hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04546.1
Complex Portal: CPX-12385
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ESPL1 | Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase) | 5 | UniProt NCBI |
| PTTG1 | Securin (Esp1-associated protein) (Pituitary tumor-transforming gene 1 protein) (Tumor-transforming protein 1) (hPTTG) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:5642 | 1.70876175213e-06 | 1.0 | PTTG1 ESPL1 | Securin-separase complex |
| WP:WP4240 | 3.87329686614e-05 | 1.0 | PTTG1 ESPL1 | Regulation of sister chromatid separation at the metaphase anaphase transition |
| WP:WP5117 | 0.00019792121349 | 1.0 | PTTG1 ESPL1 | Cohesin complex Cornelia de Lange syndrome |
| KEGG:04114 | 0.000870723283599 | 1.0 | PTTG1 ESPL1 | Oocyte meiosis |
| KEGG:04110 | 0.00184110178991 | 1.0 | PTTG1 ESPL1 | Cell cycle |
| WP:WP179 | 0.00283899891178 | 1.0 | PTTG1 ESPL1 | Cell cycle |
| KEGG:05166 | 0.00317059675131 | 1.0 | PTTG1 ESPL1 | Human T-cell leukemia virus 1 infection |
| REAC:R-HSA-2467813 | 0.0287687128588 | 1.0 | PTTG1 ESPL1 | Separation of Sister Chromatids |
| REAC:R-HSA-68882 | 0.0422969796504 | 1.0 | PTTG1 ESPL1 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0426780335212 | 1.0 | PTTG1 ESPL1 | Mitotic Metaphase and Anaphase |
| CORUM:5643 | 0.0499419797295 | 0.5 | ESPL1 | ESPL1-CDC2 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ESPL1 | PTTG1 | 0.997 | 0.11 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
Related Complexes