hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04432.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CREBBP | CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) | 5 | UniProt NCBI |
| CCN2 | CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) | 5 | UniProt NCBI |
| EP300 | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001042 | 3.41752350426e-06 | 1.0 | CREBBP EP300 | High axial triradius |
| HP:0008107 | 3.41752350426e-06 | 1.0 | CREBBP EP300 | Plantar crease between first and second toes |
| HP:0034227 | 3.41752350426e-06 | 1.0 | CREBBP EP300 | Aortic isthmus hypoplasia |
| HP:0005895 | 3.41752350426e-06 | 1.0 | CREBBP EP300 | Radial deviation of thumb terminal phalanx |
| CORUM:571 | 5.12628525639e-06 | 1.0 | CREBBP EP300 | p300-CBP-p270 complex |
| CORUM:4 | 5.12628525639e-06 | 1.0 | CREBBP EP300 | Multisubunit ACTR coactivator complex |
| HP:0005363 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Humoral immunodeficiency |
| HP:0005322 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Prominent nasal septum |
| HP:5200232 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Phobia |
| HP:0000756 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Agoraphobia |
| HP:0006200 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Widened distal phalanges |
| HP:0008752 | 1.02525705128e-05 | 1.0 | CREBBP EP300 | Laryngeal cartilage malformation |
| REAC:R-HSA-3134973 | 1.70876175213e-05 | 1.0 | CREBBP EP300 | LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production |
| CORUM:2638 | 1.70876175213e-05 | 1.0 | CREBBP EP300 | HES1 promoter corepressor complex |
| HP:0001128 | 2.05051410255e-05 | 1.0 | CREBBP EP300 | Trichiasis |
| HP:0410266 | 2.05051410255e-05 | 1.0 | CREBBP EP300 | Visceral hemangioma |
| HP:0031207 | 2.05051410255e-05 | 1.0 | CREBBP EP300 | Hepatic hemangioma |
| HP:0010775 | 2.05051410255e-05 | 1.0 | CREBBP EP300 | Vascular ring |
| HP:0011087 | 2.05051410255e-05 | 1.0 | CREBBP EP300 | Talon cusp |
| HP:0033777 | 3.41752350426e-05 | 1.0 | CREBBP EP300 | Supernumerary cusp |
| HP:0030421 | 3.41752350426e-05 | 1.0 | CREBBP EP300 | Epididymal neoplasm |
| HP:0009715 | 3.41752350426e-05 | 1.0 | CREBBP EP300 | Papillary cystadenoma of the epididymis |
| CORUM:570 | 3.58839967947e-05 | 1.0 | CREBBP EP300 | p300-CBP-p270-SWI/SNF complex |
| REAC:R-HSA-1234158 | 3.58839967947e-05 | 1.0 | CREBBP EP300 | Regulation of gene expression by Hypoxia-inducible Factor |
| REAC:R-HSA-9818028 | 4.78453290596e-05 | 1.0 | CREBBP EP300 | NFE2L2 regulates pentose phosphate pathway genes |
| HP:0004411 | 5.12628525639e-05 | 1.0 | CREBBP EP300 | Deviated nasal septum |
| HP:0100852 | 5.12628525639e-05 | 1.0 | CREBBP EP300 | Abnormal fear-induced behavior |
| HP:0002700 | 5.12628525639e-05 | 1.0 | CREBBP EP300 | Large foramen magnum |
| HP:0030434 | 7.17679935894e-05 | 1.0 | CREBBP EP300 | Pilomatrixoma |
| HP:0011335 | 7.17679935894e-05 | 1.0 | CREBBP EP300 | Frontal hirsutism |
| WP:WP3657 | 7.2783930122e-05 | 1.0 | CREBBP EP300 | Hematopoietic stem cell gene regulation by GABP alpha beta complex |
| REAC:R-HSA-8866907 | 7.68942788458e-05 | 1.0 | CREBBP EP300 | Activation of the TFAP2 (AP-2) family of transcription factors |
| REAC:R-HSA-9617629 | 7.68942788458e-05 | 1.0 | CREBBP EP300 | Regulation of FOXO transcriptional activity by acetylation |
| REAC:R-HSA-210744 | 9.39818963671e-05 | 1.0 | CREBBP EP300 | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| REAC:R-HSA-8941856 | 9.39818963671e-05 | 1.0 | CREBBP EP300 | RUNX3 regulates NOTCH signaling |
| HP:0031251 | 9.56906581192e-05 | 1.0 | CREBBP EP300 | Abnormal subclavian artery morphology |
| HP:0002341 | 9.56906581192e-05 | 1.0 | CREBBP EP300 | Cervical cord compression |
| HP:0010314 | 0.000123030846153 | 1.0 | CREBBP EP300 | Premature thelarche |
| REAC:R-HSA-3371568 | 0.000133283416666 | 1.0 | CREBBP EP300 | Attenuation phase |
| HP:0002697 | 0.000153788557692 | 1.0 | CREBBP EP300 | Parietal foramina |
| HP:0007086 | 0.000153788557692 | 1.0 | CREBBP EP300 | Social and occupational deterioration |
| HP:0009714 | 0.000153788557692 | 1.0 | CREBBP EP300 | Abnormal epididymis morphology |
| REAC:R-HSA-918233 | 0.000155497319444 | 1.0 | CREBBP EP300 | TRAF3-dependent IRF activation pathway |
| WP:WP3414 | 0.000172808629413 | 1.0 | CREBBP EP300 | Initiation of transcription and translation elongation at the HIV 1 LTR |
| REAC:R-HSA-9013695 | 0.000179419983974 | 1.0 | CREBBP EP300 | NOTCH4 Intracellular Domain Regulates Transcription |
| KEGG:04330 | 0.000183378615366 | 1.0 | CREBBP EP300 | Notch signaling pathway |
| HP:0000321 | 0.000187963792734 | 1.0 | CREBBP EP300 | Square face |
| HP:0000273 | 0.000187963792734 | 1.0 | CREBBP EP300 | Facial grimacing |
| HP:0010562 | 0.000187963792734 | 1.0 | CREBBP EP300 | Keloids |
| REAC:R-HSA-9818027 | 0.000205051410255 | 1.0 | CREBBP EP300 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| REAC:R-HSA-1368082 | 0.000205051410255 | 1.0 | CREBBP EP300 | RORA activates gene expression |
| REAC:R-HSA-9614657 | 0.000205051410255 | 1.0 | CREBBP EP300 | FOXO-mediated transcription of cell death genes |
| WP:WP4241 | 0.000211115961056 | 1.0 | CREBBP EP300 | Type 2 papillary renal cell carcinoma |
| HP:0010066 | 0.000225556551281 | 1.0 | CREBBP EP300 | Duplication of phalanx of hallux |
| HP:0010181 | 0.000225556551281 | 1.0 | CREBBP EP300 | Duplication of phalanx of toe |
| HP:0012304 | 0.000225556551281 | 1.0 | CREBBP EP300 | Hypoplastic aortic arch |
| KEGG:04720 | 0.000232637232791 | 1.0 | CREBBP EP300 | Long-term potentiation |
| KEGG:03250 | 0.00025946123238 | 1.0 | CREBBP EP300 | Viral life cycle - HIV-1 |
| REAC:R-HSA-9793380 | 0.000261440548076 | 1.0 | CREBBP EP300 | Formation of paraxial mesoderm |
| HP:0009937 | 0.000310994638887 | 1.0 | CREBBP EP300 | Facial hirsutism |
| REAC:R-HSA-9013508 | 0.000324664732905 | 1.0 | CREBBP EP300 | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-5621575 | 0.000324664732905 | 1.0 | CREBBP EP300 | CD209 (DC-SIGN) signaling |
| KEGG:05211 | 0.000338144964505 | 1.0 | CREBBP EP300 | Renal cell carcinoma |
| HP:0012842 | 0.000358839967947 | 1.0 | CREBBP EP300 | Skin appendage neoplasm |
| WP:WP560 | 0.000384350227487 | 1.0 | CREBBP EP300 | TGF beta receptor signaling |
| HP:0001869 | 0.000410102820511 | 1.0 | CREBBP EP300 | Deep plantar creases |
| HP:0002699 | 0.000410102820511 | 1.0 | CREBBP EP300 | Abnormal foramen magnum morphology |
| HP:0000559 | 0.000410102820511 | 1.0 | CREBBP EP300 | Corneal scarring |
| WP:WP4816 | 0.000421380648075 | 1.0 | CREBBP EP300 | TGF beta receptor signaling in skeletal dysplasias |
| REAC:R-HSA-3371571 | 0.000432316723289 | 1.0 | CREBBP EP300 | HSF1-dependent transactivation |
| HP:0000387 | 0.000464783196579 | 1.0 | CREBBP EP300 | Absent earlobe |
| HP:0009889 | 0.000464783196579 | 1.0 | CREBBP EP300 | Localized hirsutism |
| HP:0006349 | 0.000464783196579 | 1.0 | CREBBP EP300 | Agenesis of permanent teeth |
| HP:0002869 | 0.000464783196579 | 1.0 | CREBBP EP300 | Flared iliac wing |
| REAC:R-HSA-186712 | 0.000512628525639 | 1.0 | CREBBP EP300 | Regulation of beta-cell development |
| HP:0010059 | 0.000522881096151 | 1.0 | CREBBP EP300 | Broad hallux phalanx |
| KEGG:03083 | 0.000526725810094 | 1.0 | CREBBP EP300 | Polycomb repressive complex |
| KEGG:04916 | 0.000553224670293 | 1.0 | CREBBP EP300 | Melanogenesis |
| HP:0002866 | 0.000584396519228 | 1.0 | CREBBP EP300 | Hypoplastic iliac wing |
| HP:0011682 | 0.000584396519228 | 1.0 | CREBBP EP300 | Perimembranous ventricular septal defect |
| KEGG:04520 | 0.0005941922333 | 1.0 | CREBBP EP300 | Adherens junction |
| KEGG:04350 | 0.000608173227025 | 1.0 | CREBBP EP300 | TGF-beta signaling pathway |
| HP:0020206 | 0.000649329465809 | 1.0 | CREBBP EP300 | Simple ear |
| KEGG:05215 | 0.000651091626366 | 1.0 | CREBBP EP300 | Prostate cancer |
