hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04554.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| POLD2 | DNA polymerase delta subunit 2 (DNA polymerase delta subunit p50) | 5 | UniProt NCBI |
| POLD3 | DNA polymerase delta subunit 3 (DNA polymerase delta subunit C) (DNA polymerase delta subunit p66) (DNA polymerase delta subunit p68) | 5 | UniProt NCBI |
| POLD1 | DNA polymerase delta catalytic subunit (EC 2.7.7.7) (3'-5' exodeoxyribonuclease) (EC 3.1.11.-) (DNA polymerase subunit delta p125) | 5 | UniProt NCBI |
| REV3L | DNA polymerase zeta catalytic subunit (EC 2.7.7.7) (Protein reversionless 3-like) (REV3-like) (hREV3) | 5 | UniProt NCBI |
| POLD4 | DNA polymerase delta subunit 4 (DNA polymerase delta subunit p12) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:297 | 3.83566049696e-13 | 0.8 | POLD2 POLD4 POLD1 POLD3 | PCNA-DNA polymerase delta complex |
| REAC:R-HSA-110313 | 1.46742920896e-11 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-73893 | 4.48447608162e-11 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA Damage Bypass |
| CORUM:1107 | 4.831609132e-11 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA synthesome core complex |
| CORUM:1098 | 8.05224085528e-11 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA synthesome complex (13 subunits) |
| WP:WP186 | 8.17779344691e-11 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Homologous recombination |
| GO:0043625 | 1.31563155046e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | delta DNA polymerase complex |
| GO:0042575 | 1.39604076095e-10 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA polymerase complex |
| CORUM:1108 | 2.74114580914e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 3.83739390783e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 3.83739390783e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69091 | 4.27346139736e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Polymerase switching |
| REAC:R-HSA-5358565 | 4.27346139736e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) |
| REAC:R-HSA-69166 | 4.27346139736e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Removal of the Flap Intermediate |
| REAC:R-HSA-5358606 | 4.27346139736e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) |
| REAC:R-HSA-69109 | 4.27346139736e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Leading Strand Synthesis |
| REAC:R-HSA-5358508 | 5.82712811345e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Mismatch Repair |
| REAC:R-HSA-69183 | 5.82712811345e-10 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Processive synthesis on the lagging strand |
| REAC:R-HSA-174437 | 1.01590075431e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Removal of the Flap Intermediate from the C-strand |
| KEGG:03430 | 1.1298832844e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Mismatch repair |
| WP:WP531 | 1.46203490319e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA mismatch repair |
| WP:WP4946 | 1.58781044075e-09 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA repair pathways full network |
| REAC:R-HSA-174414 | 1.65428563873e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Processive synthesis on the C-strand of the telomere |
| REAC:R-HSA-69186 | 2.06774373342e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Lagging Strand Synthesis |
| REAC:R-HSA-5651801 | 2.55413169334e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | PCNA-Dependent Long Patch Base Excision Repair |
| GO:0000731 | 2.92311341789e-09 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA synthesis involved in DNA repair |
| WP:WP4752 | 4.52305973006e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Base excision repair |
| REAC:R-HSA-110373 | 5.39727369539e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| REAC:R-HSA-5696397 | 5.39727369539e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-174411 | 6.37824653444e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Polymerase switching on the C-strand of the telomere |
| KEGG:03030 | 7.51082457735e-09 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA replication |
| KEGG:03440 | 1.16503464997e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Homologous recombination |
| REAC:R-HSA-110314 | 1.16894660556e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-5656169 | 1.34205029003e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Termination of translesion DNA synthesis |
| REAC:R-HSA-69190 | 1.53368765668e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA strand elongation |
| KEGG:03410 | 1.57296490579e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Base excision repair |
| WP:WP466 | 1.84613378839e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA replication |
| REAC:R-HSA-174417 | 1.97771129067e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Telomere C-strand (Lagging Strand) Synthesis |
| WP:WP4753 | 2.03536916201e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Nucleotide excision repair |
| REAC:R-HSA-73933 | 2.23277738459e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-5696400 | 4.31701598099e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Dual Incision in GG-NER |
| KEGG:03420 | 5.40322943081e-08 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Nucleotide excision repair |
| REAC:R-HSA-180786 | 1.06470860481e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Extension of Telomeres |
| WP:WP5114 | 1.79216443484e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Nucleotide excision repair in xeroderma pigmentosum |
| REAC:R-HSA-6782210 | 2.53618197426e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-6782135 | 2.70511217063e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Dual incision in TC-NER |
| REAC:R-HSA-5685942 | 3.06812697185e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | HDR through Homologous Recombination (HRR) |
| GO:0003887 | 5.09519976729e-07 | 0.8 | POLD3 POLD4 REV3L POLD1 | DNA-directed DNA polymerase activity |
| REAC:R-HSA-73884 | 5.45866299098e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Base Excision Repair |
| REAC:R-HSA-6781827 | 5.75745130806e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-73894 | 6.32509128099e-07 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA Repair |
| REAC:R-HSA-5696399 | 7.8154979472e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Global Genome Nucleotide Excision Repair (GG-NER) |
| GO:0043601 | 9.61435992643e-07 | 0.8 | POLD2 POLD4 POLD1 POLD3 | nuclear replisome |
| GO:0019985 | 1.16377978294e-06 | 0.8 | POLD2 REV3L POLD1 POLD3 | translesion synthesis |
| GO:0030894 | 1.396459195e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | replisome |
| GO:0034061 | 1.66236029818e-06 | 0.8 | POLD3 POLD4 REV3L POLD1 | DNA polymerase activity |
| REAC:R-HSA-157579 | 1.66615928446e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Telomere Maintenance |
| REAC:R-HSA-5696398 | 2.27611882554e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Nucleotide Excision Repair |
| REAC:R-HSA-69239 | 3.37055878382e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Synthesis of DNA |
| GO:0016035 | 3.84440695359e-06 | 0.6 | POLD2 REV3L POLD3 | zeta DNA polymerase complex |
| REAC:R-HSA-5693567 | 3.85269753617e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| GO:0006261 | 3.89255444008e-06 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA-templated DNA replication |
| GO:0071897 | 4.18080029939e-06 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA biosynthetic process |
| REAC:R-HSA-73886 | 4.38473721467e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Chromosome Maintenance |
| REAC:R-HSA-5693538 | 4.67050314665e-06 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Homology Directed Repair |
| GO:0006301 | 4.72375798258e-06 | 0.8 | POLD2 REV3L POLD1 POLD3 | postreplication repair |
| REAC:R-HSA-5693532 | 1.05854142603e-05 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA Double-Strand Break Repair |
| GO:0043596 | 1.08004637014e-05 | 0.8 | POLD2 POLD4 POLD1 POLD3 | nuclear replication fork |
| REAC:R-HSA-69242 | 1.08579866423e-05 | 0.8 | POLD2 POLD4 POLD1 POLD3 | S Phase |
| REAC:R-HSA-69306 | 1.56110049701e-05 | 0.8 | POLD2 POLD4 POLD1 POLD3 | DNA Replication |
| GO:0006260 | 3.28944967066e-05 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA replication |
| GO:0005657 | 8.87760174517e-05 | 0.8 | POLD2 POLD4 POLD1 POLD3 | replication fork |
| GO:0061695 | 0.000115876930584 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | transferase complex, transferring phosphorus-containing groups |
| GO:0042276 | 0.000158467845213 | 0.6 | POLD2 REV3L POLD3 | error-prone translesion synthesis |
| GO:0016779 | 0.000472796969853 | 0.8 | POLD3 POLD4 REV3L POLD1 | nucleotidyltransferase activity |
| REAC:R-HSA-69278 | 0.00130844914147 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Cell Cycle, Mitotic |
| GO:0006281 | 0.00195208595796 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA repair |
| REAC:R-HSA-1640170 | 0.00298118644627 | 0.8 | POLD2 POLD4 POLD1 POLD3 | Cell Cycle |
| GO:0000228 | 0.00469791606681 | 0.8 | POLD2 POLD4 POLD1 POLD3 | nuclear chromosome |
| GO:0140097 | 0.00729542990987 | 0.8 | POLD3 POLD4 REV3L POLD1 | catalytic activity, acting on DNA |
| GO:0006974 | 0.0141199763351 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA damage response |
| GO:0006259 | 0.0192772113985 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | DNA metabolic process |
| GO:1990234 | 0.0209786718727 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | transferase complex |
| GO:0140535 | 0.0279888888248 | 1.0 | POLD2 POLD4 REV3L POLD1 POLD3 | intracellular protein-containing complex |
| GO:0006297 | 0.0468008499735 | 0.4 | POLD3 POLD1 | nucleotide-excision repair, DNA gap filling |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| POLD2 | POLD1 | 1.0 | 0.766 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein () Malo bioplex3_HCT116 fraction |
| POLD4 | POLD1 | 0.999 | 0.214 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| POLD2 | POLD3 | 0.997 | 0.67 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| POLD2 | REV3L | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| POLD2 | POLD4 | 0.996 | 0.122 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| POLD3 | POLD1 | 0.988 | 0.646 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 fraction boldt_WMM |
| POLD4 | REV3L | 0.912 | bioplex_WMM bioplex3_WMM WMM_only | |
| POLD4 | POLD3 | 0.898 | 0.094 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| REV3L | POLD3 | 0.473 | bioplex_WMM bioplex3_WMM WMM_only | |
| REV3L | POLD1 | 0.452 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only |
Related Complexes
| Genename | Complexes |
|---|---|
| POLD2 | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |
| POLD3 | huMAP3_04554.1 |
| POLD1 | huMAP3_04554.1 huMAP3_07550.1 huMAP3_08117.1 |
| REV3L | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |
| POLD4 | huMAP3_03515.1 huMAP3_04554.1 huMAP3_08117.1 huMAP3_13172.1 |