hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04537.1

Complex Portal: CPX-10863

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
SMTNL2	Smoothelin-like protein 2	3	UniProt NCBI
TIAM1	Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)	5	UniProt NCBI
DENND4A	C-myc promoter-binding protein (DENN domain-containing protein 4A)	5	UniProt NCBI
PACS2	Phosphofurin acidic cluster sorting protein 2 (PACS-2) (PACS1-like protein)	5	UniProt NCBI
SAMD4A	Protein Smaug homolog 1 (Smaug 1) (hSmaug1) (Sterile alpha motif domain-containing protein 4A) (SAM domain-containing protein 4A)	5	UniProt NCBI
SRGAP1	SLIT-ROBO Rho GTPase-activating protein 1 (srGAP1) (Rho GTPase-activating protein 13)	5	UniProt NCBI
TFEB	Transcription factor EB (Class E basic helix-loop-helix protein 35) (bHLHe35)	5	UniProt NCBI
CDC25B	M-phase inducer phosphatase 2 (EC 3.1.3.48) (Dual specificity phosphatase Cdc25B)	5	UniProt NCBI
IRS2	Insulin receptor substrate 2 (IRS-2)	5	UniProt NCBI
SPATA13	Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)	5	UniProt NCBI
SPIRE2	Protein spire homolog 2 (Spir-2)	5	UniProt NCBI
SASH1	SAM and SH3 domain-containing protein 1 (Proline-glutamate repeat-containing protein)	5	UniProt NCBI
FOXO3	Forkhead box protein O3 (AF6q21 protein) (Forkhead in rhabdomyosarcoma-like 1)	5	UniProt NCBI
SYDE2	Rho GTPase-activating protein SYDE2 (Synapse defective protein 1 homolog 2) (Protein syd-1 homolog 2)	4	UniProt NCBI
PTOV1	Prostate tumor-overexpressed gene 1 protein (PTOV-1) (Activator interaction domain-containing protein 2)	5	UniProt NCBI
LNP1	Leukemia NUP98 fusion partner 1	2	UniProt NCBI
BRAF	Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)	5	UniProt NCBI
PTPN3	Tyrosine-protein phosphatase non-receptor type 3 (EC 3.1.3.48) (Protein-tyrosine phosphatase H1) (PTP-H1)	5	UniProt NCBI
KIAA0930	Uncharacterized protein KIAA0930	3	UniProt NCBI
PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (6PF-2-K/Fru-2,6-P2ase 2) (PFK/FBPase 2) (6PF-2-K/Fru-2,6-P2ase heart-type isozyme) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]	5	UniProt NCBI
SPIRE1	Protein spire homolog 1 (Spir-1)	5	UniProt NCBI
FAM53B	Protein FAM53B (Protein simplet)	5	UniProt NCBI
BAD	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	5	UniProt NCBI
YWHAH	14-3-3 protein eta (Protein AS1)	5	UniProt NCBI
HDAC5	Histone deacetylase 5 (HD5) (EC 3.5.1.98) (Antigen NY-CO-9)	5	UniProt NCBI