| KEGG:04922 | 0.000680516741066 | 1.0 | CREBBP EP300 | Glucagon signaling pathway |
| REAC:R-HSA-933541 | 0.000693757271364 | 1.0 | CREBBP EP300 | TRAF6 mediated IRF7 activation |
| WP:WP3651 | 0.00070357799118 | 1.0 | CREBBP EP300 | Pathways affected in adenoid cystic carcinoma |
| HP:0009836 | 0.000717679935894 | 1.0 | CREBBP EP300 | Broad distal phalanx of finger |
| HP:0002236 | 0.000717679935894 | 1.0 | CREBBP EP300 | Frontal upsweep of hair |
| HP:0000049 | 0.000717679935894 | 1.0 | CREBBP EP300 | Shawl scrotum |
| HP:0000419 | 0.000717679935894 | 1.0 | CREBBP EP300 | Abnormal nasal septum morphology |
| WP:WP5158 | 0.000728264938239 | 1.0 | CREBBP EP300 | Urotensin II mediated signaling pathway |
| KEGG:04066 | 0.00078862558789 | 1.0 | CREBBP EP300 | HIF-1 signaling pathway |
| HP:0009834 | 0.000789447929484 | 1.0 | CREBBP EP300 | Abnormal proximal phalanx morphology of the hand |
| KEGG:04935 | 0.000804719987643 | 1.0 | CREBBP EP300 | Growth hormone synthesis, secretion and action |
| HP:0011587 | 0.000864633446577 | 1.0 | CREBBP EP300 | Abnormal branching pattern of the aortic arch |
| KEGG:04919 | 0.000887630531825 | 1.0 | CREBBP EP300 | Thyroid hormone signaling pathway |
| REAC:R-HSA-8864260 | 0.000902226205124 | 1.0 | CREBBP EP300 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| HP:0002183 | 0.000943236487175 | 1.0 | CREBBP EP300 | Phonophobia |
| HP:0002000 | 0.000943236487175 | 1.0 | CREBBP EP300 | Short columella |
| HP:0011229 | 0.000943236487175 | 1.0 | CREBBP EP300 | Broad eyebrow |
| HP:0002696 | 0.00102525705128 | 1.0 | CREBBP EP300 | Abnormal parietal bone morphology |
| HP:0003396 | 0.00102525705128 | 1.0 | CREBBP EP300 | Syringomyelia |
| KEGG:04068 | 0.00102874102663 | 1.0 | CREBBP EP300 | FoxO signaling pathway |
| HP:0009617 | 0.00111069513888 | 1.0 | CREBBP EP300 | Abnormality of the distal phalanx of the thumb |
| REAC:R-HSA-9758941 | 0.00113803532692 | 1.0 | CREBBP EP300 | Gastrulation |
| WP:WP4018 | 0.00118114272566 | 1.0 | CREBBP EP300 | Clear cell renal cell carcinoma pathways |
| HP:0002835 | 0.00119955074999 | 1.0 | CREBBP EP300 | Aspiration |
| REAC:R-HSA-3899300 | 0.00120125951175 | 1.0 | CREBBP EP300 | SUMOylation of transcription cofactors |
| REAC:R-HSA-9012852 | 0.00126619245833 | 1.0 | CREBBP EP300 | Signaling by NOTCH3 |
| HP:0010721 | 0.00129182388461 | 1.0 | CREBBP EP300 | Abnormal hair whorl |
| HP:0011044 | 0.00129182388461 | 1.0 | CREBBP EP300 | Abnormal number of permanent teeth |
| HP:0005743 | 0.00129182388461 | 1.0 | CREBBP EP300 | Avascular necrosis of the capital femoral epiphysis |
| REAC:R-HSA-2122947 | 0.00133283416666 | 1.0 | CREBBP EP300 | NOTCH1 Intracellular Domain Regulates Transcription |
| KEGG:04630 | 0.00138428094844 | 1.0 | CREBBP EP300 | JAK-STAT signaling pathway |
| HP:0000579 | 0.00138751454273 | 1.0 | CREBBP EP300 | Nasolacrimal duct obstruction |
| HP:0010621 | 0.00138751454273 | 1.0 | CREBBP EP300 | Cutaneous syndactyly of toes |
| WP:WP138 | 0.00141354053763 | 1.0 | CREBBP EP300 | Androgen receptor signaling pathway |
| REAC:R-HSA-9707616 | 0.00147124386858 | 1.0 | CREBBP EP300 | Heme signaling |
| HP:0002370 | 0.00148662272435 | 1.0 | CREBBP EP300 | Poor coordination |
| HP:0001747 | 0.00158914842948 | 1.0 | CREBBP EP300 | Accessory spleen |
| HP:0000034 | 0.00158914842948 | 1.0 | CREBBP EP300 | Hydrocele testis |
| HP:5200060 | 0.00158914842948 | 1.0 | CREBBP EP300 | Auditory hypersensitivity |
| KEGG:05164 | 0.0016738175743 | 1.0 | CREBBP EP300 | Influenza A |
| HP:0002176 | 0.00169509165811 | 1.0 | CREBBP EP300 | Spinal cord compression |
| HP:0005374 | 0.00169509165811 | 1.0 | CREBBP EP300 | Cellular immunodeficiency |
| KEGG:05152 | 0.001720800216 | 1.0 | CREBBP EP300 | Tuberculosis |
| KEGG:05161 | 0.00176843313648 | 1.0 | CREBBP EP300 | Hepatitis B |
| KEGG:05206 | 0.00176843313648 | 1.0 | CREBBP EP300 | MicroRNAs in cancer |
