hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04495.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SELENOS | Selenoprotein S (SelS) (VCP-interacting membrane protein) | 5 | UniProt NCBI |
| FZD1 | Frizzled-1 (Fz-1) (hFz1) (FzE1) | 5 | UniProt NCBI |
| SCN8A | Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) | 5 | UniProt NCBI |
| FZD5 | Frizzled-5 (Fz-5) (hFz5) (FzE5) | 5 | UniProt NCBI |
| SCN7A | Sodium channel protein type 7 subunit alpha (Atypical sodium channel Nav2.1) (Nax channel) (Sodium channel protein type VII subunit alpha) | 5 | UniProt NCBI |
| SCN4A | Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) | 5 | UniProt NCBI |
| XIRP1 | Xin actin-binding repeat-containing protein 1 (Cardiomyopathy-associated protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-445095 | 2.29983491089e-05 | 0.428571428571 | SCN7A SCN8A SCN4A | Interaction between L1 and Ankyrins |
| REAC:R-HSA-5576892 | 2.62784267685e-05 | 0.428571428571 | SCN7A SCN8A SCN4A | Phase 0 - rapid depolarisation |
| GO:0008331 | 0.00122180600483 | 0.428571428571 | SCN7A SCN8A SCN4A | high voltage-gated calcium channel activity |
| REAC:R-HSA-5576891 | 0.00126637654584 | 0.428571428571 | SCN7A SCN8A SCN4A | Cardiac conduction |
| GO:0005248 | 0.00152694380207 | 0.428571428571 | SCN7A SCN8A SCN4A | voltage-gated sodium channel activity |
| REAC:R-HSA-373760 | 0.00219374690011 | 0.428571428571 | SCN7A SCN8A SCN4A | L1CAM interactions |
| GO:0098703 | 0.00677983410628 | 0.428571428571 | SCN7A SCN8A SCN4A | calcium ion import across plasma membrane |
| GO:1902656 | 0.00677983410628 | 0.428571428571 | SCN7A SCN8A SCN4A | calcium ion import into cytosol |
| REAC:R-HSA-397014 | 0.00697432613022 | 0.428571428571 | SCN7A SCN8A SCN4A | Muscle contraction |
| GO:0005272 | 0.00979189312029 | 0.428571428571 | SCN7A SCN8A SCN4A | sodium channel activity |
| WP:WP4150 | 0.00991981492579 | 0.285714285714 | FZD1 FZD5 | Wnt signaling in kidney disease |
| GO:0005245 | 0.0150353457168 | 0.428571428571 | SCN7A SCN8A SCN4A | voltage-gated calcium channel activity |
| KEGG:05217 | 0.0150576821029 | 0.285714285714 | FZD1 FZD5 | Basal cell carcinoma |
| WP:WP5420 | 0.0169268600769 | 0.428571428571 | SCN7A SCN8A SCN4A | ADHD and autism ASD linked metabolic pathways and SNP |
| REAC:R-HSA-4641262 | 0.0176039638163 | 0.285714285714 | FZD1 FZD5 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| GO:0005891 | 0.0182422971773 | 0.428571428571 | SCN7A SCN8A SCN4A | voltage-gated calcium channel complex |
| WP:WP3680 | 0.0300823189809 | 0.285714285714 | FZD1 FZD5 | Physico chemical features and toxicity associated pathways |
| KEGG:04916 | 0.0342858776489 | 0.285714285714 | FZD1 FZD5 | Melanogenesis |
| WP:WP4336 | 0.0473257570206 | 0.285714285714 | FZD1 FZD5 | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| GO:0070509 | 0.0473277551461 | 0.428571428571 | SCN7A SCN8A SCN4A | calcium ion import |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SCN8A | SCN4A | 0.99 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD5 | SCN4A | 0.988 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| SCN7A | SCN4A | 0.986 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| FZD1 | SCN4A | 0.985 | bioplex3_HEK293 bioplex3_WMM WMM_only | |
| XIRP1 | SCN4A | 0.964 | 0.05 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| SELENOS | SCN4A | 0.951 | 0.084 | bioplex3_HEK293 bioplex3_WMM WMM_only |
| FZD5 | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| FZD5 | SCN8A | 0.415 | bioplex3_WMM WMM_only | |
| SCN8A | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| FZD5 | FZD1 | 0.415 | bioplex3_WMM WMM_only | |
| XIRP1 | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| XIRP1 | FZD1 | 0.415 | bioplex3_WMM WMM_only | |
| FZD1 | SCN7A | 0.415 | bioplex3_WMM WMM_only | |
| XIRP1 | SCN8A | 0.415 | bioplex3_WMM WMM_only | |
| FZD1 | SCN8A | 0.415 | bioplex3_WMM WMM_only | |
| SELENOS | SCN8A | 0.274 | bioplex3_WMM WMM_only | |
| FZD5 | XIRP1 | 0.274 | bioplex3_WMM WMM_only | |
| SELENOS | SCN7A | 0.274 | bioplex3_WMM WMM_only | |
| SELENOS | FZD1 | 0.113 | bioplex3_WMM WMM_only | |
| FZD5 | SELENOS | 0.078 | bioplex3_WMM WMM_only | |
| XIRP1 | SELENOS | 0.076 | 0.004 | bioplex3_WMM WMM_only |
Related Complexes