hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04592.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| STK4 | Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)] | 5 | UniProt NCBI |
| STK3 | Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)] | 5 | UniProt NCBI |
| RASSF6 | Ras association domain-containing protein 6 | 4 | UniProt NCBI |
| RASSF2 | Ras association domain-containing protein 2 | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04392 | 8.91489558656e-07 | 0.75 | RASSF2 STK3 RASSF6 | Hippo signaling pathway - multiple species |
| CORUM:6716 | 1.53774525569e-05 | 0.5 | STK4 STK3 | DLG5-MST1-MST2 complex |
| REAC:R-HSA-2028269 | 0.00175047124894 | 0.5 | STK4 STK3 | Signaling by Hippo |
| WP:WP5087 | 0.0029183957539 | 0.75 | RASSF2 STK3 RASSF6 | Pleural mesothelioma |
| KEGG:04390 | 0.02620193588 | 0.5 | STK3 RASSF6 | Hippo signaling pathway |
| CORUM:6403 | 0.049938562206 | 0.25 | STK4 | MST1-SAV1 complex |
| CORUM:6404 | 0.049938562206 | 0.25 | STK3 | MST2-SAV1 complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| STK4 | RASSF2 | 0.999 | 0.086 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| STK4 | STK3 | 0.999 | 0.266 | hein_WMM bioplex_WMM bioplex3_WMM boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| STK3 | RASSF2 | 0.999 | 0.108 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 gupta_WMM |
| STK4 | RASSF6 | 0.987 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| STK3 | RASSF6 | 0.985 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| STK4 | huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1 |
| STK3 | huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1 |
| RASSF6 | huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1 huMAP3_13091.1 |
| RASSF2 | huMAP3_04592.1 huMAP3_11472.1 huMAP3_12772.1 |