hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04434.1
Complex Portal: CPX-15113
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CASP8 | Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10] | 5 | UniProt NCBI |
| CFLAR | CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5798 | 5.12628525639e-06 | 1.0 | CFLAR CASP8 | Death induced signaling complex II (FADD, CASP8, CFLAR), cytosolic, CD95L induced |
| CORUM:5799 | 5.12628525639e-06 | 1.0 | CFLAR CASP8 | DISC complex (FAS, FADD, CASP8, CFLAR), membrane-associated, CD95L induced |
| CORUM:5749 | 5.12628525639e-06 | 1.0 | CFLAR CASP8 | MRIT complex |
| REAC:R-HSA-75158 | 3.58839967947e-05 | 1.0 | CFLAR CASP8 | TRAIL signaling |
| WP:WP2507 | 7.2783930122e-05 | 1.0 | CFLAR CASP8 | Nanomaterial induced apoptosis |
| WP:WP314 | 0.000299222823835 | 1.0 | CFLAR CASP8 | Fas ligand pathway and stress induction of heat shock proteins |
| WP:WP4754 | 0.000586527811159 | 1.0 | CFLAR CASP8 | IL 18 signaling pathway |
| KEGG:05142 | 0.000622316790444 | 1.0 | CFLAR CASP8 | Chagas disease |
| KEGG:04668 | 0.000725873685824 | 1.0 | CFLAR CASP8 | TNF signaling pathway |
| WP:WP254 | 0.00111857408398 | 1.0 | CFLAR CASP8 | Apoptosis |
| KEGG:04210 | 0.00116074761854 | 1.0 | CFLAR CASP8 | Apoptosis |
| WP:WP1772 | 0.00127818796583 | 1.0 | CFLAR CASP8 | Apoptosis modulation and signaling |
| KEGG:05160 | 0.00138428094844 | 1.0 | CFLAR CASP8 | Hepatitis C |
| WP:WP231 | 0.00148377064565 | 1.0 | CFLAR CASP8 | TNF alpha signaling pathway |
| KEGG:04217 | 0.00151449927371 | 1.0 | CFLAR CASP8 | Necroptosis |
| GO:0097342 | 0.00468200720083 | 1.0 | CFLAR CASP8 | ripoptosome |
| GO:0031264 | 0.00983221512175 | 1.0 | CFLAR CASP8 | death-inducing signaling complex |
| REAC:R-HSA-73887 | 0.0136718027788 | 1.0 | CFLAR CASP8 | Death Receptor Signaling |
| GO:0097153 | 0.016855225923 | 1.0 | CFLAR CASP8 | cysteine-type endopeptidase activity involved in apoptotic process |
| CORUM:1062 | 0.0249718442457 | 0.5 | CASP8 | BAR-BCL2-CASP8 complex |
| CORUM:5991 | 0.0499419797295 | 0.5 | CASP8 | LRRK2-FADD-CASP8 complex |
| CORUM:5859 | 0.0499419797295 | 0.5 | CASP8 | FAS-FADD-CASP8-CASP10 complex |
| CORUM:5800 | 0.0499419797295 | 0.5 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5473 | 0.0499419797295 | 0.5 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5860 | 0.0499419797295 | 0.5 | CASP8 | DISC complex (FAS, FADD, CASP8) |
| CORUM:5808 | 0.0499419797295 | 0.5 | CASP8 | DISC complex (CD95, FADD, CASP8) |
| HP:0033278 | 0.0499436884913 | 0.5 | CASP8 | Reduced CD95-induced lymphocyte apoptosis |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CASP8 | CFLAR | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CASP8 | huMAP3_04434.1 huMAP3_09961.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_11605.1 huMAP3_13943.1 |
| CFLAR | huMAP3_04434.1 huMAP3_09961.1 huMAP3_10476.1 huMAP3_11149.1 huMAP3_13943.1 |