hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04493.1
Complex Portal: CPX-21254
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| MAFK | Transcription factor MafK (Erythroid transcription factor NF-E2 p18 subunit) | 5 | UniProt NCBI |
| MAFF | Transcription factor MafF (U-Maf) (V-maf musculoaponeurotic fibrosarcoma oncogene homolog F) | 5 | UniProt NCBI |
| NFE2L3 | Nuclear factor erythroid 2-related factor 3 (NF-E2-related factor 3) (NFE2-related factor 3) (Nuclear factor, erythroid derived 2, like 3) | 5 | UniProt NCBI |
| NFE2L1 | Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)] | 5 | UniProt NCBI |
| MAFG | Transcription factor MafG (V-maf musculoaponeurotic fibrosarcoma oncogene homolog G) (hMAF) | 5 | UniProt NCBI |
| BACH2 | Transcription regulator protein BACH2 (BTB and CNC homolog 2) | 5 | UniProt NCBI |
| NFE2L2 | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4269 | 1.16709414068e-10 | 0.571428571429 | MAFK NFE2L2 MAFF MAFG | Ethanol metabolism production of ROS by CYP2E1 |
| WP:WP2435 | 2.21341667542e-06 | 0.428571428571 | MAFK MAFG NFE2L2 | Quercetin and Nf kB AP 1 induced apoptosis |
| GO:0090575 | 2.44950226668e-06 | 0.857142857143 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK | RNA polymerase II transcription regulator complex |
| GO:0000978 | 5.1961835834e-05 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO:0000987 | 6.01089924876e-05 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | cis-regulatory region sequence-specific DNA binding |
| GO:0005667 | 7.22701511969e-05 | 0.857142857143 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK | transcription regulator complex |
| GO:0000981 | 0.000133696937271 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.000162986217933 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| GO:0003700 | 0.000206801389084 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | DNA-binding transcription factor activity |
| GO:0000976 | 0.000296581958573 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | transcription cis-regulatory region binding |
| GO:0001067 | 0.000298715641728 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | transcription regulatory region nucleic acid binding |
| REAC:R-HSA-9707587 | 0.000380832872101 | 0.285714285714 | MAFK NFE2L2 | Regulation of HMOX1 expression and activity |
| GO:1990837 | 0.000412217110012 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | sequence-specific double-stranded DNA binding |
| GO:0043565 | 0.000680739891253 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | sequence-specific DNA binding |
| GO:0003690 | 0.00069385471361 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | double-stranded DNA binding |
| REAC:R-HSA-9759194 | 0.000976813602208 | 0.428571428571 | MAFK MAFG NFE2L2 | Nuclear events mediated by NFE2L2 |
| REAC:R-HSA-9818028 | 0.00106560242715 | 0.285714285714 | NFE2L2 MAFG | NFE2L2 regulates pentose phosphate pathway genes |
| WP:WP2884 | 0.00135826261108 | 0.428571428571 | NFE2L2 MAFF MAFG | NRF2 pathway |
| REAC:R-HSA-9755511 | 0.0023257157346 | 0.428571428571 | MAFK MAFG NFE2L2 | KEAP1-NFE2L2 pathway |
| GO:0140110 | 0.00271308272393 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | transcription regulator activity |
| REAC:R-HSA-9818027 | 0.00455853850403 | 0.285714285714 | MAFK NFE2L2 | NFE2L2 regulating anti-oxidant/detoxification enzymes |
| GO:0003677 | 0.00595089615939 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | DNA binding |
| REAC:R-HSA-983231 | 0.00799265153172 | 0.428571428571 | MAFK MAFF MAFG | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-9711123 | 0.0126241322329 | 0.428571428571 | MAFK MAFG NFE2L2 | Cellular response to chemical stress |
| WP:WP2882 | 0.0150791515196 | 0.428571428571 | NFE2L2 MAFF MAFG | Nuclear receptors meta pathway |
| GO:0006357 | 0.0154035672085 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | regulation of transcription by RNA polymerase II |
| GO:0006366 | 0.0223743566348 | 1.0 | NFE2L2 BACH2 MAFF NFE2L3 MAFG MAFK NFE2L1 | transcription by RNA polymerase II |
| GO:0000785 | 0.0281620326922 | 0.857142857143 | NFE2L2 BACH2 MAFF NFE2L3 NFE2L1 MAFK | chromatin |
| REAC:R-HSA-9707616 | 0.0325139680435 | 0.285714285714 | MAFK NFE2L2 | Heme signaling |
| GO:0032993 | 0.0399950924513 | 0.857142857143 | NFE2L2 BACH2 MAFF NFE2L3 NFE2L1 MAFK | protein-DNA complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| MAFF | NFE2L2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAFF | BACH2 | 0.999 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NFE2L3 | MAFF | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| MAFF | NFE2L1 | 0.998 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NFE2L3 | MAFK | 0.994 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| NFE2L3 | MAFG | 0.991 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | ||
| MAFK | MAFF | 0.985 | 0.206 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| MAFK | MAFG | 0.974 | 0.248 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| MAFK | BACH2 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| MAFF | MAFG | 0.956 | 0.208 |
structurally_consistent (dimer)
|
hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| MAFK | NFE2L2 | 0.955 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NFE2L3 | NFE2L2 | 0.947 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L1 | NFE2L2 | 0.939 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFG | BACH2 | 0.913 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| NFE2L3 | NFE2L1 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only | ||
| BACH2 | NFE2L2 | 0.908 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L1 | BACH2 | 0.904 | bioplex_WMM bioplex3_WMM WMM_only | ||
| NFE2L3 | BACH2 | 0.884 | bioplex_WMM bioplex3_WMM WMM_only | ||
| MAFK | NFE2L1 | 0.772 |
mutually_exclusive (Q9ULX9)
|
bioplex3_HEK293 bioplex3_WMM WMM_only | |
| MAFG | NFE2L2 | 0.21 | bioplex3_WMM WMM_only | ||
| NFE2L1 | MAFG | 0.076 | bioplex3_WMM WMM_only |
Related Complexes