hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04548.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NUP160 | Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160) | 5 | UniProt NCBI |
| NUP85 | Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:87 | 6.15154230766e-05 | 1.0 | NUP160 NUP85 | Nup 107-160 subcomplex |
| HP:0012588 | 0.000358839967947 | 1.0 | NUP160 NUP85 | Steroid-resistant nephrotic syndrome |
| REAC:R-HSA-9615933 | 0.000471618243588 | 1.0 | NUP160 NUP85 | Postmitotic nuclear pore complex (NPC) reformation |
| REAC:R-HSA-170822 | 0.000645911942305 | 1.0 | NUP160 NUP85 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 0.000645911942305 | 1.0 | NUP160 NUP85 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168333 | 0.000693757271364 | 1.0 | NUP160 NUP85 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 0.000693757271364 | 1.0 | NUP160 NUP85 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-168271 | 0.000693757271364 | 1.0 | NUP160 NUP85 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-159227 | 0.00079457421474 | 1.0 | NUP160 NUP85 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180910 | 0.00079457421474 | 1.0 | NUP160 NUP85 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-180746 | 0.00079457421474 | 1.0 | NUP160 NUP85 | Nuclear import of Rev protein |
| KEGG:03013 | 0.000820976957091 | 1.0 | NUP160 NUP85 | Nucleocytoplasmic transport |
| REAC:R-HSA-4085377 | 0.000847545829056 | 1.0 | NUP160 NUP85 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-165054 | 0.000847545829056 | 1.0 | NUP160 NUP85 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-159230 | 0.000847545829056 | 1.0 | NUP160 NUP85 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-3301854 | 0.000902226205124 | 1.0 | NUP160 NUP85 | Nuclear Pore Complex (NPC) Disassembly |
| HP:0031504 | 0.000943236487175 | 1.0 | NUP160 NUP85 | Foamy urine |
| REAC:R-HSA-176033 | 0.000958615342944 | 1.0 | NUP160 NUP85 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 0.000958615342944 | 1.0 | NUP160 NUP85 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 0.00101671324252 | 1.0 | NUP160 NUP85 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 0.00113803532692 | 1.0 | NUP160 NUP85 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 0.00120125951175 | 1.0 | NUP160 NUP85 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 0.00126619245833 | 1.0 | NUP160 NUP85 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 0.00133283416666 | 1.0 | NUP160 NUP85 | Viral Messenger RNA Synthesis |
| HP:0012579 | 0.00138751454273 | 1.0 | NUP160 NUP85 | Minimal change glomerulonephritis |
| WP:WP3998 | 0.00144844277313 | 1.0 | NUP160 NUP85 | Prader Willi and Angelman syndrome |
| REAC:R-HSA-4615885 | 0.00147124386858 | 1.0 | NUP160 NUP85 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-4570464 | 0.00154301186217 | 1.0 | NUP160 NUP85 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-2980766 | 0.00184717145405 | 1.0 | NUP160 NUP85 | Nuclear Envelope Breakdown |
| HP:0001967 | 0.00191723068589 | 1.0 | NUP160 NUP85 | Diffuse mesangial sclerosis |
| HP:0002586 | 0.00203342648503 | 1.0 | NUP160 NUP85 | Peritonitis |
| REAC:R-HSA-191859 | 0.00217867123396 | 1.0 | NUP160 NUP85 | snRNP Assembly |
| REAC:R-HSA-194441 | 0.00217867123396 | 1.0 | NUP160 NUP85 | Metabolism of non-coding RNA |
| REAC:R-HSA-6784531 | 0.00253751120191 | 1.0 | NUP160 NUP85 | tRNA processing in the nucleus |
| HP:0001966 | 0.00280236927349 | 1.0 | NUP160 NUP85 | Abnormal glomerular mesangium morphology |
| HP:0033072 | 0.00353713682691 | 1.0 | NUP160 NUP85 | Abnormal macroscopic urine appearance |
| REAC:R-HSA-70171 | 0.00355422444443 | 1.0 | NUP160 NUP85 | Glycolysis |
| REAC:R-HSA-3371453 | 0.00355422444443 | 1.0 | NUP160 NUP85 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-1169408 | 0.00366529395832 | 1.0 | NUP160 NUP85 | ISG15 antiviral mechanism |
| REAC:R-HSA-4551638 | 0.00366529395832 | 1.0 | NUP160 NUP85 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-2995410 | 0.00377807223396 | 1.0 | NUP160 NUP85 | Nuclear Envelope (NE) Reassembly |
| REAC:R-HSA-5619102 | 0.00412665963139 | 1.0 | NUP160 NUP85 | SLC transporter disorders |
| REAC:R-HSA-159236 | 0.00412665963139 | 1.0 | NUP160 NUP85 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.00424627295404 | 1.0 | NUP160 NUP85 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.00436759503844 | 1.0 | NUP160 NUP85 | Antiviral mechanism by IFN-stimulated genes |
| HP:0002585 | 0.00489047613459 | 1.0 | NUP160 NUP85 | Abnormal peritoneum morphology |
| HP:0000097 | 0.00507502240382 | 1.0 | NUP160 NUP85 | Focal segmental glomerulosclerosis |
| REAC:R-HSA-72202 | 0.00526469495831 | 1.0 | NUP160 NUP85 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-70326 | 0.00526469495831 | 1.0 | NUP160 NUP85 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.0061002794551 | 1.0 | NUP160 NUP85 | Cellular response to heat stress |
| REAC:R-HSA-5578749 | 0.00699737937497 | 1.0 | NUP160 NUP85 | Transcriptional regulation by small RNAs |
| REAC:R-HSA-141424 | 0.00715287669441 | 1.0 | NUP160 NUP85 | Amplification of signal from the kinetochores |
| REAC:R-HSA-141444 | 0.00715287669441 | 1.0 | NUP160 NUP85 | Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal |
| REAC:R-HSA-72306 | 0.00828920325958 | 1.0 | NUP160 NUP85 | tRNA processing |
| REAC:R-HSA-9610379 | 0.00828920325958 | 1.0 | NUP160 NUP85 | HCMV Late Events |
| KEGG:05014 | 0.00850662183301 | 1.0 | NUP160 NUP85 | Amyotrophic lateral sclerosis |
| HP:0000099 | 0.00948362772432 | 1.0 | NUP160 NUP85 | Glomerulonephritis |
| HP:0045073 | 0.00973994198714 | 1.0 | NUP160 NUP85 | Serositis |
| REAC:R-HSA-69618 | 0.0098732254038 | 1.0 | NUP160 NUP85 | Mitotic Spindle Checkpoint |
| REAC:R-HSA-9705671 | 0.0106216630512 | 1.0 | NUP160 NUP85 | SARS-CoV-2 activates/modulates innate and adaptive immune responses |
| REAC:R-HSA-9648025 | 0.0108130443675 | 1.0 | NUP160 NUP85 | EML4 and NUDC in mitotic spindle formation |
| HP:0000096 | 0.0110727761538 | 1.0 | NUP160 NUP85 | Glomerular sclerosis |
| REAC:R-HSA-211000 | 0.0117955823749 | 1.0 | NUP160 NUP85 | Gene Silencing by RNA |
| REAC:R-HSA-9609690 | 0.0122005589102 | 1.0 | NUP160 NUP85 | HCMV Early Events |
| REAC:R-HSA-2500257 | 0.0124056103205 | 1.0 | NUP160 NUP85 | Resolution of Sister Chromatid Cohesion |
| REAC:R-HSA-68875 | 0.0126123704925 | 1.0 | NUP160 NUP85 | Mitotic Prophase |
| REAC:R-HSA-162909 | 0.013242903579 | 1.0 | NUP160 NUP85 | Host Interactions of HIV factors |
| REAC:R-HSA-162599 | 0.0143279672916 | 1.0 | NUP160 NUP85 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-168273 | 0.0145501063194 | 1.0 | NUP160 NUP85 | Influenza Viral RNA Transcription and Replication |
| HP:0100539 | 0.0146201655512 | 1.0 | NUP160 NUP85 | Periorbital edema |
| REAC:R-HSA-5663220 | 0.0147739541089 | 1.0 | NUP160 NUP85 | RHO GTPases Activate Formins |
| HP:0003073 | 0.0159119894358 | 1.0 | NUP160 NUP85 | Hypoalbuminemia |
| HP:0012116 | 0.0159119894358 | 1.0 | NUP160 NUP85 | Abnormal circulating albumin concentration |
| HP:0000123 | 0.0165784065192 | 1.0 | NUP160 NUP85 | Nephritis |
| REAC:R-HSA-5619115 | 0.0168654784935 | 1.0 | NUP160 NUP85 | Disorders of transmembrane transporters |
| REAC:R-HSA-162587 | 0.0171064139006 | 1.0 | NUP160 NUP85 | HIV Life Cycle |
| REAC:R-HSA-9609646 | 0.0171064139006 | 1.0 | NUP160 NUP85 | HCMV Infection |
| REAC:R-HSA-168255 | 0.0185879103397 | 1.0 | NUP160 NUP85 | Influenza Infection |
| HP:0000100 | 0.0197464508076 | 1.0 | NUP160 NUP85 | Nephrotic syndrome |
| HP:0000282 | 0.020488053408 | 1.0 | NUP160 NUP85 | Facial edema |
| GO:0031080 | 0.0210690324038 | 1.0 | NUP160 NUP85 | nuclear pore outer ring |
| REAC:R-HSA-3108232 | 0.0211937720117 | 1.0 | NUP160 NUP85 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 0.0225607814134 | 1.0 | NUP160 NUP85 | SUMOylation |
| HP:0003774 | 0.0227948817734 | 1.0 | NUP160 NUP85 | Stage 5 chronic kidney disease |
| REAC:R-HSA-913531 | 0.0260158976762 | 1.0 | NUP160 NUP85 | Interferon Signaling |
| REAC:R-HSA-2467813 | 0.0287687128588 | 1.0 | NUP160 NUP85 | Separation of Sister Chromatids |
| REAC:R-HSA-9705683 | 0.0300366140789 | 1.0 | NUP160 NUP85 | SARS-CoV-2-host interactions |
| REAC:R-HSA-68877 | 0.0323212285415 | 1.0 | NUP160 NUP85 | Mitotic Prometaphase |
| REAC:R-HSA-162906 | 0.0415399981943 | 1.0 | NUP160 NUP85 | HIV Infection |
| REAC:R-HSA-68882 | 0.0422969796504 | 1.0 | NUP160 NUP85 | Mitotic Anaphase |
| REAC:R-HSA-2555396 | 0.0426780335212 | 1.0 | NUP160 NUP85 | Mitotic Metaphase and Anaphase |
| HP:0000095 | 0.044567924019 | 1.0 | NUP160 NUP85 | Abnormal renal glomerulus morphology |
| HP:0031263 | 0.0451215628267 | 1.0 | NUP160 NUP85 | Abnormal renal corpuscle morphology |
| HP:0012622 | 0.0468029843908 | 1.0 | NUP160 NUP85 | Chronic kidney disease |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NUP160 | NUP85 | 0.998 | 0.974 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM |
Related Complexes