COPG1 | 0.999 | 0.476 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 fraction boldt_WMM treiber_WMM |
| ARCN1 | COPE | 0.999 | 0.88 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM fraction boldt_WMM treiber_WMM |
| COPG2 | COPB1 | 0.999 | 0.864 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only |
| COPG1 | COPZ1 | 0.999 | 0.724 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction |
| SACM1L | COPG1 | 0.999 | 0.14 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| SACM1L | COPE | 0.999 | 0.096 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| SACM1L | COPZ1 | 0.999 | 0.12 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 gupta_WMM | |
| COPG2 | COPA | 0.999 | 0.76 |
structurally_consistent (P53618)
|
hein_WMM bioplex_WMM bioplex3_WMM boldt hein () fraction boldt_WMM treiber_WMM |
| COPG2 | ARCN1 | 0.998 | 0.578 | hein_WMM bioplex_WMM bioplex3_WMM boldt fraction boldt_WMM treiber_WMM | |
| COPG2 | COPZ1 | 0.998 | 0.464 |
structurally_consistent (P53618)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| COPB2 | COPG2 | 0.998 | 0.812 | hein_WMM bioplex_WMM bioplex3_WMM boldt boldt_WMM treiber_WMM WMM_only | |
| ARCN1 | COPZ1 | 0.997 | 0.842 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| COPZ1 | COPA | 0.997 | 0.798 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM fraction boldt_WMM | |
| SACM1L | COPG2 | 0.997 | 0.2 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| COPB2 | COPZ1 | 0.996 | 0.916666666667 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction | |
| COPZ1 | COPB1 | 0.996 | 0.912 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM fraction |
| COPZ1 | COPE | 0.996 | 0.882 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM fraction treiber_WMM | |
| COPG1 | COPZ2 | 0.991 | 0.174 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| SACM1L | COPA | 0.988 | 0.302 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| COPZ2 | COPB1 | 0.987 | 0.332 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COPZ2 | COPA | 0.984 | 0.332 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COPB2 | COPZ2 | 0.984 | 0.37 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| COPZ2 | COPE | 0.983 | 0.264 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| ARCN1 | COPZ2 | 0.98 | 0.316 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| SACM1L | COPB2 | 0.968 | 0.456 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| SACM1L | ARCN1 | 0.93 | 0.126 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| SACM1L | COPB1 | 0.811 | 0.188 | hein_WMM bioplex_WMM bioplex3_WMM hein () gupta_WMM | |
| COPG2 | COPZ2 | 0.127 | 0.142 | bioplex3_HEK293 bioplex3_WMM WMM_only |
Related Complexes