hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04582.1

Complex Portal: CPX-13768

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
TSEN54	tRNA-splicing endonuclease subunit Sen54 (SEN54 homolog) (HsSEN54) (tRNA-intron endonuclease Sen54)	5	UniProt NCBI
PHLDA2	Pleckstrin homology-like domain family A member 2 (Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein) (Imprinted in placenta and liver protein) (Tumor-suppressing STF cDNA 3 protein) (Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein) (p17-Beckwith-Wiedemann region 1 C) (p17-BWR1C)	5	UniProt NCBI
AMMECR1	Nuclear protein AMMECR1 (AMME syndrome candidate gene 1 protein)	5	UniProt NCBI
CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1 (EC 2.7.1.78) (Polyadenylation factor Clp1) (Polynucleotide kinase Clp1) (Pre-mRNA cleavage complex II protein Clp1)	5	UniProt NCBI
PCF11	Pre-mRNA cleavage complex 2 protein Pcf11 (Pre-mRNA cleavage complex II protein Pcf11)	5	UniProt NCBI
TSEN2	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	5	UniProt NCBI
TSEN34	tRNA-splicing endonuclease subunit Sen34 (EC 4.6.1.16) (Leukocyte receptor cluster member 5) (tRNA-intron endonuclease Sen34) (HsSen34)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:5283	9.61159511016e-12	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA splicing endonuclease
CORUM:5284	7.02338504734e-09	0.428571428571	TSEN54 CLP1 TSEN2	RNA endonuclease (SEN2deltaEx8, SEN54, CLP1)
GO:0006388	3.03561565333e-07	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA splicing, via endonucleolytic cleavage and ligation
GO:0000394	4.5526752727e-07	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	RNA splicing, via endonucleolytic cleavage and ligation
HP:0006850	1.13970496893e-06	0.428571428571	TSEN54 TSEN34 TSEN2	Hypoplasia of the ventral pons
HP:0012765	1.13970496893e-06	0.428571428571	TSEN54 TSEN34 TSEN2	Widened cerebellar subarachnoid space
REAC:R-HSA-6784531	1.20724098212e-06	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA processing in the nucleus
HP:0200049	3.18986349491e-06	0.428571428571	TSEN54 TSEN34 TSEN2	Upper limb hypertonia
GO:0000379	3.36420143768e-06	0.428571428571	TSEN54 TSEN34 TSEN2	tRNA-type intron splice site recognition and cleavage
GO:0000214	3.36420143768e-06	0.428571428571	TSEN54 CLP1 TSEN2	tRNA-intron endonuclease complex
HP:0003558	9.39291573892e-06	0.428571428571	TSEN54 TSEN34 TSEN2	Viral infection-induced rhabdomyolysis
HP:0031162	1.2521315519e-05	0.428571428571	TSEN54 TSEN34 TSEN2	Impaired oropharyngeal swallow response
REAC:R-HSA-72306	1.32285423695e-05	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA processing
HP:0000253	2.83131938786e-05	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Progressive microcephaly
HP:0002268	3.8662516416e-05	0.428571428571	TSEN54 TSEN34 TSEN2	Paroxysmal dystonia
HP:0011171	7.5557211355e-05	0.428571428571	TSEN54 TSEN34 TSEN2	Simple febrile seizure
HP:0002509	0.000247708003656	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Limb hypertonia
HP:0100704	0.000254794140473	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Cerebral visual impairment
HP:0006895	0.000309191477582	0.428571428571	TSEN54 TSEN34 TSEN2	Lower limb hypertonia
HP:0200136	0.000517268544057	0.428571428571	TSEN54 TSEN34 TSEN2	Oral-pharyngeal dysphagia
HP:0012704	0.000517268544057	0.428571428571	TSEN54 TSEN34 TSEN2	Widened subarachnoid space
HP:0003201	0.000517268544057	0.428571428571	TSEN54 TSEN34 TSEN2	Rhabdomyolysis
HP:0025190	0.000559094255334	0.428571428571	TSEN54 TSEN34 TSEN2	Bilateral tonic-clonic seizure with generalized onset
HP:0006989	0.000603109236937	0.428571428571	TSEN54 TSEN34 TSEN2	Dysplastic corpus callosum
HP:0005484	0.000613260790757	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Secondary microcephaly
HP:0009062	0.000649368697164	0.428571428571	TSEN54 TSEN34 TSEN2	Infantile axial hypotonia
REAC:R-HSA-8953854	0.000832722936992	0.714285714286	TSEN54 TSEN34 CLP1 TSEN2 PCF11	Metabolism of RNA
HP:0007598	0.00148002522626	0.428571428571	TSEN54 TSEN34 TSEN2	Bilateral single transverse palmar creases
CORUM:1141	0.00159705726664	0.285714285714	PCF11 CLP1	CF IIAm complex (Cleavage factor IIAm complex)
HP:0002363	0.00223303835962	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Abnormal brainstem morphology
HP:0007308	0.00249743559672	0.285714285714	TSEN54 TSEN2	Extrapyramidal dyskinesia
HP:0008936	0.00389963758633	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Axial hypotonia
HP:0012703	0.00394880725781	0.428571428571	TSEN54 TSEN34 TSEN2	Abnormal subarachnoid space morphology
HP:0007362	0.00427148998932	0.428571428571	TSEN54 TSEN34 TSEN2	Aplasia/Hypoplasia of the brainstem
HP:0012110	0.00427148998932	0.428571428571	TSEN54 TSEN34 TSEN2	Hypoplasia of the pons
HP:0002365	0.00427148998932	0.428571428571	TSEN54 TSEN34 TSEN2	Hypoplasia of the brainstem
GO:0008033	0.00582419192488	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA processing
HP:0011471	0.00594034849588	0.428571428571	TSEN54 TSEN34 TSEN2	Gastrostomy tube feeding in infancy
REAC:R-HSA-77595	0.0064914715634	0.285714285714	PCF11 CLP1	Processing of Intronless Pre-mRNAs
HP:0002536	0.00826624446399	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Abnormal cortical gyration
HP:0007361	0.00850471620716	0.428571428571	TSEN54 TSEN34 TSEN2	Abnormal pons morphology
GO:0000213	0.00983221512175	0.285714285714	TSEN2 TSEN34	tRNA-intron endonuclease activity
HP:0001266	0.010170078975	0.428571428571	TSEN54 TSEN34 TSEN2	Choreoathetosis
REAC:R-HSA-75067	0.0133002920771	0.285714285714	PCF11 CLP1	Processing of Capped Intronless Pre-mRNA
HP:0032894	0.0137578169218	0.428571428571	TSEN54 TSEN34 TSEN2	Seizure precipitated by febrile infection
HP:0032892	0.0137578169218	0.428571428571	TSEN54 TSEN34 TSEN2	Infection-related seizure
HP:0002373	0.0137578169218	0.428571428571	TSEN54 TSEN34 TSEN2	Febrile seizure (within the age range of 3 months to 6 years)
GO:1902555	0.0150353457168	0.428571428571	TSEN54 CLP1 TSEN2	endoribonuclease complex
HP:0002123	0.0164273557067	0.428571428571	TSEN54 TSEN34 TSEN2	Generalized myoclonic seizure
HP:0002079	0.0174244995856	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Hypoplasia of the corpus callosum
HP:0002033	0.0176688864012	0.428571428571	TSEN54 TSEN34 TSEN2	Poor suck
HP:0002269	0.0186188605393	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Abnormality of neuronal migration
HP:0012469	0.0208033613994	0.428571428571	TSEN54 TSEN34 TSEN2	Infantile spasms
GO:1905348	0.0218744047191	0.428571428571	TSEN54 CLP1 TSEN2	endonuclease complex
HP:0002020	0.0219683118616	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	Gastroesophageal reflux
HP:0000290	0.0271846378781	0.714285714286	TSEN54 TSEN34 AMMECR1 TSEN2 CLP1	Abnormality of the forehead
HP:0002305	0.0281302035428	0.428571428571	TSEN54 TSEN34 TSEN2	Athetosis
HP:0002350	0.0298941171867	0.428571428571	TSEN54 TSEN34 TSEN2	Cerebellar cyst
GO:0006399	0.0361823866547	0.571428571429	TSEN54 TSEN34 CLP1 TSEN2	tRNA metabolic process
KEGG:03015	0.0411825364664	0.285714285714	PCF11 CLP1	mRNA surveillance pathway
HP:0032677	0.0412791464602	0.428571428571	TSEN54 TSEN34 TSEN2	Generalized-onset motor seizure
HP:0000340	0.0420255647459	0.428571428571	TSEN54 TSEN34 TSEN2	Sloping forehead
HP:0011097	0.0466914108174	0.428571428571	TSEN54 TSEN34 TSEN2	Epileptic spasm

Edges

Protein 1	Protein 2	Score	ProteomeHD	Interface Overlap	Evidence
CLP1	TSEN2	0.999	0.166		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN34	0.999	0.108		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN2	TSEN54	0.999	0.116	structurally_consistent (dimer)	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
CLP1	TSEN54	0.999	0.124	structurally_consistent (dimer)	bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
CLP1	TSEN34	0.998	0.12		bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only
CLP1	PCF11	0.997	0.27	structurally_consistent (dimer)	bioplex3_HEK293 bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction
CLP1	AMMECR1	0.981	0.11		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
TSEN34	TSEN54	0.971	0.156		bioplex_WMM bioplex3_WMM WMM_only
PHLDA2	CLP1	0.952	0.062		hein_WMM bioplex3_WMM bioplex3_HCT116 WMM_only
TSEN54	AMMECR1	0.907	0.104		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116
PCF11	TSEN54	0.287	0.134	mutually_exclusive (Q92989)	bioplex3_WMM WMM_only
PCF11	TSEN34	0.215	0.056		bioplex3_WMM youn_WMM WMM_only
PCF11	TSEN2	0.209	0.09		bioplex3_WMM WMM_only
PHLDA2	PCF11	0.135	0.058		bioplex3_WMM WMM_only
PHLDA2	TSEN2	0.122	0.062		bioplex3_WMM WMM_only
PHLDA2	TSEN54	0.069	0.08		bioplex3_WMM WMM_only
PHLDA2	TSEN34	0.063	0.064		bioplex3_WMM WMM_only
TSEN2	AMMECR1	0.061	0.152		bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSEN54	huMAP3_04582.1 huMAP3_06042.1 huMAP3_07243.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
PHLDA2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_11956.1 huMAP3_13483.1 huMAP3_13693.1 huMAP3_14586.1 huMAP3_14839.1 huMAP3_14984.1
AMMECR1	huMAP3_04582.1 huMAP3_08573.1 huMAP3_08812.1 huMAP3_10697.1 huMAP3_11762.1 huMAP3_13483.1 huMAP3_13511.1 huMAP3_14586.1 huMAP3_14839.1
CLP1	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_14586.1 huMAP3_14839.1
PCF11	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_12111.1 huMAP3_13730.1 huMAP3_14483.1 huMAP3_14586.1
TSEN2	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1
TSEN34	huMAP3_02940.1 huMAP3_04582.1 huMAP3_06042.1 huMAP3_10697.1 huMAP3_13483.1 huMAP3_13865.1 huMAP3_14586.1 huMAP3_14839.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04582.1

Complex Portal: CPX-13768