FOXO1	Forkhead box protein O1 (Forkhead box protein O1A) (Forkhead in rhabdomyosarcoma)	5	UniProt NCBI
HDAC4	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	5	UniProt NCBI
FOXO4	Forkhead box protein O4 (Fork head domain transcription factor AFX1)	5	UniProt NCBI
SRGAP2	SLIT-ROBO Rho GTPase-activating protein 2 (srGAP2) (Formin-binding protein 2) (Rho GTPase-activating protein 34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
WP:WP3844	2.14359276278e-05	0.16	FOXO3 BAD FOXO4 FOXO1	PI3K AKT mTOR signaling pathway and therapeutic opportunities in prostate cancer
REAC:R-HSA-5674400	2.66889247087e-05	0.16	FOXO3 BAD FOXO4 FOXO1	Constitutive Signaling by AKT1 E17K in Cancer
REAC:R-HSA-2219528	5.29208348575e-05	0.2	IRS2 FOXO1 BAD FOXO4 FOXO3	PI3K/AKT Signaling in Cancer
REAC:R-HSA-9617629	0.00017091009608	0.12	FOXO3 FOXO1 FOXO4	Regulation of FOXO transcriptional activity by acetylation
REAC:R-HSA-198693	0.00017091009608	0.12	FOXO3 FOXO1 FOXO4	AKT phosphorylates targets in the nucleus
REAC:R-HSA-9614399	0.000312628043924	0.12	FOXO3 FOXO1 FOXO4	Regulation of localization of FOXO transcription factors
REAC:R-HSA-1257604	0.000637072848382	0.24	FOXO3 IRS2 FOXO1 FOXO4 HDAC5 BAD	PIP3 activates AKT signaling
REAC:R-HSA-5663202	0.000675094158516	0.28	FOXO3 IRS2 FOXO1 FOXO4 HDAC5 BAD HDAC4	Diseases of signal transduction by growth factor receptors and second messengers
REAC:R-HSA-9617828	0.000792192931755	0.12	FOXO3 FOXO1 FOXO4	FOXO-mediated transcription of cell cycle genes
REAC:R-HSA-9614657	0.000792192931755	0.12	FOXO3 FOXO1 FOXO4	FOXO-mediated transcription of cell death genes
REAC:R-HSA-9006925	0.00144541752441	0.24	FOXO3 IRS2 FOXO1 FOXO4 HDAC5 BAD	Intracellular signaling by second messengers
WP:WP4542	0.0018993533488	0.12	FOXO3 FOXO1 FOXO4	Leukocyte intrinsic Hippo pathway functions
REAC:R-HSA-9013149	0.00200740406528	0.2	SRGAP2 SYDE2 SPATA13 TIAM1 SRGAP1	RAC1 GTPase cycle
REAC:R-HSA-162582	0.00219458554591	0.52	FOXO3 SPATA13 IRS2 TIAM1 FOXO4 SRGAP1 BAD YWHAH HDAC4 HDAC5 SRGAP2 FOXO1 SYDE2	Signal Transduction
KEGG:04068	0.00244246628522	0.16	IRS2 FOXO1 FOXO4 FOXO3	FoxO signaling pathway
KEGG:04152	0.00244246628522	0.16	IRS2 PFKFB2 FOXO1 FOXO3	AMPK signaling pathway
REAC:R-HSA-9615017	0.0032207437013	0.12	FOXO3 FOXO1 FOXO4	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
WP:WP3888	0.00431289417353	0.24	FOXO3 SPIRE1 FOXO1 FOXO4 HDAC5 HDAC4	VEGFA VEGFR2 signaling