| HP:0004383 | 0.00180445241025 | 1.0 | CREBBP EP300 | Hypoplastic left heart |
| HP:0011470 | 0.00180445241025 | 1.0 | CREBBP EP300 | Nasogastric tube feeding in infancy |
| KEGG:04310 | 0.00181671633574 | 1.0 | CREBBP EP300 | Wnt signaling pathway |
| KEGG:04110 | 0.00184110178991 | 1.0 | CREBBP EP300 | Cell cycle |
| REAC:R-HSA-2644606 | 0.00184717145405 | 1.0 | CREBBP EP300 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| REAC:R-HSA-2894862 | 0.00184717145405 | 1.0 | CREBBP EP300 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| REAC:R-HSA-2894858 | 0.00184717145405 | 1.0 | CREBBP EP300 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644602 | 0.00184717145405 | 1.0 | CREBBP EP300 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| REAC:R-HSA-2644603 | 0.00184717145405 | 1.0 | CREBBP EP300 | Signaling by NOTCH1 in Cancer |
| WP:WP399 | 0.0018604594068 | 1.0 | CREBBP EP300 | Wnt signaling pathway and pluripotency |
| KEGG:04024 | 0.00201635192055 | 1.0 | CREBBP EP300 | cAMP signaling pathway |
| HP:0000695 | 0.00203342648503 | 1.0 | CREBBP EP300 | Natal tooth |
| HP:0045017 | 0.00203342648503 | 1.0 | CREBBP EP300 | Congenital malformation of the left heart |
| HP:0010057 | 0.00203342648503 | 1.0 | CREBBP EP300 | Abnormal hallux phalanx morphology |
| HP:0005306 | 0.00227607065384 | 1.0 | CREBBP EP300 | Capillary hemangioma |
| HP:0007099 | 0.00227607065384 | 1.0 | CREBBP EP300 | Chiari type I malformation |
| HP:0010174 | 0.00227607065384 | 1.0 | CREBBP EP300 | Broad phalanx of the toes |
| HP:0000946 | 0.00227607065384 | 1.0 | CREBBP EP300 | Hypoplastic ilia |
| KEGG:05167 | 0.00228052767407 | 1.0 | CREBBP EP300 | Kaposi sarcoma-associated herpesvirus infection |
| HP:0001961 | 0.00240251902349 | 1.0 | CREBBP EP300 | Hypoplastic heart |
| HP:0100561 | 0.00240251902349 | 1.0 | CREBBP EP300 | Spinal cord lesion |
| HP:0100323 | 0.00240251902349 | 1.0 | CREBBP EP300 | Juvenile aseptic necrosis |
| HP:0005324 | 0.00253238491666 | 1.0 | CREBBP EP300 | Disturbance of facial expression |
| HP:0000742 | 0.00253238491666 | 1.0 | CREBBP EP300 | Self-mutilation |
| HP:0001212 | 0.00266566833332 | 1.0 | CREBBP EP300 | Prominent fingertip pads |
| KEGG:05203 | 0.00279701159341 | 1.0 | CREBBP EP300 | Viral carcinogenesis |
| HP:0002858 | 0.00280236927349 | 1.0 | CREBBP EP300 | Meningioma |
| HP:0011481 | 0.00280236927349 | 1.0 | CREBBP EP300 | Abnormal lacrimal duct morphology |
| HP:0003083 | 0.00280236927349 | 1.0 | CREBBP EP300 | Dislocated radial head |
| GO:0018076 | 0.0028092043205 | 1.0 | CREBBP EP300 | N-terminal peptidyl-lysine acetylation |
| WP:WP4217 | 0.00283899891178 | 1.0 | CREBBP EP300 | Ebola virus infection in host |
| REAC:R-HSA-1834949 | 0.00292369135789 | 1.0 | CREBBP EP300 | Cytosolic sensors of pathogen-associated DNA |
| REAC:R-HSA-1980143 | 0.00292369135789 | 1.0 | CREBBP EP300 | Signaling by NOTCH1 |
| WP:WP4673 | 0.00293817233703 | 1.0 | CREBBP EP300 | Male infertility |
| HP:0006288 | 0.00294248773717 | 1.0 | CREBBP EP300 | Advanced eruption of teeth |
| HP:0000446 | 0.00294248773717 | 1.0 | CREBBP EP300 | Narrow nasal bridge |
| HP:0011298 | 0.00294248773717 | 1.0 | CREBBP EP300 | Prominent digit pad |
| WP:WP366 | 0.00298839750519 | 1.0 | CREBBP EP300 | TGF beta signaling pathway |
| REAC:R-HSA-9614085 | 0.00302450830127 | 1.0 | CREBBP EP300 | FOXO-mediated transcription |
| WP:WP706 | 0.00309012475255 | 1.0 | CREBBP EP300 | Sudden infant death syndrome SIDS susceptibility pathways |
| REAC:R-HSA-400253 | 0.0031270340064 | 1.0 | CREBBP EP300 | Circadian Clock |
| KEGG:05166 | 0.00317059675131 | 1.0 | CREBBP EP300 | Human T-cell leukemia virus 1 infection |
| HP:0003995 | 0.00323297723503 | 1.0 | CREBBP EP300 | Abnormality of the radial head |
| HP:0008689 | 0.00338334826922 | 1.0 | CREBBP EP300 | Bilateral cryptorchidism |
| HP:0011069 | 0.00338334826922 | 1.0 | CREBBP EP300 | Supernumerary tooth |
