hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04433.1
Complex Portal: CPX-10773
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PHPT1 | 14 kDa phosphohistidine phosphatase (EC 3.9.1.3) (Phosphohistidine phosphatase 1) (PHPT1) (Protein histidine phosphatase) (PHP) (Protein janus-A homolog) | 5 | UniProt NCBI |
| GTF2IRD2 | General transcription factor II-I repeat domain-containing protein 2A (GTF2I repeat domain-containing protein 2A) (Transcription factor GTF2IRD2-alpha) | 4 | UniProt NCBI |
| GTF2I | General transcription factor II-I (GTFII-I) (TFII-I) (Bruton tyrosine kinase-associated protein 135) (BAP-135) (BTK-associated protein 135) (SRF-Phox1-interacting protein) (SPIN) (Williams-Beuren syndrome chromosomal region 6 protein) | 5 | UniProt NCBI |
| GTF2IRD2B | General transcription factor II-I repeat domain-containing protein 2B (GTF2I repeat domain-containing protein 2B) (Transcription factor GTF2IRD2-beta) | 3 | UniProt NCBI |
| MVD | Diphosphomevalonate decarboxylase (EC 4.1.1.33) (Mevalonate (diphospho)decarboxylase) (MDDase) (Mevalonate pyrophosphate decarboxylase) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001361 | 0.00979150178217 | 0.4 | GTF2IRD2 GTF2I | Nystagmus-induced head nodding |
| HP:0004428 | 0.0134337956242 | 0.4 | GTF2IRD2 GTF2I | Elfin facies |
| HP:0007720 | 0.0147751514018 | 0.4 | GTF2IRD2 GTF2I | Flat cornea |
| HP:0002183 | 0.0176485923371 | 0.4 | GTF2IRD2 GTF2I | Phonophobia |
| HP:0100025 | 0.0191806250585 | 0.4 | GTF2IRD2 GTF2I | Overfriendliness |
| HP:0010780 | 0.0191806250585 | 0.4 | GTF2IRD2 GTF2I | Hyperacusis |
| HP:0100817 | 0.0224351839587 | 0.4 | GTF2IRD2 GTF2I | Renovascular hypertension |
| HP:0002623 | 0.0224351839587 | 0.4 | GTF2IRD2 GTF2I | Overriding aorta |
| HP:0004381 | 0.0224351839587 | 0.4 | GTF2IRD2 GTF2I | Supravalvular aortic stenosis |
| HP:0002253 | 0.0259435594648 | 0.4 | GTF2IRD2 GTF2I | Colonic diverticula |
| HP:5200060 | 0.0297055420477 | 0.4 | GTF2IRD2 GTF2I | Auditory hypersensitivity |
| HP:0000125 | 0.0316815705386 | 0.4 | GTF2IRD2 GTF2I | Pelvic kidney |
| HP:0005222 | 0.0337209222644 | 0.4 | GTF2IRD2 GTF2I | Bowel diverticulosis |
| HP:0000015 | 0.0337209222644 | 0.4 | GTF2IRD2 GTF2I | Bladder diverticulum |
| HP:0001136 | 0.0337209222644 | 0.4 | GTF2IRD2 GTF2I | Retinal arteriolar tortuosity |
| HP:0004398 | 0.0402186552091 | 0.4 | GTF2IRD2 GTF2I | Peptic ulcer |
| HP:0200021 | 0.0402186552091 | 0.4 | GTF2IRD2 GTF2I | Down-sloping shoulders |
| HP:0005113 | 0.0402186552091 | 0.4 | GTF2IRD2 GTF2I | Aortic arch aneurysm |
| HP:0000075 | 0.0425110382594 | 0.4 | GTF2IRD2 GTF2I | Renal duplication |
| WP:WP4189 | 0.0429732972479 | 0.2 | MVD | Mevalonate arm of cholesterol biosynthesis pathway with inhibitors |
| HP:0004969 | 0.0448666137641 | 0.4 | GTF2IRD2 GTF2I | Peripheral pulmonary artery stenosis |
| HP:0010669 | 0.0472853555832 | 0.4 | GTF2IRD2 GTF2I | Hypoplasia of the zygomatic bone |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| GTF2IRD2 | GTF2IRD2B | 0.999 | bioplex () bioplex3_WMM bioplex3_HCT116 | ||
| PHPT1 | GTF2IRD2 | 0.998 | 0.03 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTF2IRD2 | GTF2I | 0.992 | 0.752 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTF2IRD2 | MVD | 0.989 | 0.042 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GTF2IRD2B | GTF2I | 0.939 | bioplex3_HEK293 bioplex () bioplex3_WMM | ||
| PHPT1 | GTF2IRD2B | 0.902 | bioplex3_WMM WMM_only | ||
| GTF2IRD2B | MVD | 0.893 | bioplex3_WMM WMM_only | ||
| PHPT1 | GTF2I | 0.353 | 0.038 | bioplex_WMM bioplex3_WMM WMM_only | |
| PHPT1 | MVD | 0.343 | 0.086 | bioplex3_WMM fraction | |
| MVD | GTF2I | 0.083 | 0.098 | bioplex3_WMM WMM_only |
Related Complexes