WP:WP2380	0.0063802534344	0.16	BAD IRS2 TIAM1 FOXO3	Brain derived neurotrophic factor BDNF signaling pathway
WP:WP3932	0.00658381116681	0.2	IRS2 PFKFB2 FOXO1 BAD FOXO3	Focal adhesion PI3K Akt mTOR signaling pathway
KEGG:04213	0.00668822390624	0.12	IRS2 FOXO1 FOXO3	Longevity regulating pathway - multiple species
WP:WP3630	0.0151764181003	0.08	FOXO3 FOXO1	NAD metabolism sirtuins and aging
KEGG:05203	0.0168366444788	0.16	YWHAH HDAC4 BAD HDAC5	Viral carcinogenesis
TF:M00800_1	0.0178426206447	0.72	SRGAP2 FOXO3 IRS2 SYDE2 FAM53B DENND4A BAD SRGAP1 PTOV1 YWHAH PACS2 HDAC5 SPIRE2 HDAC4 SASH1 FOXO1 SPIRE1 SAMD4A	Factor: AP-2; motif: GSCCSCRGGCNRNRNN; match class: 1
REAC:R-HSA-9013148	0.0187993440302	0.16	SRGAP2 SPATA13 TIAM1 SRGAP1	CDC42 GTPase cycle
KEGG:04211	0.0223156640637	0.12	IRS2 FOXO1 FOXO3	Longevity regulating pathway
WP:WP4746	0.0249284522132	0.12	PFKFB2 BAD FOXO1	Thyroid hormones production and peripheral downstream signaling effects
REAC:R-HSA-428543	0.0253778916789	0.08	SRGAP2 SRGAP1	Inactivation of CDC42 and RAC1
WP:WP2261	0.0360183411834	0.12	FOXO3 FOXO1 FOXO4	Glioblastoma signaling pathways
REAC:R-HSA-9614085	0.0460626160414	0.12	FOXO3 FOXO1 FOXO4	FOXO-mediated transcription
KEGG:04919	0.0477215402924	0.12	PFKFB2 BAD FOXO1	Thyroid hormone signaling pathway

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap
YWHAH	SAMD4A	0.999	0.412630536131
YWHAH	FAM53B	0.999
SMTNL2	YWHAH	0.997
HDAC4	YWHAH	0.997	0.39
YWHAH	IRS2	0.996	0.44925
YWHAH	TFEB	0.995	0.340814070352
YWHAH	BRAF	0.993	0.382
CDC25B	YWHAH	0.99	0.33
HDAC4	PTOV1	0.989	0.13
FOXO3	YWHAH	0.988	0.24
IRS2	BRAF	0.987	0.11
SRGAP2	YWHAH	0.986	0.166
PFKFB2	YWHAH	0.985	0.332	mutually_exclusive (P27348)
YWHAH	LNP1	0.984
PACS2	YWHAH	0.983	0.331910666153
IRS2	PTOV1	0.983	0.098
YWHAH	BAD	0.982	0.142
HDAC4	IRS2	0.981	0.140666666667
YWHAH	KIAA0930	0.981	0.246666666667
SRGAP1	SRGAP2	0.98	0.202
SRGAP1	YWHAH	0.976	0.351043478261
YWHAH	SPIRE1	0.975	0.222660377358
YWHAH	DENND4A	0.975	0.28	mutually_exclusive (P27348)
SASH1	YWHAH	0.974	0.292
YWHAH	FOXO1	0.973	0.432967741935	mutually_exclusive (P27348)
YWHAH	TIAM1	0.971	0.236
YWHAH	SPATA13	0.971	0.252554778555
YWHAH	PTOV1	0.97	0.388998934375
YWHAH	PTPN3	0.969	0.319
SYDE2	YWHAH	0.965
SPIRE2	YWHAH	0.964
YWHAH	HDAC5	0.961	0.290709677419
YWHAH	FOXO4	0.954		mutually_exclusive (P31947)
SPIRE2	BRAF	0.898
SPIRE2	IRS2	0.838
SPIRE2	SPIRE1	0.781
TFEB	IRS2	0.617	0.168
CDC25B	TFEB	0.605	0.112
PFKFB2	SPIRE1	0.605	0.042
CDC25B	FAM53B	0.605
TFEB	BAD	0.605	0.08
CDC25B	FOXO3	0.605	0.138
TFEB	FOXO1	0.576	0.15
FOXO3	TFEB	0.566	0.046
DENND4A	IRS2	0.566	0.08
IRS2	FOXO1	0.564	0.09
FOXO3	BAD	0.561	0.132
FAM53B	BAD	0.561
HDAC4	TIAM1	0.54	0.218
HDAC4	FOXO3	0.54	0.168
CDC25B	SPIRE1	0.54	0.132
HDAC4	FAM53B	0.54
HDAC4	TFEB	0.54	0.094
HDAC4	HDAC5	0.54	0.158
SRGAP2	CDC25B	0.539	0.0884395604396	mutually_exclusive (P27348)
SASH1	IRS2	0.539	0.1
SASH1	FOXO3	0.539	0.126
PFKFB2	SASH1	0.539	0.066	mutually_exclusive (P27348)
SASH1	SPIRE1	0.539	0.142
SASH1	FAM53B	0.539
SASH1	BAD	0.539	0.048	mutually_exclusive (P27348)
SASH1	HDAC5	0.539	0.132
SASH1	FOXO1	0.539	0.202	mutually_exclusive (P27348)
HDAC4	SASH1	0.539	0.09
PFKFB2	KIAA0930	0.539	0.092	mutually_exclusive (P27348)
SPIRE2	SASH1	0.539
PFKFB2	CDC25B	0.539	0.054	mutually_exclusive (P27348)
PFKFB2	BAD	0.539	0.068	mutually_exclusive (P27348)
KIAA0930	FAM53B	0.539
KIAA0930	SPIRE1	0.539	0.05
KIAA0930	BAD	0.539	0.064
SASH1	TFEB	0.539	0.092
SRGAP2	PFKFB2	0.539	0.038	mutually_exclusive (P27348)
SPIRE1	BAD	0.539	0.124
TFEB	BRAF	0.539	0.118
SRGAP2	SPIRE1	0.539	0.084
CDC25B	SASH1	0.539	0.07	mutually_exclusive (P27348)
TFEB	KIAA0930	0.539	0.09
FOXO3	KIAA0930	0.539	0.08
PFKFB2	DENND4A	0.539	0.028	mutually_exclusive (P27348)
CDC25B	BAD	0.539	0.126	mutually_exclusive (P27348)
SASH1	TIAM1	0.539	0.22
SASH1	SAMD4A	0.539	0.086
CDC25B	KIAA0930	0.539	0.128	mutually_exclusive (P27348)
SRGAP2	BAD	0.539	0.1	mutually_exclusive (P27348)
CDC25B	DENND4A	0.539	0.108
HDAC4	CDC25B	0.534	0.104
TIAM1	SPIRE1	0.534	0.202
IRS2	KIAA0930	0.534	0.134
PFKFB2	IRS2	0.534	0.076
IRS2	SPIRE1	0.534	0.08
IRS2	FAM53B	0.534
IRS2	BAD	0.534	0.098
TIAM1	HDAC5	0.534	0.102
TIAM1	FAM53B	0.534
PFKFB2	FOXO3	0.534	0.076
TIAM1	BAD	0.534	0.126
HDAC4	KIAA0930	0.534	0.078
PFKFB2	FAM53B	0.534
HDAC4	PFKFB2	0.534	0.046	mutually_exclusive (P27348)
SPIRE1	FAM53B	0.534
HDAC4	SPIRE1	0.534	0.204
SRGAP2	HDAC4	0.534	0.128
TFEB	SPIRE1	0.534	0.106
TFEB	FAM53B	0.534
HDAC4	DENND4A	0.534	0.082
PFKFB2	TIAM1	0.534	0.124
FOXO3	TIAM1	0.534	0.218
PFKFB2	TFEB	0.534	0.108
TIAM1	KIAA0930	0.534	0.04
TIAM1	IRS2	0.534	0.168
TIAM1	DENND4A	0.534	0.155
CDC25B	IRS2	0.534	0.118
HDAC4	BAD	0.534	0.08
CDC25B	TIAM1	0.534	0.162
SRGAP2	TIAM1	0.534	0.246
TFEB	TIAM1	0.534	0.076
CDC25B	HDAC5	0.534	0.088
SRGAP2	FOXO1	0.528	0.218133333333	mutually_exclusive (P27348)
SRGAP2	FAM53B	0.516
DENND4A	FAM53B	0.516
SRGAP2	IRS2	0.513	0.216
IRS2	PTPN3	0.504	0.126
TIAM1	FOXO1	0.496	0.16
HDAC4	FOXO1	0.496	0.168
TFEB	DENND4A	0.495	0.126
BRAF	SPIRE1	0.494	0.076
PFKFB2	BRAF	0.494	0.084	mutually_exclusive (P27348)
CDC25B	BRAF	0.494	0.106	mutually_exclusive (P27348)
TIAM1	BRAF	0.494	0.126
BRAF	BAD	0.494	0.134	mutually_exclusive (P27348)
FOXO3	IRS2	0.491	0.09
TFEB	HDAC5	0.491	0.114
FOXO3	SPIRE1	0.489	0.178
HDAC4	BRAF	0.489	0.0952
KIAA0930	FOXO1	0.489	0.102	mutually_exclusive (P27348)
PFKFB2	HDAC5	0.489	0.062
PFKFB2	FOXO1	0.489	0.102	mutually_exclusive (P27348)
SPIRE1	HDAC5	0.489	0.17
SPIRE1	FOXO1	0.489	0.158
BAD	HDAC5	0.489	0.104	mutually_exclusive (P31947)
BAD	FOXO1	0.489	0.09	mutually_exclusive (P27348)
CDC25B	FOXO1	0.489	0.162	mutually_exclusive (P27348)
SPIRE2	BAD	0.48
FOXO3	SAMD4A	0.48	0.128
HDAC4	SPIRE2	0.48
SASH1	BRAF	0.48	0.062	mutually_exclusive (P27348)
SASH1	KIAA0930	0.48	0.066	mutually_exclusive (P27348)
SPIRE2	TIAM1	0.48
SRGAP2	SASH1	0.48	0.104	mutually_exclusive (P27348)
PFKFB2	SPIRE2	0.48
SAMD4A	HDAC5	0.48	0.138
SAMD4A	FOXO1	0.48	0.154
HDAC4	SAMD4A	0.48	0.124
SAMD4A	BRAF	0.48	0.08
SPIRE2	TFEB	0.48
SPIRE2	CDC25B	0.48
SRGAP2	KIAA0930	0.48	0.074	mutually_exclusive (P27348)
SASH1	DENND4A	0.48	0.076
SPIRE2	SAMD4A	0.48
SPIRE2	KIAA0930	0.48
DENND4A	KIAA0930	0.48	0.142
DENND4A	SPIRE1	0.48	0.132
SAMD4A	SPIRE1	0.48	0.148
DENND4A	BAD	0.48	0.058
TFEB	SAMD4A	0.48	0.102
CDC25B	SAMD4A	0.48	0.08
SAMD4A	KIAA0930	0.48	0.048
PFKFB2	SAMD4A	0.48	0.07
SAMD4A	FAM53B	0.48
SAMD4A	BAD	0.48	0.112
TIAM1	SAMD4A	0.48	0.12
KIAA0930	HDAC5	0.477	0.132	mutually_exclusive (P31947)
SAMD4A	IRS2	0.476	0.196
FAM53B	FOXO1	0.472
FOXO3	BRAF	0.471	0.126
BRAF	FAM53B	0.471
BRAF	HDAC5	0.471	0.206
SRGAP2	FOXO3	0.469	0.208
FOXO3	FAM53B	0.466
FAM53B	HDAC5	0.466
DENND4A	BRAF	0.466	0.13	mutually_exclusive (P27348)
BRAF	FOXO1	0.466	0.158	mutually_exclusive (P27348)
SRGAP2	BRAF	0.466	0.144	mutually_exclusive (P27348)
FOXO3	HDAC5	0.463	0.348
DENND4A	SAMD4A	0.461	0.144
HDAC5	FOXO1	0.46	0.15
SPIRE2	FOXO1	0.457
SRGAP2	SPIRE2	0.457
SPIRE2	HDAC5	0.457
SPIRE2	FOXO3	0.457
SPIRE2	FAM53B	0.457
SPIRE2	DENND4A	0.457
DENND4A	FOXO1	0.454	0.076	mutually_exclusive (P27348)
SASH1	PTOV1	0.447	0.08
FOXO3	PTOV1	0.447	0.116
SRGAP2	SMTNL2	0.447		mutually_exclusive (P27348)
SMTNL2	DENND4A	0.447
SYDE2	PTOV1	0.447
PTOV1	BRAF	0.447	0.062
TIAM1	PTOV1	0.447	0.114
PTOV1	PTPN3	0.447	0.108
PTOV1	KIAA0930	0.447	0.094	mutually_exclusive (P31947)
PFKFB2	PTOV1	0.447	0.106
PTOV1	SPIRE1	0.447	0.138
PTOV1	FAM53B	0.447
PTOV1	BAD	0.447	0.094	mutually_exclusive (P31947)
PTOV1	HDAC5	0.447	0.14	mutually_exclusive (P31947)
PACS2	PTOV1	0.447	0.104
TFEB	PTOV1	0.447	0.09
SRGAP2	PTOV1	0.447	0.176
CDC25B	PTOV1	0.447	0.088
BRAF	KIAA0930	0.436	0.11	mutually_exclusive (P27348)
SMTNL2	BRAF	0.426		mutually_exclusive (P27348)
CDC25B	PTPN3	0.385	0.092
SRGAP1	CDC25B	0.385	0.156
SRGAP1	BAD	0.385	0.08
SYDE2	BAD	0.385
PACS2	SPIRE1	0.385	0.092
SYDE2	CDC25B	0.385
PTPN3	BAD	0.385	0.128
PACS2	PFKFB2	0.385	0.064
IRS2	HDAC5	0.353	0.102
SYDE2	FOXO3	0.35
HDAC4	PTPN3	0.324	0.134
SRGAP1	FOXO1	0.324	0.212
SRGAP1	HDAC4	0.324	0.204
FOXO3	FOXO4	0.324
SYDE2	FOXO1	0.324
HDAC4	SYDE2	0.324
SYDE2	FOXO4	0.324
PTPN3	FOXO1	0.324	0.162
SYDE2	IRS2	0.319
FOXO3	PTPN3	0.319	0.2
SRGAP1	TFEB	0.319	0.142
SRGAP1	IRS2	0.319	0.272
SYDE2	TIAM1	0.319
SRGAP1	FOXO3	0.319	0.148
SRGAP1	SYDE2	0.319
SRGAP1	PTPN3	0.319	0.186
SRGAP1	PFKFB2	0.319	0.076
SRGAP1	SPIRE1	0.319	0.156
SRGAP1	FAM53B	0.319
SRGAP1	HDAC5	0.319	0.082
PACS2	FAM53B	0.319
PACS2	SYDE2	0.319
SYDE2	PTPN3	0.319
SYDE2	PFKFB2	0.319
SYDE2	SPIRE1	0.319
SYDE2	FAM53B	0.319
SYDE2	HDAC5	0.319
PTPN3	HDAC5	0.319	0.154
PACS2	HDAC5	0.319	0.096
TFEB	PTPN3	0.319	0.086
PACS2	FOXO1	0.319	0.198
PACS2	SRGAP1	0.319	0.212
PACS2	TFEB	0.319	0.112
PACS2	FOXO3	0.319	0.146
SYDE2	TFEB	0.319
PACS2	PTPN3	0.319	0.088
TIAM1	PTPN3	0.319	0.144
PACS2	HDAC4	0.319	0.15
PFKFB2	PTPN3	0.319	0.084
PTPN3	SPIRE1	0.319	0.13
PTPN3	FAM53B	0.319
SRGAP1	TIAM1	0.319	0.256
PACS2	TIAM1	0.319	0.16
FOXO3	FOXO1	0.317	0.168
SRGAP2	TFEB	0.301	0.154
SRGAP2	HDAC5	0.298	0.208
SRGAP1	KIAA0930	0.29	0.088
SYDE2	KIAA0930	0.29
SRGAP2	SYDE2	0.29
SRGAP1	DENND4A	0.29	0.086
SYDE2	DENND4A	0.29
DENND4A	PTPN3	0.29	0.102
PACS2	BAD	0.29	0.144
PACS2	CDC25B	0.29	0.082
PTPN3	KIAA0930	0.29	0.148
SRGAP2	DENND4A	0.283	0.034
SYDE2	SASH1	0.283
SASH1	PTPN3	0.283	0.09
FOXO4	IRS2	0.283
SASH1	FOXO4	0.283
SRGAP1	SASH1	0.283	0.136
SRGAP1	BRAF	0.283	0.15
PACS2	DENND4A	0.283	0.116
SYDE2	BRAF	0.283
PACS2	BRAF	0.283	0.142
PACS2	SASH1	0.283	0.116
BRAF	PTPN3	0.283	0.104
PACS2	KIAA0930	0.283	0.066
FOXO4	HDAC5	0.283		mutually_exclusive (P31947)
FOXO4	FOXO1	0.283
HDAC4	FOXO4	0.283
FOXO3	DENND4A	0.282	0.1
DENND4A	HDAC5	0.278	0.086
SRGAP2	SAMD4A	0.254	0.14
SPIRE2	SMTNL2	0.246
SMTNL2	TIAM1	0.246
SMTNL2	CDC25B	0.246		mutually_exclusive (P27348)
PACS2	SMTNL2	0.246
SMTNL2	SAMD4A	0.246
SRGAP1	SMTNL2	0.246
PTOV1	FOXO1	0.246	0.142
SMTNL2	KIAA0930	0.246
SMTNL2	FOXO3	0.246
