hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04437.1
Complex Portal: CPX-13007
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| DUSP9 | Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4) | 5 | UniProt NCBI |
| DUSP7 | Dual specificity protein phosphatase 7 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase PYST2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9652817 | 3.58839967947e-05 | 1.0 | DUSP9 DUSP7 | Signaling by MAPK mutants |
| REAC:R-HSA-112409 | 0.000292198259614 | 1.0 | DUSP9 DUSP7 | RAF-independent MAPK1/3 activation |
| REAC:R-HSA-5675221 | 0.00120125951175 | 1.0 | DUSP9 DUSP7 | Negative regulation of MAPK pathway |
| REAC:R-HSA-6802957 | 0.00424627295404 | 1.0 | DUSP9 DUSP7 | Oncogenic MAPK signaling |
| KEGG:04010 | 0.0047800367266 | 1.0 | DUSP9 DUSP7 | MAPK signaling pathway |
| WP:WP382 | 0.00855530406698 | 1.0 | DUSP9 DUSP7 | MAPK signaling pathway |
| GO:0008330 | 0.016855225923 | 1.0 | DUSP9 DUSP7 | protein tyrosine/threonine phosphatase activity |
| GO:0017017 | 0.016855225923 | 1.0 | DUSP9 DUSP7 | MAP kinase tyrosine/serine/threonine phosphatase activity |
| GO:0033550 | 0.016855225923 | 1.0 | DUSP9 DUSP7 | MAP kinase tyrosine phosphatase activity |
| GO:0033549 | 0.0309012475255 | 1.0 | DUSP9 DUSP7 | MAP kinase phosphatase activity |
| REAC:R-HSA-5673001 | 0.0385804228396 | 1.0 | DUSP9 DUSP7 | RAF/MAP kinase cascade |
| REAC:R-HSA-5684996 | 0.0400465404229 | 1.0 | DUSP9 DUSP7 | MAPK1/MAPK3 signaling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DUSP9 | DUSP7 | 0.993 | 0.054 |
mutually_exclusive (Q16539)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| DUSP9 | huMAP3_04437.1 huMAP3_06585.1 huMAP3_07439.1 huMAP3_14776.1 |
| DUSP7 | huMAP3_04437.1 huMAP3_14776.1 |