hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04439.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PON3 | Serum paraoxonase/lactonase 3 (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) | 5 | UniProt NCBI |
| PON1 | Serum paraoxonase/arylesterase 1 (PON 1) (EC 3.1.1.2) (EC 3.1.1.81) (EC 3.1.8.1) (Aromatic esterase 1) (A-esterase 1) (K-45) (Serum aryldialkylphosphatase 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP136 | 8.93837738341e-06 | 1.0 | PON3 PON1 | Phase I biotransformations non P450 |
| REAC:R-HSA-2142688 | 3.58839967947e-05 | 1.0 | PON3 PON1 | Synthesis of 5-eicosatetraenoic acids |
| REAC:R-HSA-9754706 | 4.78453290596e-05 | 1.0 | PON3 PON1 | Atorvastatin ADME |
| HP:0009067 | 0.00180445241025 | 1.0 | PON3 PON1 | Progressive spinal muscular atrophy |
| REAC:R-HSA-2142753 | 0.0019274832564 | 1.0 | PON3 PON1 | Arachidonic acid metabolism |
| HP:0008955 | 0.00203342648503 | 1.0 | PON3 PON1 | Progressive distal muscular atrophy |
| HP:0033683 | 0.00240251902349 | 1.0 | PON3 PON1 | Jaw hyperreflexia |
| HP:0025425 | 0.00240251902349 | 1.0 | PON3 PON1 | Laryngospasm |
| HP:0030195 | 0.00266566833332 | 1.0 | PON3 PON1 | Fatigable weakness of swallowing muscles |
| HP:0012473 | 0.00323297723503 | 1.0 | PON3 PON1 | Tongue atrophy |
| HP:0025424 | 0.00323297723503 | 1.0 | PON3 PON1 | Abnormal larynx physiology |
| HP:0007354 | 0.00353713682691 | 1.0 | PON3 PON1 | Amyotrophic lateral sclerosis |
| HP:0002145 | 0.0038549665128 | 1.0 | PON3 PON1 | Frontotemporal dementia |
| HP:0007269 | 0.00418646629272 | 1.0 | PON3 PON1 | Spinal muscular atrophy |
| HP:0000217 | 0.00418646629272 | 1.0 | PON3 PON1 | Xerostomia |
| HP:0030196 | 0.00470934738887 | 1.0 | PON3 PON1 | Fatigable weakness of respiratory muscles |
| HP:0030192 | 0.0054543675128 | 1.0 | PON3 PON1 | Fatigable weakness of bulbar muscles |
| REAC:R-HSA-9748784 | 0.0055363880769 | 1.0 | PON3 PON1 | Drug ADME |
| HP:0007373 | 0.00604901660254 | 1.0 | PON3 PON1 | Motor neuron atrophy |
| GO:0004064 | 0.00702301080125 | 1.0 | PON3 PON1 | arylesterase activity |
| HP:0002450 | 0.00849254590808 | 1.0 | PON3 PON1 | Abnormal motor neuron morphology |
| HP:0002180 | 0.009230730985 | 1.0 | PON3 PON1 | Neurodegeneration |
| HP:0012757 | 0.00973994198714 | 1.0 | PON3 PON1 | Abnormal neuron morphology |
| HP:0004326 | 0.0122005589102 | 1.0 | PON3 PON1 | Cachexia |
| HP:0000713 | 0.0159119894358 | 1.0 | PON3 PON1 | Agitation |
| REAC:R-HSA-8978868 | 0.0180872431463 | 1.0 | PON3 PON1 | Fatty acid metabolism |
| HP:0003473 | 0.0193807757926 | 1.0 | PON3 PON1 | Fatigable weakness |
| HP:0012535 | 0.0197464508076 | 1.0 | PON3 PON1 | Abnormal synaptic transmission |
| HP:0030191 | 0.0197464508076 | 1.0 | PON3 PON1 | Abnormal peripheral nervous system synaptic transmission |
| HP:0003398 | 0.0197464508076 | 1.0 | PON3 PON1 | Abnormal synaptic transmission at the neuromuscular junction |
| HP:0003324 | 0.0224018665704 | 1.0 | PON3 PON1 | Generalized muscle weakness |
| HP:0002380 | 0.0224018665704 | 1.0 | PON3 PON1 | Fasciculations |
| HP:0009027 | 0.0244011178204 | 1.0 | PON3 PON1 | Foot dorsiflexor weakness |
| HP:0003484 | 0.0282150740512 | 1.0 | PON3 PON1 | Upper limb muscle weakness |
| HP:0000711 | 0.0286559345832 | 1.0 | PON3 PON1 | Restlessness |
| HP:0003470 | 0.0318376489657 | 1.0 | PON3 PON1 | Paralysis |
| HP:0003394 | 0.0361744862926 | 1.0 | PON3 PON1 | Muscle spasm |
| HP:0000712 | 0.0387034536857 | 1.0 | PON3 PON1 | Emotional lability |
| HP:0100755 | 0.0496737041344 | 1.0 | PON3 PON1 | Abnormality of salivation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| PON3 | PON1 | 1.0 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes
| Genename | Complexes |
|---|---|
| PON3 | huMAP3_04439.1 huMAP3_10252.1 huMAP3_10510.1 huMAP3_10872.1 huMAP3_12192.1 huMAP3_14322.1 huMAP3_15003.1 |
| PON1 | huMAP3_04439.1 huMAP3_10252.1 huMAP3_10510.1 huMAP3_14322.1 |