PFKFB2	SMTNL2	0.246		mutually_exclusive (P27348)
SYDE2	SMTNL2	0.246
SMTNL2	PTPN3	0.246
SMTNL2	TFEB	0.246
SMTNL2	FAM53B	0.246
SMTNL2	SPIRE1	0.246
FOXO4	PTOV1	0.239		mutually_exclusive (P31947)
CDC25B	FOXO4	0.238
SPIRE2	FOXO4	0.238
SYDE2	SPIRE2	0.238
SPIRE2	PTPN3	0.238
FOXO4	TIAM1	0.238
FOXO4	SAMD4A	0.238
SRGAP1	SPIRE2	0.238
SRGAP1	PTOV1	0.238	0.118
SRGAP1	FOXO4	0.238
SMTNL2	SASH1	0.238		mutually_exclusive (P27348)
SMTNL2	IRS2	0.238
FOXO4	KIAA0930	0.238		mutually_exclusive (P31947)
PFKFB2	FOXO4	0.238
FOXO4	SPIRE1	0.238
FOXO4	FAM53B	0.238
SMTNL2	BAD	0.238
FOXO4	DENND4A	0.238
PACS2	SAMD4A	0.238	0.076
PACS2	SPIRE2	0.238
FOXO4	BRAF	0.238
SMTNL2	FOXO1	0.238		mutually_exclusive (P27348)
SRGAP1	SAMD4A	0.238	0.246
FOXO4	TFEB	0.238
HDAC4	SMTNL2	0.238
FOXO4	PTPN3	0.238
SMTNL2	HDAC5	0.238		mutually_exclusive (P31947)
SAMD4A	PTPN3	0.238	0.124
SMTNL2	FOXO4	0.238		mutually_exclusive (P31947)
FOXO4	BAD	0.238		mutually_exclusive (P31947)
PACS2	FOXO4	0.238
SYDE2	SAMD4A	0.238
SRGAP2	FOXO4	0.224
PACS2	IRS2	0.213	0.098
SRGAP2	PTPN3	0.191	0.132
DENND4A	PTOV1	0.177	0.034
PACS2	SRGAP2	0.168	0.156133333333
SPIRE2	PTOV1	0.096
SAMD4A	PTOV1	0.096	0.066
SMTNL2	PTOV1	0.069		mutually_exclusive (P31947)

Related Complexes

Genename	Complexes
SMTNL2	huMAP3_02971.1 huMAP3_04537.1 huMAP3_07596.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14527.1
TIAM1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
DENND4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14817.1
PACS2	huMAP3_00173.1 huMAP3_04537.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10190.1 huMAP3_10808.1 huMAP3_12897.1
SAMD4A	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_14098.1
SRGAP1	huMAP3_00235.1 huMAP3_04537.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10496.1 huMAP3_10808.1 huMAP3_11883.1 huMAP3_12561.1 huMAP3_12897.1 huMAP3_13128.1 huMAP3_13156.1 huMAP3_13524.1
TFEB	huMAP3_04102.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_08832.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13402.1 huMAP3_13503.1
CDC25B	huMAP3_03088.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07002.1 huMAP3_07596.1 huMAP3_07691.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10829.1 huMAP3_12772.1 huMAP3_12897.1
IRS2	huMAP3_04537.1 huMAP3_07081.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_08092.1 huMAP3_09358.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_11629.1 huMAP3_12185.1 huMAP3_12897.1 huMAP3_14118.1
SPATA13	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SPIRE2	huMAP3_02462.1 huMAP3_04537.1 huMAP3_06108.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13929.1 huMAP3_15248.1
SASH1	huMAP3_03955.1 huMAP3_04051.1 huMAP3_04537.1 huMAP3_07306.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
FOXO3	huMAP3_03955.1 huMAP3_04051.1 huMAP3_04537.1 huMAP3_06135.1 huMAP3_07306.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SYDE2	huMAP3_00566.1 huMAP3_04537.1 huMAP3_06797.1 huMAP3_06971.1 huMAP3_08480.1 huMAP3_08492.1 huMAP3_09272.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10974.1 huMAP3_12897.1 huMAP3_14687.1
PTOV1	huMAP3_04537.1 huMAP3_05308.1 huMAP3_07324.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_08154.1 huMAP3_09641.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1
LNP1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13672.1
BRAF	huMAP3_04537.1 huMAP3_04917.1 huMAP3_07588.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11448.1 huMAP3_12897.1
PTPN3	huMAP3_04537.1 huMAP3_06025.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11201.1 huMAP3_12897.1
KIAA0930	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11622.1 huMAP3_12897.1
PFKFB2	huMAP3_01672.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SPIRE1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1 huMAP3_13929.1 huMAP3_15248.1
FAM53B	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
BAD	huMAP3_04537.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_11267.1 huMAP3_12897.1 huMAP3_13356.1
YWHAH	huMAP3_04051.1 huMAP3_04537.1 huMAP3_06971.1 huMAP3_07306.1 huMAP3_07596.1 huMAP3_08480.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
HDAC5	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
FOXO1	huMAP3_04537.1 huMAP3_06971.1 huMAP3_07424.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
HDAC4	huMAP3_00531.1 huMAP3_04537.1 huMAP3_06269.1 huMAP3_07596.1 huMAP3_07838.1 huMAP3_09641.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_10898.1 huMAP3_12897.1 huMAP3_14118.1
FOXO4	huMAP3_04051.1 huMAP3_04537.1 huMAP3_07424.1 huMAP3_08480.1 huMAP3_09810.1 huMAP3_10808.1 huMAP3_12897.1
SRGAP2	huMAP3_00235.1 huMAP3_02549.1 huMAP3_04537.1 huMAP3_05977.1 huMAP3_07838.1 huMAP3_08222.1 huMAP3_09542.1 huMAP3_09810.1 huMAP3_10496.1 huMAP3_10808.1 huMAP3_11531.1 huMAP3_12897.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04537.1

Complex Portal: CPX-10863