hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04482.1
Complex Portal: CPX-24737
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SFT2D2 | Vesicle transport protein SFT2B (SFT2 domain-containing protein 2) | 5 | UniProt NCBI |
| XCL1 | Lymphotactin (ATAC) (C motif chemokine 1) (Cytokine SCM-1) (Lymphotaxin) (SCM-1-alpha) (Small-inducible cytokine C1) (XC chemokine ligand 1) | 5 | UniProt NCBI |
| HOMER2 | Homer protein homolog 2 (Homer-2) (Cupidin) | 5 | UniProt NCBI |
| HOMER3 | Homer protein homolog 3 (Homer-3) | 5 | UniProt NCBI |
| SPOPL | Speckle-type POZ protein-like (HIB homolog 2) (Roadkill homolog 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0032703 | 0.000783132248318 | 0.6 | XCL1 HOMER2 HOMER3 | negative regulation of interleukin-2 production |
| GO:0032623 | 0.00875197805683 | 0.6 | XCL1 HOMER2 HOMER3 | interleukin-2 production |
| GO:0032663 | 0.00875197805683 | 0.6 | XCL1 HOMER2 HOMER3 | regulation of interleukin-2 production |
| KEGG:04724 | 0.0145692619713 | 0.4 | HOMER2 HOMER3 | Glutamatergic synapse |
| REAC:R-HSA-6794361 | 0.0156388304105 | 0.4 | HOMER2 HOMER3 | Neurexins and neuroligins |
| WP:WP5417 | 0.0212523049113 | 0.4 | HOMER2 HOMER3 | Cell lineage map for neuronal differentiation |
| KEGG:04068 | 0.028330266578 | 0.4 | HOMER2 HOMER3 | FoxO signaling pathway |
| REAC:R-HSA-6794362 | 0.0363707033179 | 0.4 | HOMER2 HOMER3 | Protein-protein interactions at synapses |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| HOMER3 | HOMER2 | 0.998 |
mutually_exclusive (Q6IQ16)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SPOPL | HOMER3 | 0.993 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| XCL1 | SPOPL | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SFT2D2 | SPOPL | 0.989 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| SPOPL | HOMER2 | 0.956 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SFT2D2 | XCL1 | 0.415 | bioplex3_WMM WMM_only | ||
| SFT2D2 | HOMER3 | 0.415 | 0.02 | bioplex3_WMM WMM_only | |
| SFT2D2 | HOMER2 | 0.278 | bioplex3_WMM WMM_only | ||
| XCL1 | HOMER3 | 0.25 | bioplex3_WMM WMM_only | ||
| XCL1 | HOMER2 | 0.113 | bioplex3_WMM WMM_only |
Related Complexes