hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04552.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| C16orf96 | Uncharacterized protein C16orf96 | 2 | UniProt NCBI |
| SOS2 | Son of sevenless homolog 2 (SOS-2) | 5 | UniProt NCBI |
| GRB2 | Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2) | 5 | UniProt NCBI |
| GAREM2 | GRB2-associated and regulator of MAPK protein 2 (GRB2-associated and regulator of MAPK1-like) | 3 | UniProt NCBI |
| GAREM1 | GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4928 | 0.000534376000489 | 0.4 | SOS2 GAREM2 | MAPK pathway in congenital thyroid cancer |
| REAC:R-HSA-8983432 | 0.0011839189519 | 0.4 | SOS2 GRB2 | Interleukin-15 signaling |
| WP:WP422 | 0.00205749802636 | 0.4 | SOS2 GRB2 | MAPK cascade |
| WP:WP4535 | 0.0041146517648 | 0.4 | SOS2 GRB2 | Envelope proteins and their potential roles in EDMD physiopathology |
| KEGG:05213 | 0.00598637208626 | 0.4 | SOS2 GRB2 | Endometrial cancer |
| KEGG:04664 | 0.00622027886669 | 0.4 | SOS2 GRB2 | Fc epsilon RI signaling pathway |
| KEGG:05221 | 0.00771708586936 | 0.4 | SOS2 GRB2 | Acute myeloid leukemia |
| REAC:R-HSA-451927 | 0.00799229651072 | 0.4 | SOS2 GRB2 | Interleukin-2 family signaling |
| KEGG:04917 | 0.00852542753416 | 0.4 | SOS2 GRB2 | Prolactin signaling pathway |
| WP:WP4205 | 0.00931707261303 | 0.4 | SOS2 GRB2 | MET in type 1 papillary renal cell carcinoma |
| WP:WP4155 | 0.00931707261303 | 0.4 | SOS2 GRB2 | Endometrial cancer |
| KEGG:05211 | 0.00937366158534 | 0.4 | SOS2 GRB2 | Renal cell carcinoma |
| WP:WP5293 | 0.00998567643899 | 0.4 | SOS2 GRB2 | Acute myeloid leukemia |
| KEGG:05223 | 0.0102617382696 | 0.4 | SOS2 GRB2 | Non-small cell lung cancer |
| KEGG:04912 | 0.0102617382696 | 0.4 | SOS2 GRB2 | GnRH signaling pathway |
| KEGG:04662 | 0.0102617382696 | 0.4 | SOS2 GRB2 | B cell receptor signaling pathway |
| KEGG:05214 | 0.0102617382696 | 0.4 | SOS2 GRB2 | Glioma |
| WP:WP4685 | 0.010328593539 | 0.4 | SOS2 GRB2 | Melanoma |
| KEGG:04540 | 0.0111896078643 | 0.4 | SOS2 GRB2 | Gap junction |
| KEGG:05220 | 0.012157220678 | 0.4 | SOS2 GRB2 | Chronic myeloid leukemia |
| KEGG:01521 | 0.012157220678 | 0.4 | SOS2 GRB2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04012 | 0.0128243509281 | 0.4 | SOS2 GRB2 | ErbB signaling pathway |
| WP:WP4255 | 0.0128896073912 | 0.4 | SOS2 GRB2 | Non small cell lung cancer |
| KEGG:05210 | 0.0135091080522 | 0.4 | SOS2 GRB2 | Colorectal cancer |
| KEGG:01522 | 0.0149314441262 | 0.4 | SOS2 GRB2 | Endocrine resistance |
| KEGG:05231 | 0.0152980219787 | 0.4 | SOS2 GRB2 | Choline metabolism in cancer |
| WP:WP4806 | 0.0179319533427 | 0.4 | SOS2 GRB2 | EGFR tyrosine kinase inhibitor resistance |
| KEGG:05215 | 0.0179869923441 | 0.4 | SOS2 GRB2 | Prostate cancer |
| KEGG:04915 | 0.0187947263105 | 0.4 | SOS2 GRB2 | Estrogen signaling pathway |