| HP:0000735 | 0.0036943429081 | 1.0 | CREBBP EP300 | Impaired social interactions |
| HP:0009906 | 0.0038549665128 | 1.0 | CREBBP EP300 | Aplasia/Hypoplasia of the earlobes |
| WP:WP4666 | 0.00396523446209 | 1.0 | CREBBP EP300 | Hepatitis B infection |
| HP:0009765 | 0.00401900764101 | 1.0 | CREBBP EP300 | Low hanging columella |
| HP:0011063 | 0.00401900764101 | 1.0 | CREBBP EP300 | Abnormal incisor morphology |
| HP:0100744 | 0.00401900764101 | 1.0 | CREBBP EP300 | Abnormality of the humeroradial joint |
| HP:0011867 | 0.00401900764101 | 1.0 | CREBBP EP300 | Abnormal iliac wing morphology |
| REAC:R-HSA-1234174 | 0.00412665963139 | 1.0 | CREBBP EP300 | Cellular response to hypoxia |
| HP:0001650 | 0.00418646629272 | 1.0 | CREBBP EP300 | Aortic valve stenosis |
| HP:0025269 | 0.00418646629272 | 1.0 | CREBBP EP300 | Panic attack |
| REAC:R-HSA-9013694 | 0.00449062588459 | 1.0 | CREBBP EP300 | Signaling by NOTCH4 |
| REAC:R-HSA-381340 | 0.00474181386216 | 1.0 | CREBBP EP300 | Transcriptional regulation of white adipocyte differentiation |
| REAC:R-HSA-168928 | 0.00474181386216 | 1.0 | CREBBP EP300 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| REAC:R-HSA-1912408 | 0.00486997099357 | 1.0 | CREBBP EP300 | Pre-NOTCH Transcription and Translation |
| HP:0012303 | 0.00489047613459 | 1.0 | CREBBP EP300 | Abnormal aortic arch morphology |
| REAC:R-HSA-201722 | 0.00499983688673 | 1.0 | CREBBP EP300 | Formation of the beta-catenin:TCF transactivating complex |
| REAC:R-HSA-9759194 | 0.00513141154164 | 1.0 | CREBBP EP300 | Nuclear events mediated by NFE2L2 |
| HP:0005301 | 0.00526298619656 | 1.0 | CREBBP EP300 | Persistent left superior vena cava |
| HP:0012760 | 0.00526298619656 | 1.0 | CREBBP EP300 | Reduced social reciprocity |
| HP:0025575 | 0.00564916635254 | 1.0 | CREBBP EP300 | Abnormal superior vena cava morphology |
| HP:0002870 | 0.00584738271579 | 1.0 | CREBBP EP300 | Obstructive sleep apnea |
| KEGG:05016 | 0.00594761227231 | 1.0 | CREBBP EP300 | Huntington disease |
| REAC:R-HSA-3371556 | 0.0061002794551 | 1.0 | CREBBP EP300 | Cellular response to heat stress |
| HP:0001845 | 0.00625406801279 | 1.0 | CREBBP EP300 | Overlapping toe |
| HP:0005345 | 0.00646253694655 | 1.0 | CREBBP EP300 | Abnormal vena cava morphology |
| REAC:R-HSA-8878159 | 0.00654113998715 | 1.0 | CREBBP EP300 | Transcriptional regulation by RUNX3 |
| HP:0000022 | 0.00667442340382 | 1.0 | CREBBP EP300 | Abnormal male internal genitalia morphology |
| HP:0010055 | 0.00667442340382 | 1.0 | CREBBP EP300 | Broad hallux |
| HP:0002999 | 0.00667442340382 | 1.0 | CREBBP EP300 | Patellar dislocation |
| HP:0000614 | 0.00688972738458 | 1.0 | CREBBP EP300 | Abnormal nasolacrimal system morphology |
| KEGG:05165 | 0.00700203931066 | 1.0 | CREBBP EP300 | Human papillomavirus infection |
| REAC:R-HSA-1912422 | 0.00715287669441 | 1.0 | CREBBP EP300 | Pre-NOTCH Expression and Processing |
| HP:0002002 | 0.00733058791663 | 1.0 | CREBBP EP300 | Deep philtrum |
| HP:0000987 | 0.00755614446791 | 1.0 | CREBBP EP300 | Atypical scarring of skin |
| HP:0010574 | 0.0077851185427 | 1.0 | CREBBP EP300 | Abnormality of the epiphysis of the femoral head |
| HP:0003042 | 0.00801751014099 | 1.0 | CREBBP EP300 | Elbow dislocation |
| HP:0030890 | 0.00801751014099 | 1.0 | CREBBP EP300 | Hyperintensity of cerebral white matter on MRI |
| HP:0010051 | 0.00801751014099 | 1.0 | CREBBP EP300 | Deviation of the hallux |
| HP:0003298 | 0.00825331926278 | 1.0 | CREBBP EP300 | Spina bifida occulta |
| HP:0006499 | 0.00825331926278 | 1.0 | CREBBP EP300 | Abnormal femoral epiphysis morphology |
| REAC:R-HSA-1989781 | 0.00828920325958 | 1.0 | CREBBP EP300 | PPARA activates gene expression |
| REAC:R-HSA-400206 | 0.00845837067304 | 1.0 | CREBBP EP300 | Regulation of lipid metabolism by PPARalpha |
| HP:0001956 | 0.00849254590808 | 1.0 | CREBBP EP300 | Truncal obesity |
