hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04424.1
Complex Portal: CPX-19477
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25 (EC 6.3.2.n3) (Estrogen-responsive finger protein) (RING finger protein 147) (RING-type E3 ubiquitin transferase) (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM25) (Tripartite motif-containing protein 25) (Ubiquitin/ISG15-conjugating enzyme TRIM25) (Zinc finger protein 147) | 5 | UniProt NCBI |
| TREX2 | Three prime repair exonuclease 2 (EC 3.1.11.2) (3'-5' exonuclease TREX2) | 5 | UniProt NCBI |
| GGCT | Gamma-glutamylcyclotransferase (EC 4.3.2.9) (Cytochrome c-releasing factor 21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2717 | 0.0249718442456 | 0.333333333333 | TRIM25 | Ubiquitin E3 ligase (TRIM25, DDX58) |
| WP:WP4518 | 0.0496447587094 | 0.333333333333 | GGCT | Gamma glutamyl cycle for the biosynthesis and degradation of glutathione including diseases |
| CORUM:7357 | 0.0499402709677 | 0.333333333333 | TRIM25 | TRIM25-G3BP2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| TREX2 | GGCT | 0.954 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt_WMM WMM_only | ||
| TRIM25 | TREX2 | 0.952 | bioplex_WMM bioplex3_WMM WMM_only | ||
| TRIM25 | GGCT | 0.132 | 0.225285714286 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes