hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04427.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CENPK | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) | 5 | UniProt NCBI |
| CENPH | Centromere protein H (CENP-H) (Interphase centromere complex protein 35) | 5 | UniProt NCBI |
| CENPI | Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7394 | 3.85883376584e-08 | 1.0 | CENPK CENPH CENPI | CENP-H-I complex |
| CORUM:929 | 1.39947037908e-06 | 1.0 | CENPK CENPH CENPI | CEN complex |
| REAC:R-HSA-606279 | 1.67930110599e-05 | 1.0 | CENPK CENPH CENPI | Deposition of new CENPA-containing nucleosomes at the centromere |
| REAC:R-HSA-774815 | 1.67930110599e-05 | 1.0 | CENPK CENPH CENPI | Nucleosome assembly |
| GO:0000939 | 5.38272230028e-05 | 1.0 | CENPK CENPH CENPI | inner kinetochore |
| REAC:R-HSA-141424 | 5.85958968853e-05 | 1.0 | CENPK CENPH CENPI | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 5.85958968853e-05 | 1.0 | CENPK CENPH CENPI | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-69618 | 9.52596267282e-05 | 1.0 | CENPK CENPH CENPI | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9648025 | 0.00010924835892 | 1.0 | CENPK CENPH CENPI | EML4 and NUDC in mitotic spindle formation |
| REAC:R-HSA-2500257 | 0.000134372084608 | 1.0 | CENPK CENPH CENPI | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-73886 | 0.000155553488805 | 1.0 | CENPK CENPH CENPI | Chromosome Maintenance |
| REAC:R-HSA-5663220 | 0.000174817158202 | 1.0 | CENPK CENPH CENPI | RHO GTPases Activate Formins |
| CORUM:7388 | 0.000225453649047 | 0.666666666667 | CENPH CENPI | CENP-A nucleosomal complex |
| CORUM:1179 | 0.000266433060428 | 0.666666666667 | CENPK CENPH | CENP-A NAC-CAD complex |
| REAC:R-HSA-2467813 | 0.000476579961334 | 1.0 | CENPK CENPH CENPI | Separation of Sister Chromatids |
| REAC:R-HSA-68877 | 0.000567791814488 | 1.0 | CENPK CENPH CENPI | Mitotic Prometaphase |
| REAC:R-HSA-68882 | 0.000850835472921 | 1.0 | CENPK CENPH CENPI | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.000862385275721 | 1.0 | CENPK CENPH CENPI | Mitotic Metaphase and Anaphase |
| REAC:R-HSA-69620 | 0.00167079914838 | 1.0 | CENPK CENPH CENPI | Cell Cycle Checkpoints |
| REAC:R-HSA-195258 | 0.00199644124929 | 1.0 | CENPK CENPH CENPI | RHO GTPase Effectors |
| REAC:R-HSA-68886 | 0.00447254250064 | 1.0 | CENPK CENPH CENPI | M Phase |
| REAC:R-HSA-69278 | 0.0112530904983 | 1.0 | CENPK CENPH CENPI | Cell Cycle, Mitotic |
| REAC:R-HSA-194315 | 0.0193529117228 | 1.0 | CENPK CENPH CENPI | Signaling by Rho GTPases |
| REAC:R-HSA-9716542 | 0.02067413488 | 1.0 | CENPK CENPH CENPI | Signaling by Rho GTPases, Miro GTPases and RHOBTB3 |
| REAC:R-HSA-1640170 | 0.0209648611427 | 1.0 | CENPK CENPH CENPI | Cell Cycle |
| GO:0000776 | 0.0402954436201 | 1.0 | CENPK CENPH CENPI | kinetochore |
| GO:0000779 | 0.0439566559847 | 1.0 | CENPK CENPH CENPI | condensed chromosome, centromeric region |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CENPK | CENPH | 1.0 | 0.43 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () bioplex3_HCT116 |
| CENPH | CENPI | 1.0 | 0.328 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| CENPK | CENPI | 0.999 | 0.206 | hein_WMM bioplex3_HEK293 bioplex3_WMM hein () |
Related Complexes