| HP:0012725 | 0.00873519007688 | 1.0 | CREBBP EP300 | Cutaneous syndactyly |
| REAC:R-HSA-9755511 | 0.0091521279444 | 1.0 | CREBBP EP300 | KEAP1-NFE2L2 pathway |
| HP:0009799 | 0.009230730985 | 1.0 | CREBBP EP300 | Supernumerary spleens |
| HP:0001837 | 0.009230730985 | 1.0 | CREBBP EP300 | Broad toe |
| HP:0001601 | 0.009230730985 | 1.0 | CREBBP EP300 | Laryngomalacia |
| HP:0006500 | 0.00948362772432 | 1.0 | CREBBP EP300 | Abnormal lower limb epiphysis morphology |
| REAC:R-HSA-5619507 | 0.0095092591506 | 1.0 | CREBBP EP300 | Activation of HOX genes during differentiation |
| REAC:R-HSA-5617472 | 0.0095092591506 | 1.0 | CREBBP EP300 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| HP:0003368 | 0.00999967377346 | 1.0 | CREBBP EP300 | Abnormal femoral head morphology |
| HP:0001211 | 0.00999967377346 | 1.0 | CREBBP EP300 | Abnormal fingertip morphology |
| HP:0030310 | 0.0102628230833 | 1.0 | CREBBP EP300 | Upper extremity joint dislocation |
| HP:0002867 | 0.0105293899166 | 1.0 | CREBBP EP300 | Abnormal ilium morphology |
| HP:0000260 | 0.0105293899166 | 1.0 | CREBBP EP300 | Wide anterior fontanel |
| HP:0000444 | 0.0105293899166 | 1.0 | CREBBP EP300 | Convex nasal ridge |
| HP:0011304 | 0.0107993742735 | 1.0 | CREBBP EP300 | Broad thumb |
| HP:0010885 | 0.0107993742735 | 1.0 | CREBBP EP300 | Avascular necrosis |
| HP:0000270 | 0.0110727761538 | 1.0 | CREBBP EP300 | Delayed cranial suture closure |
| HP:0009929 | 0.0113495955576 | 1.0 | CREBBP EP300 | Abnormal columella morphology |
| HP:0003745 | 0.0122005589102 | 1.0 | CREBBP EP300 | Sporadic |
| REAC:R-HSA-5621481 | 0.0122005589102 | 1.0 | CREBBP EP300 | C-type lectin receptors (CLRs) |
| HP:0010785 | 0.0124910484081 | 1.0 | CREBBP EP300 | Gonadal neoplasm |
| HP:0000676 | 0.0124910484081 | 1.0 | CREBBP EP300 | Abnormality of the incisor |
| HP:0006297 | 0.0124910484081 | 1.0 | CREBBP EP300 | Enamel hypoplasia |
| HP:0001852 | 0.0127849554294 | 1.0 | CREBBP EP300 | Sandal gap |
| HP:0100699 | 0.0133830220427 | 1.0 | CREBBP EP300 | Scarring |
| REAC:R-HSA-9018519 | 0.0136718027788 | 1.0 | CREBBP EP300 | Estrogen-dependent gene expression |
| REAC:R-HSA-3214847 | 0.0141075370256 | 1.0 | CREBBP EP300 | HATs acetylate histones |
| HP:0002308 | 0.0143057533888 | 1.0 | CREBBP EP300 | Chiari malformation |
| HP:0000448 | 0.0146201655512 | 1.0 | CREBBP EP300 | Prominent nose |
| HP:0003045 | 0.0149379952371 | 1.0 | CREBBP EP300 | Abnormal patella morphology |
| HP:0012450 | 0.0149379952371 | 1.0 | CREBBP EP300 | Chronic constipation |
| HP:0100498 | 0.0152592424465 | 1.0 | CREBBP EP300 | Deviation of toes |
| HP:0012368 | 0.0152592424465 | 1.0 | CREBBP EP300 | Flat face |
| KEGG:05200 | 0.0161326036311 | 1.0 | CREBBP EP300 | Pathways in cancer |
| HP:0009768 | 0.0162434892157 | 1.0 | CREBBP EP300 | Broad phalanges of the hand |
| HP:0001647 | 0.0165784065192 | 1.0 | CREBBP EP300 | Bicuspid aortic valve |
| HP:0100835 | 0.0169167413461 | 1.0 | CREBBP EP300 | Benign neoplasm of the central nervous system |
| HP:0030141 | 0.0172584936965 | 1.0 | CREBBP EP300 | Abnormality of the posterior hairline |
| HP:0031567 | 0.0172584936965 | 1.0 | CREBBP EP300 | Abnormal aortic valve cusp morphology |
| HP:0012745 | 0.0172584936965 | 1.0 | CREBBP EP300 | Short palpebral fissure |
| HP:0002162 | 0.0172584936965 | 1.0 | CREBBP EP300 | Low posterior hairline |
| HP:0009778 | 0.0179522509679 | 1.0 | CREBBP EP300 | Short thumb |
| HP:0000045 | 0.0183042558888 | 1.0 | CREBBP EP300 | Abnormal scrotum morphology |
| HP:0001181 | 0.0186596783332 | 1.0 | CREBBP EP300 | Adducted thumb |
| HP:0034398 | 0.0193807757926 | 1.0 | CREBBP EP300 | Toe deformity |
| HP:0010161 | 0.0193807757926 | 1.0 | CREBBP EP300 | Abnormal toe phalanx morphology |
| HP:0000236 | 0.0193807757926 | 1.0 | CREBBP EP300 | Abnormality of the anterior fontanelle |
| HP:0000685 | 0.0193807757926 | 1.0 | CREBBP EP300 | Hypoplasia of teeth |
| HP:0006505 | 0.0197464508076 | 1.0 | CREBBP EP300 | Abnormal limb epiphysis morphology |
| HP:0001655 | 0.0201155433461 | 1.0 | CREBBP EP300 | Patent foramen ovale |
| HP:0000527 | 0.0201155433461 | 1.0 | CREBBP EP300 | Long eyelashes |
| HP:0001634 | 0.0201155433461 | 1.0 | CREBBP EP300 | Mitral valve prolapse |
| HP:0000787 | 0.020488053408 | 1.0 | CREBBP EP300 | Nephrolithiasis |
| REAC:R-HSA-3108232 | 0.0211937720117 | 1.0 | CREBBP EP300 | SUMO E3 ligases SUMOylate target proteins |
| HP:0000581 | 0.0212433261025 | 1.0 | CREBBP EP300 | Blepharophimosis |
| HP:0000957 | 0.0212433261025 | 1.0 | CREBBP EP300 | Cafe-au-lait spot |
| HP:0030047 | 0.0216260887349 | 1.0 | CREBBP EP300 | Abnormal lateral ventricle morphology |
| HP:0002414 | 0.0220122688909 | 1.0 | CREBBP EP300 | Spina bifida |
| HP:0001642 | 0.0220122688909 | 1.0 | CREBBP EP300 | Pulmonic stenosis |
| HP:0000363 | 0.0224018665704 | 1.0 | CREBBP EP300 | Abnormal earlobe morphology |
| REAC:R-HSA-2990846 | 0.0225607814134 | 1.0 | CREBBP EP300 | SUMOylation |
| HP:0000327 | 0.0227948817734 | 1.0 | CREBBP EP300 | Hypoplasia of the maxilla |
| HP:0100710 | 0.0227948817734 | 1.0 | CREBBP EP300 | Impulsivity |
| HP:0002896 | 0.0235911647499 | 1.0 | CREBBP EP300 | Neoplasm of the liver |
| HP:0001500 | 0.0235911647499 | 1.0 | CREBBP EP300 | Broad finger |
| HP:0000689 | 0.0235911647499 | 1.0 | CREBBP EP300 | Dental malocclusion |
| CORUM:5198 | 0.0249718442457 | 0.5 | CREBBP | CBP-RARA-RXRA-DNA complex, ligand stimulated |
| HP:0000678 | 0.0252247409849 | 1.0 | CREBBP EP300 | Dental crowding |
| HP:0006009 | 0.0256416788524 | 1.0 | CREBBP EP300 | Broad phalanx |
| HP:0010301 | 0.0260620342435 | 1.0 | CREBBP EP300 | Spinal dysraphism |
| HP:0009601 | 0.026485807158 | 1.0 | CREBBP EP300 | Aplasia/Hypoplasia of the thumb |
| HP:0000293 | 0.026485807158 | 1.0 | CREBBP EP300 | Full cheeks |
| HP:0002624 | 0.0277776310426 | 1.0 | CREBBP EP300 | Abnormal venous morphology |
| HP:0005622 | 0.0277776310426 | 1.0 | CREBBP EP300 | Broad long bones |
| HP:0031546 | 0.0277776310426 | 1.0 | CREBBP EP300 | Cardiac conduction abnormality |
| HP:0002566 | 0.0277776310426 | 1.0 | CREBBP EP300 | Intestinal malrotation |
| HP:0010787 | 0.0282150740512 | 1.0 | CREBBP EP300 | Genital neoplasm |
| REAC:R-HSA-9711123 | 0.0284560094582 | 1.0 | CREBBP EP300 | Cellular response to chemical stress |
| REAC:R-HSA-8939211 | 0.0290831250212 | 1.0 | CREBBP EP300 | ESR-mediated signaling |
| HP:0000294 | 0.0295479082178 | 1.0 | CREBBP EP300 | Low anterior hairline |
| HP:0010535 | 0.0295479082178 | 1.0 | CREBBP EP300 | Sleep apnea |
| HP:0000010 | 0.0295479082178 | 1.0 | CREBBP EP300 | Recurrent urinary tract infections |
| HP:0000722 | 0.0295479082178 | 1.0 | CREBBP EP300 | Compulsive behaviors |
| HP:0001680 | 0.0299990213204 | 1.0 | CREBBP EP300 | Coarctation of aorta |
| HP:5200283 | 0.0299990213204 | 1.0 | CREBBP EP300 | Sleep-related breathing disorders |
| HP:0001028 | 0.0304535519464 | 1.0 | CREBBP EP300 | Hemangioma |
| HP:0025423 | 0.0304535519464 | 1.0 | CREBBP EP300 | Abnormal larynx morphology |
| HP:0031654 | 0.0313728657691 | 1.0 | CREBBP EP300 | Abnormal pulmonary valve physiology |
| HP:0002099 | 0.0313728657691 | 1.0 | CREBBP EP300 | Asthma |
| HP:0000574 | 0.0313728657691 | 1.0 | CREBBP EP300 | Thick eyebrow |
| HP:0000326 | 0.0313728657691 | 1.0 | CREBBP EP300 | Abnormal maxilla morphology |
| HP:0410263 | 0.0318376489657 | 1.0 | CREBBP EP300 | Brain imaging abnormality |
| HP:0100742 | 0.0323058496858 | 1.0 | CREBBP EP300 | Vascular neoplasm |
| HP:0001633 | 0.0323058496858 | 1.0 | CREBBP EP300 | Abnormal mitral valve morphology |
| HP:0100872 | 0.0327774679293 | 1.0 | CREBBP EP300 | Abnormality of the plantar skin of foot |
| HP:0009832 | 0.0332525036964 | 1.0 | CREBBP EP300 | Abnormal distal phalanx morphology of finger |
| HP:0002705 | 0.033730956987 | 1.0 | CREBBP EP300 | High, narrow palate |
