hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04468.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CDK5 | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | 5 | UniProt NCBI |
| CNPPD1 | Protein CNPPD1 (Cyclin Pas1/PHO80 domain-containing protein 1) | 3 | UniProt NCBI |
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | 5 | UniProt NCBI |
| CCNI | Cyclin-I | 4 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000307 | 8.97405436883e-06 | 1.0 | CNPPD1 CCNI CDK5 CDK5R1 | cyclin-dependent protein kinase holoenzyme complex |
| REAC:R-HSA-9032845 | 0.000102497642323 | 0.5 | CDK5R1 CDK5 | Activated NTRK2 signals through CDK5 |
| GO:1902554 | 0.00026336641285 | 1.0 | CNPPD1 CCNI CDK5 CDK5R1 | serine/threonine protein kinase complex |
| GO:1902911 | 0.000439465274636 | 1.0 | CNPPD1 CCNI CDK5 CDK5R1 | protein kinase complex |
| REAC:R-HSA-399956 | 0.00107524337392 | 0.5 | CDK5R1 CDK5 | CRMPs in Sema3A signaling |
| REAC:R-HSA-9006115 | 0.00156635412759 | 0.5 | CDK5R1 CDK5 | Signaling by NTRK2 (TRKB) |
| REAC:R-HSA-9768919 | 0.00156635412759 | 0.5 | CDK5R1 CDK5 | NPAS4 regulates expression of target genes |
| KEGG:05030 | 0.00204942716049 | 0.5 | CDK5R1 CDK5 | Cocaine addiction |
| WP:WP3878 | 0.0020866894725 | 0.5 | CDK5R1 CDK5 | ATM signaling in development and disease |
| REAC:R-HSA-8862803 | 0.00214930898727 | 0.5 | CDK5R1 CDK5 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00214930898727 | 0.5 | CDK5R1 CDK5 | Neurodegenerative Diseases |
| GO:0016533 | 0.0028092043205 | 0.5 | CDK5R1 CDK5 | protein kinase 5 complex |
| REAC:R-HSA-9734009 | 0.00282403231951 | 0.5 | CDK5R1 CDK5 | Defective Intrinsic Pathway for Apoptosis |
| REAC:R-HSA-9634815 | 0.00386628370571 | 0.5 | CDK5R1 CDK5 | Transcriptional Regulation by NPAS4 |
| GO:0016538 | 0.00440499676786 | 0.75 | CNPPD1 CCNI CDK5R1 | cyclin-dependent protein serine/threonine kinase regulator activity |
| REAC:R-HSA-9031628 | 0.00507136546841 | 0.5 | CDK5R1 CDK5 | NGF-stimulated transcription |
| GO:0061695 | 0.00622455085576 | 1.0 | CNPPD1 CCNI CDK5 CDK5R1 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-198725 | 0.0146019089592 | 0.5 | CDK5R1 CDK5 | Nuclear Events (kinase and transcription factor activation) |
| REAC:R-HSA-373755 | 0.0174510452107 | 0.5 | CDK5R1 CDK5 | Semaphorin interactions |
| WP:WP2380 | 0.01895043011 | 0.5 | CDK5R1 CDK5 | Brain derived neurotrophic factor BDNF signaling pathway |
| REAC:R-HSA-6804756 | 0.0398310607487 | 0.5 | CDK5R1 CDK5 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-9645723 | 0.041644107744 | 0.5 | CDK5R1 CDK5 | Diseases of programmed cell death |
| REAC:R-HSA-187037 | 0.0473231872721 | 0.5 | CDK5R1 CDK5 | Signaling by NTRK1 (TRKA) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CDK5 | CDK5R1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CDK5 | CCNI | 0.993 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CNPPD1 | CDK5 | 0.992 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
Related Complexes