hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04593.1
Complex Portal: CPX-19841
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CEP152 | Centrosomal protein of 152 kDa (Cep152) | 5 | UniProt NCBI |
| CEP63 | Centrosomal protein of 63 kDa (Cep63) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0098535 | 0.00140460216025 | 1.0 | CEP152 CEP63 | de novo centriole assembly involved in multi-ciliated epithelial cell differentiation |
| HP:0007333 | 0.00215303980768 | 1.0 | CEP152 CEP63 | Hypoplasia of the frontal lobes |
| GO:0097742 | 0.0028092043205 | 1.0 | CEP152 CEP63 | de novo centriole assembly |
| REAC:R-HSA-380259 | 0.00366529395832 | 1.0 | CEP152 CEP63 | Loss of Nlp from mitotic centrosomes |
| REAC:R-HSA-380284 | 0.00366529395832 | 1.0 | CEP152 CEP63 | Loss of proteins required for interphase microtubule organization from the centrosome |
| REAC:R-HSA-8854518 | 0.00400875507049 | 1.0 | CEP152 CEP63 | AURKA Activation by TPX2 |
| HP:0006872 | 0.00507502240382 | 1.0 | CEP152 CEP63 | Cerebral hypoplasia |
| REAC:R-HSA-380287 | 0.00513141154164 | 1.0 | CEP152 CEP63 | Centrosome maturation |
| REAC:R-HSA-380270 | 0.00513141154164 | 1.0 | CEP152 CEP63 | Recruitment of mitotic centrosome proteins and complexes |
| REAC:R-HSA-2565942 | 0.00581491624249 | 1.0 | CEP152 CEP63 | Regulation of PLK1 Activity at G2/M Transition |
| REAC:R-HSA-380320 | 0.00684359081728 | 1.0 | CEP152 CEP63 | Recruitment of NuMA to mitotic centrosomes |
| GO:1903251 | 0.00702301080125 | 1.0 | CEP152 CEP63 | multi-ciliated epithelial cell differentiation |
| REAC:R-HSA-5620912 | 0.00731008277561 | 1.0 | CEP152 CEP63 | Anchoring of the basal body to the plasma membrane |
| HP:0003103 | 0.00898125176919 | 1.0 | CEP152 CEP63 | Abnormal cortical bone morphology |
| HP:0000122 | 0.0119134869358 | 1.0 | CEP152 CEP63 | Unilateral renal agenesis |
| HP:0002282 | 0.0224018665704 | 1.0 | CEP152 CEP63 | Gray matter heterotopia |
| REAC:R-HSA-69275 | 0.0303578612883 | 1.0 | CEP152 CEP63 | G2/M Transition |
| REAC:R-HSA-5617833 | 0.0303578612883 | 1.0 | CEP152 CEP63 | Cilium Assembly |
| REAC:R-HSA-453274 | 0.0310054819924 | 1.0 | CEP152 CEP63 | Mitotic G2-G2/M phases |
| REAC:R-HSA-68877 | 0.0323212285415 | 1.0 | CEP152 CEP63 | Mitotic Prometaphase |
| HP:0001302 | 0.0376816141579 | 1.0 | CEP152 CEP63 | Pachygyria |
| HP:0000340 | 0.0473702932925 | 1.0 | CEP152 CEP63 | Sloping forehead |
| HP:0001339 | 0.0479410197177 | 1.0 | CEP152 CEP63 | Lissencephaly |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| CEP152 | CEP63 | 0.996 | 0.112 | hein_WMM bioplex3_HEK293 bioplex3_WMM youn_WMM hein () gupta_WMM gupta () bioplex_WMM |
Related Complexes
| Genename | Complexes |
|---|---|
| CEP152 | huMAP3_04593.1 huMAP3_12566.1 |
| CEP63 | huMAP3_04593.1 |