| HP:0012433 | 0.033730956987 | 1.0 | CREBBP EP300 | Abnormal social behavior |
| HP:0000826 | 0.033730956987 | 1.0 | CREBBP EP300 | Precocious puberty |
| HP:0000239 | 0.0342128278011 | 1.0 | CREBBP EP300 | Large fontanelles |
| HP:0100000 | 0.0342128278011 | 1.0 | CREBBP EP300 | Early onset of sexual maturation |
| HP:0001385 | 0.0351868219998 | 1.0 | CREBBP EP300 | Hip dysplasia |
| HP:0002788 | 0.0351868219998 | 1.0 | CREBBP EP300 | Recurrent upper respiratory tract infections |
| REAC:R-HSA-157118 | 0.0353816208396 | 1.0 | CREBBP EP300 | Signaling by NOTCH |
| REAC:R-HSA-201681 | 0.0364325093171 | 1.0 | CREBBP EP300 | TCF dependent signaling in response to WNT |
| GO:0006474 | 0.0365196561665 | 1.0 | CREBBP EP300 | N-terminal protein amino acid acetylation |
| HP:0031652 | 0.0371758206793 | 1.0 | CREBBP EP300 | Abnormal aortic valve physiology |
| REAC:R-HSA-8878171 | 0.0378576166184 | 1.0 | CREBBP EP300 | Transcriptional regulation by RUNX1 |
| HP:0000712 | 0.0387034536857 | 1.0 | CREBBP EP300 | Emotional lability |
| HP:0001646 | 0.0392194997349 | 1.0 | CREBBP EP300 | Abnormal aortic valve morphology |
| HP:0001739 | 0.0397389633075 | 1.0 | CREBBP EP300 | Abnormal nasopharynx morphology |
| HP:0001909 | 0.0402618444037 | 1.0 | CREBBP EP300 | Leukemia |
| HP:0000670 | 0.0402618444037 | 1.0 | CREBBP EP300 | Carious teeth |
| HP:0006705 | 0.0418509928331 | 1.0 | CREBBP EP300 | Abnormal atrioventricular valve morphology |
| HP:0000319 | 0.0423875440233 | 1.0 | CREBBP EP300 | Smooth philtrum |
| HP:0100006 | 0.042927512737 | 1.0 | CREBBP EP300 | Neoplasm of the central nervous system |
| WP:WP5342 | 0.0435328773163 | 0.5 | EP300 | Pathophysiological roles of DUX4 in FSHD1 |
| HP:0011039 | 0.0440177027348 | 1.0 | CREBBP EP300 | Abnormal helix morphology |
| HP:0005346 | 0.0451215628267 | 1.0 | CREBBP EP300 | Abnormal facial expression |
| HP:0100716 | 0.0456786191579 | 1.0 | CREBBP EP300 | Self-injurious behavior |
| HP:0002317 | 0.0456786191579 | 1.0 | CREBBP EP300 | Unsteady gait |
| HP:0033151 | 0.0468029843908 | 1.0 | CREBBP EP300 | Abnormal pharynx morphology |
| HP:0011328 | 0.0479410197177 | 1.0 | CREBBP EP300 | Abnormality of fontanelles |
| HP:0003366 | 0.0490927251387 | 1.0 | CREBBP EP300 | Abnormal femoral neck/head morphology |
| GO:1900034 | 0.0491610756088 | 1.0 | CREBBP EP300 | regulation of cellular response to heat |
| HP:0001844 | 0.0496737041344 | 1.0 | CREBBP EP300 | Abnormal hallux morphology |
| CORUM:1158 | 0.0499419797295 | 0.5 | EP300 | p33ING1b-p300 complex |
| CORUM:5573 | 0.0499419797295 | 0.5 | CREBBP | Stat1-alpha-dimer-CBP DNA-protein complex |
| CORUM:1160 | 0.0499419797295 | 0.5 | EP300 | ING1-p300-PCNA complex |
| CORUM:5375 | 0.0499419797295 | 0.5 | EP300 | EGR-EP300 complex |
| CORUM:5261 | 0.0499419797295 | 0.5 | EP300 | TCF4-CTNNB1-EP300 complex |
| CORUM:3750 | 0.0499419797295 | 0.5 | CREBBP | CREBBP-SMAD3 hexameric complex |
| CORUM:3749 | 0.0499419797295 | 0.5 | CREBBP | CREBBP-SMAD2 hexameric complex |
| CORUM:2958 | 0.0499419797295 | 0.5 | CREBBP | SMAD1-CBP complex |
| CORUM:2642 | 0.0499419797295 | 0.5 | EP300 | SMAD1-P300 complex |
| CORUM:2641 | 0.0499419797295 | 0.5 | CREBBP | CREBBP-KAT2B-MYOD1 complex |
| CORUM:1831 | 0.0499419797295 | 0.5 | EP300 | PIAS3-SMAD3-P300 complex |
| CORUM:6590 | 0.0499419797295 | 0.5 | CREBBP | FOXO3-CBP complex |
| CORUM:5264 | 0.0499419797295 | 0.5 | CREBBP | TCF4-CTNNB1-CREBBP complex |
| HP:0011238 | 0.0499436884913 | 0.5 | CREBBP | Prominent inferior crus of antihelix |
| HP:0011243 | 0.0499436884913 | 0.5 | CREBBP | Abnormality of inferior crus of antihelix |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| EP300 | CREBBP | 0.999 | 0.476 | bioplex_WMM bioplex3_WMM boldt youn_WMM fraction boldt_WMM |
| CCN2 | EP300 | 0.979 | 0.072 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| CCN2 | CREBBP | 0.811 | 0.048 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes