hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04414.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MLXIP | MLX-interacting protein (Class E basic helix-loop-helix protein 36) (bHLHe36) (Transcriptional activator MondoA) | 5 | UniProt NCBI |
| MNT | Max-binding protein MNT (Class D basic helix-loop-helix protein 3) (bHLHd3) (Myc antagonist MNT) (Protein ROX) | 5 | UniProt NCBI |
| MLXIPL | Carbohydrate-responsive element-binding protein (ChREBP) (Class D basic helix-loop-helix protein 14) (bHLHd14) (MLX interactor) (MLX-interacting protein-like) (WS basic-helix-loop-helix leucine zipper protein) (WS-bHLH) (Williams-Beuren syndrome chromosomal region 14 protein) | 5 | UniProt NCBI |
| MLX | Max-like protein X (Class D basic helix-loop-helix protein 13) (bHLHd13) (Max-like bHLHZip protein) (Protein BigMax) (Transcription factor-like protein 4) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04931 | 5.19578118732e-05 | 0.75 | MLX MLXIP MLXIPL | Insulin resistance |
| WP:WP4396 | 0.000145521073611 | 0.75 | MLX MLXIP MLXIPL | Nonalcoholic fatty liver disease |
| KEGG:04932 | 0.000149305865271 | 0.75 | MLX MLXIP MLXIPL | Non-alcoholic fatty liver disease |
| REAC:R-HSA-163765 | 0.000215205765992 | 0.5 | MLXIPL MLX | ChREBP activates metabolic gene expression |
| REAC:R-HSA-163685 | 0.041644107744 | 0.5 | MLXIPL MLX | Integration of energy metabolism |
| HP:0004306 | 0.0458701548093 | 0.5 | MLXIPL MLX | Abnormal endocardium morphology |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| MLXIP | MLX | 1.0 | 0.114 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| MLXIPL | MLX | 0.999 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MNT | MLX | 0.998 | 0.13 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| MNT | MLXIPL | 0.916 | 0.096 | bioplex_WMM bioplex3_WMM WMM_only |
| MLXIP | MLXIPL | 0.911 | 0.09 | bioplex_WMM bioplex3_WMM WMM_only |
| MNT | MLXIP | 0.902 | 0.116 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes