hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04642.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| GATC | Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (Glu-AdT subunit C) (EC 6.3.5.-) (Protein 15E1.2) | 5 | UniProt NCBI |
| QRSL1 | Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (Glu-AdT subunit A) (EC 6.3.5.7) (Glutaminyl-tRNA synthase-like protein 1) | 5 | UniProt NCBI |
| GATB | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (Glu-AdT subunit B) (EC 6.3.5.-) (Cytochrome c oxidase assembly factor PET112 homolog) | 5 | UniProt NCBI |
| COQ6 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (EC 1.14.13.-) (Coenzyme Q10 monooxygenase 6) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6959 | 7.01606139244e-10 | 0.75 | GATC QRSL1 GATB | GATB-GATC-QRSL1 complex |
| GO:0050567 | 3.84480164306e-07 | 0.75 | GATC QRSL1 GATB | glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity |
| GO:0030956 | 3.84480164306e-07 | 0.75 | GATC QRSL1 GATB | glutamyl-tRNA(Gln) amidotransferase complex |
| GO:0070681 | 3.84480164306e-07 | 0.75 | GATC QRSL1 GATB | glutaminyl-tRNAGln biosynthesis via transamidation |
| KEGG:00970 | 4.22779284136e-06 | 0.75 | GATC QRSL1 GATB | Aminoacyl-tRNA biosynthesis |
| HP:0008163 | 1.18865274487e-05 | 0.75 | GATC QRSL1 GATB | Decreased circulating cortisol level |
| GO:0016884 | 3.22863876272e-05 | 0.75 | GATC QRSL1 GATB | carbon-nitrogen ligase activity, with glutamine as amido-N-donor |
| HP:0008207 | 6.93277073106e-05 | 0.75 | GATC QRSL1 GATB | Primary adrenal insufficiency |
| HP:0011731 | 8.41302083589e-05 | 0.75 | GATC QRSL1 GATB | Abnormality of circulating cortisol level |
| HP:0012111 | 8.9495616948e-05 | 0.75 | GATC QRSL1 GATB | Abnormality of circulating glucocorticoid level |
| HP:0001790 | 0.00014837070207 | 0.75 | GATC QRSL1 GATB | Nonimmune hydrops fetalis |
| HP:0000846 | 0.000320567621517 | 0.75 | GATC QRSL1 GATB | Adrenal insufficiency |
| HP:0011733 | 0.000805317802436 | 0.75 | GATC QRSL1 GATB | Abnormality of adrenal physiology |
| HP:0001789 | 0.000955670327393 | 0.75 | GATC QRSL1 GATB | Hydrops fetalis |
| HP:0001622 | 0.00216847712216 | 0.75 | GATC QRSL1 GATB | Premature birth |
| KEGG:01100 | 0.00275730008049 | 1.0 | COQ6 GATC QRSL1 GATB | Metabolic pathways |
| HP:0000834 | 0.00365047696464 | 0.75 | GATC QRSL1 GATB | Abnormality of the adrenal glands |
| GO:0016879 | 0.0037914498893 | 0.75 | GATC QRSL1 GATB | ligase activity, forming carbon-nitrogen bonds |
| GO:0043038 | 0.00409056451107 | 0.75 | GATC QRSL1 GATB | amino acid activation |
| GO:0043039 | 0.00409056451107 | 0.75 | GATC QRSL1 GATB | tRNA aminoacylation |
| HP:0003128 | 0.00412165152512 | 0.75 | GATC QRSL1 GATB | Lactic acidosis |
| HP:0001943 | 0.00814145236404 | 0.75 | GATC QRSL1 GATB | Hypoglycemia |
| HP:0003236 | 0.0129286027945 | 0.75 | GATC QRSL1 GATB | Elevated circulating creatine kinase concentration |
| HP:0034058 | 0.0133827811636 | 0.75 | GATC QRSL1 GATB | Abnormal fetal morphology |
| HP:0011015 | 0.0149729444549 | 0.75 | GATC QRSL1 GATB | Abnormal blood glucose concentration |
| HP:0040081 | 0.0151385225595 | 0.75 | GATC QRSL1 GATB | Abnormal circulating creatine kinase concentration |
| HP:0011021 | 0.0156425362492 | 0.75 | GATC QRSL1 GATB | Abnormality of circulating enzyme level |
| HP:0000818 | 0.0230269631822 | 1.0 | COQ6 GATC QRSL1 GATB | Abnormality of the endocrine system |
| HP:0011924 | 0.0234332085093 | 0.5 | GATC QRSL1 | Decreased activity of mitochondrial complex III |
| HP:0003117 | 0.030773933346 | 0.75 | GATC QRSL1 GATB | Abnormal circulating hormone concentration |
| HP:0001941 | 0.0337929626939 | 0.75 | GATC QRSL1 GATB | Acidosis |
| HP:0000365 | 0.0366506194199 | 1.0 | COQ6 GATC QRSL1 GATB | Hearing impairment |
| HP:0000364 | 0.0392063646668 | 1.0 | COQ6 GATC QRSL1 GATB | Hearing abnormality |
| HP:0004360 | 0.040406598238 | 0.75 | GATC QRSL1 GATB | Abnormality of acid-base homeostasis |
| HP:0031704 | 0.0464502255589 | 1.0 | COQ6 GATC QRSL1 GATB | Abnormal ear physiology |
| HP:0008347 | 0.049422876951 | 0.5 | GATC QRSL1 | Decreased activity of mitochondrial complex IV |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GATC | QRSL1 | 1.0 | 0.68 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| GATC | GATB | 0.999 | 0.764 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| QRSL1 | GATB | 0.999 | 0.296 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| QRSL1 | COQ6 | 0.99 | 0.014 | bioplex3_WMM bioplex3_HCT116 WMM_only |
| COQ6 | GATB | 0.613 | 0.028 | bioplex3_WMM WMM_only |
| GATC | COQ6 | 0.22 | 0.044 | bioplex3_WMM WMM_only |
Related Complexes