hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04542.1
Complex Portal: CPX-13832
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| FBRSL1 | Fibrosin-1-like protein (AUTS2-like protein) (HBV X-transactivated gene 9 protein) (HBV XAg-transactivated protein 9) | 3 | UniProt NCBI |
| AUTS2 | Autism susceptibility gene 2 protein | 5 | UniProt NCBI |
| RING1 | E3 ubiquitin-protein ligase RING1 (EC 2.3.2.27) (Polycomb complex protein RING1) (RING finger protein 1) (RING-type E3 ubiquitin transferase RING1) (Really interesting new gene 1 protein) | 5 | UniProt NCBI |
| KDM2B | Lysine-specific demethylase 2B (EC 1.14.11.27) (CXXC-type zinc finger protein 2) (F-box and leucine-rich repeat protein 10) (F-box protein FBL10) (F-box/LRR-repeat protein 10) (JmjC domain-containing histone demethylation protein 1B) (Jumonji domain-containing EMSY-interactor methyltransferase motif protein) (Protein JEMMA) (Protein-containing CXXC domain 2) ([Histone-H3]-lysine-36 demethylase 1B) | 5 | UniProt NCBI |
| PCGF3 | Polycomb group RING finger protein 3 (RING finger protein 3A) | 5 | UniProt NCBI |
| FBRS | Probable fibrosin-1 | 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03083 | 1.24235802028e-12 | 1.0 | FBRSL1 PCGF3 RING1 FBRS KDM2B AUTS2 | Polycomb repressive complex |
| CORUM:1178 | 0.000358512652571 | 0.333333333333 | RING1 KDM2B | BCOR complex |
| REAC:R-HSA-8939243 | 0.0161658624528 | 0.333333333333 | AUTS2 RING1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| GO:0031519 | 0.0219369042126 | 0.5 | PCGF3 RING1 KDM2B | PcG protein complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| RING1 | FBRS | 1.0 | 0.07 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () boldt_WMM | |
| RING1 | PCGF3 | 0.998 | 0.08 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 boldt_WMM WMM_only | |
| PCGF3 | FBRS | 0.998 | 0.144 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| FBRSL1 | FBRS | 0.998 | 0.094 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| FBRSL1 | PCGF3 | 0.997 | 0.124 |
structurally_consistent (dimer)
|
bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only |
| FBRSL1 | RING1 | 0.994 | 0.094 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| KDM2B | RING1 | 0.985 | 0.142 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| AUTS2 | FBRS | 0.974 | 0.048 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| FBRSL1 | AUTS2 | 0.97 | 0.084 |
mutually_exclusive (P61962)
|
bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only |
| AUTS2 | RING1 | 0.97 | 0.092 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only boldt_WMM | |
| AUTS2 | PCGF3 | 0.956 | 0.052 | bioplex_WMM bioplex3_WMM boldt boldt_WMM WMM_only | |
| KDM2B | FBRS | 0.937 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | |
| KDM2B | AUTS2 | 0.397 | 0.104 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| KDM2B | FBRSL1 | 0.352 | 0.13 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | |
| KDM2B | PCGF3 | 0.291 | 0.13 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes