hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04559.1
Complex Portal: CPX-24328
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRMT10A | tRNA methyltransferase 10 homolog A (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 2) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10A) | 5 | UniProt NCBI |
| SYT2 | Synaptotagmin-2 (Synaptotagmin II) (SytII) | 5 | UniProt NCBI |
| ARHGAP10 | Rho GTPase-activating protein 10 (GTPase regulator associated with focal adhesion kinase 2) (GRAF2) (Graf-related protein 2) (Rho-type GTPase-activating protein 10) | 5 | UniProt NCBI |
| ROR1 | Inactive tyrosine-protein kinase transmembrane receptor ROR1 (Neurotrophic tyrosine kinase, receptor-related 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001620 | 0.0273256954732 | 0.5 | TRMT10A SYT2 | High pitched voice |
| HP:5200005 | 0.0458701548093 | 0.5 | TRMT10A SYT2 | Abnormal pitch |
| CORUM:5274 | 0.049938562206 | 0.25 | ARHGAP10 | Cell-cell junction complex (ARHGAP10-CTNNA1) |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| ARHGAP10 | SYT2 | 0.972 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| TRMT10A | SYT2 | 0.971 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ROR1 | SYT2 | 0.969 | bioplex3_HEK293 bioplex3_WMM WMM_only | ||
| ROR1 | TRMT10A | 0.415 | 0.054 | bioplex3_WMM WMM_only | |
| ARHGAP10 | TRMT10A | 0.415 | 0.09 | bioplex3_WMM WMM_only | |
| ROR1 | ARHGAP10 | 0.21 | 0.108 | bioplex3_WMM WMM_only |
Related Complexes