| WP:WP673 | 0.0188521857166 | 0.4 | SOS2 GRB2 | ErbB signaling pathway |
| KEGG:04722 | 0.0222006100833 | 0.4 | SOS2 GRB2 | Neurotrophin signaling pathway |
| KEGG:04935 | 0.0222006100833 | 0.4 | SOS2 GRB2 | Growth hormone synthesis, secretion and action |
| KEGG:04660 | 0.0235498516465 | 0.4 | SOS2 GRB2 | T cell receptor signaling pathway |
| WP:WP4321 | 0.0237943842002 | 0.4 | SOS2 GRB2 | Thermogenesis |
| KEGG:04926 | 0.0258857078716 | 0.4 | SOS2 GRB2 | Relaxin signaling pathway |
| KEGG:04650 | 0.0263659307172 | 0.4 | SOS2 GRB2 | Natural killer cell mediated cytotoxicity |
| KEGG:04068 | 0.028330266578 | 0.4 | SOS2 GRB2 | FoxO signaling pathway |
| WP:WP710 | 0.0293032373139 | 0.4 | SOS2 GRB2 | DNA damage response only ATM dependent |
| KEGG:04072 | 0.029849084091 | 0.4 | SOS2 GRB2 | Phospholipase D signaling pathway |
| KEGG:04910 | 0.0351932106204 | 0.4 | SOS2 GRB2 | Insulin signaling pathway |
| KEGG:05224 | 0.035751387428 | 0.4 | SOS2 GRB2 | Breast cancer |
| KEGG:04630 | 0.0380272112444 | 0.4 | SOS2 GRB2 | JAK-STAT signaling pathway |
| KEGG:05160 | 0.0380272112444 | 0.4 | SOS2 GRB2 | Hepatitis C |
| KEGG:05226 | 0.0380272112444 | 0.4 | SOS2 GRB2 | Gastric cancer |
| WP:WP3929 | 0.0420114386662 | 0.4 | SOS2 GRB2 | Chemokine signaling pathway |
| KEGG:04062 | 0.0427854405203 | 0.4 | SOS2 GRB2 | Chemokine signaling pathway |
| KEGG:04150 | 0.0484667159694 | 0.4 | SOS2 GRB2 | mTOR signaling pathway |
| KEGG:05206 | 0.0484667159694 | 0.4 | SOS2 GRB2 | MicroRNAs in cancer |
| KEGG:05161 | 0.0484667159694 | 0.4 | SOS2 GRB2 | Hepatitis B |
| KEGG:05034 | 0.0491193697999 | 0.4 | SOS2 GRB2 | Alcoholism |
| CORUM:3096 | 0.0498708842806 | 0.2 | GRB2 | ITGA6-ITGB4-SHC1-GRB2 complex |
| CORUM:2895 | 0.0498708842806 | 0.2 | GRB2 | SHC-GRB2 complex |
| CORUM:2892 | 0.0498708842806 | 0.2 | GRB2 | BCR-ABL (p185 fusion protein)-GRB2 complex |
| CORUM:2540 | 0.0498708842806 | 0.2 | GRB2 | BCR-ABL (p210 fusion protein)-GRB2 complex |
| WP:WP4239 | 0.0499562127809 | 0.4 | SOS2 GRB2 | Epithelial to mesenchymal transition in colorectal cancer |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SOS2 | GRB2 | 1.0 | 0.192 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GRB2 | GAREM1 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| GAREM2 | GAREM1 | 0.998 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| GRB2 | GAREM2 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | GRB2 | 0.968 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| C16orf96 | SOS2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | GAREM2 | 0.557 | bioplex_WMM bioplex3_WMM WMM_only | |
| C16orf96 | GAREM1 | 0.543 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GAREM2 | 0.487 | bioplex_WMM bioplex3_WMM WMM_only | |
| SOS2 | GAREM1 | 0.303 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes