hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04647.1
Complex Portal: CPX-24312
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ATF2 | Cyclic AMP-dependent transcription factor ATF-2 (cAMP-dependent transcription factor ATF-2) (Activating transcription factor 2) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (HB16) (cAMP response element-binding protein CRE-BP1) | 5 | UniProt NCBI |
| CREB5 | Cyclic AMP-responsive element-binding protein 5 (CREB-5) (cAMP-responsive element-binding protein 5) (cAMP-response element-binding protein A) (CRE-BPa) | 5 | UniProt NCBI |
| JUNB | Transcription factor JunB (Transcription factor AP-1 subunit JunB) | 5 | UniProt NCBI |
| JUND | Transcription factor JunD (Transcription factor AP-1 subunit JunD) | 5 | UniProt NCBI |
| ATF7 | Cyclic AMP-dependent transcription factor ATF-7 (cAMP-dependent transcription factor ATF-7) (Activating transcription factor 7) (Transcription factor ATF-A) | 5 | UniProt NCBI |
| ATF3 | Cyclic AMP-dependent transcription factor ATF-3 (cAMP-dependent transcription factor ATF-3) (Activating transcription factor 3) | 5 | UniProt NCBI |
| JUN | Transcription factor Jun (Activator protein 1) (AP1) (Proto-oncogene c-Jun) (Transcription factor AP-1 subunit Jun) (V-jun avian sarcoma virus 17 oncogene homolog) (p39) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6092 | 1.36501667663e-05 | 0.4 | JUN ATF3 | c-Jun-ATF3 complex |
| GO:0035497 | 5.37995977657e-05 | 0.6 | CREB5 ATF7 JUN | cAMP response element binding |
| WP:WP366 | 0.000326721949415 | 0.6 | JUND ATF3 JUN | TGF beta signaling pathway |
| WP:WP516 | 0.00089796435942 | 0.4 | JUND ATF3 | Hypertrophy model |
| KEGG:05030 | 0.00370756607295 | 0.4 | CREB5 JUN | Cocaine addiction |
| WP:WP2873 | 0.00389862536801 | 0.4 | JUND JUN | Aryl hydrocarbon receptor pathway |
| WP:WP5373 | 0.00433647105223 | 0.4 | JUND JUN | Role of hypoxia angiogenesis and FGF pathway in OA chondrocyte hypertrophy |
| KEGG:05031 | 0.00720037844657 | 0.4 | CREB5 JUN | Amphetamine addiction |
| GO:0090575 | 0.00929711903114 | 0.8 | JUN JUND ATF7 ATF3 | RNA polymerase II transcription regulator complex |
| KEGG:04657 | 0.0131645270498 | 0.4 | JUND JUN | IL-17 signaling pathway |
| KEGG:04928 | 0.0152980219787 | 0.4 | CREB5 JUND | Parathyroid hormone synthesis, secretion and action |
| KEGG:04915 | 0.0187947263105 | 0.4 | CREB5 JUN | Estrogen signaling pathway |
| GO:0000978 | 0.0192772113985 | 1.0 | JUN CREB5 ATF3 ATF7 JUND | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| WP:WP4258 | 0.0197951791935 | 0.4 | JUN ATF3 | lncRNA in canonical Wnt signaling and colorectal cancer |
| KEGG:04668 | 0.0200391528804 | 0.4 | CREB5 JUN | TNF signaling pathway |
| GO:0000987 | 0.0213878677719 | 1.0 | JUN CREB5 ATF3 ATF7 JUND | cis-regulatory region sequence-specific DNA binding |
| KEGG:04926 | 0.0258857078716 | 0.4 | CREB5 JUN | Relaxin signaling pathway |
| GO:0035976 | 0.0280843539964 | 0.4 | JUND JUN | transcription factor AP-1 complex |
| KEGG:04380 | 0.0293384756517 | 0.4 | JUND JUN | Osteoclast differentiation |
| GO:0000981 | 0.0378314216665 | 1.0 | JUN CREB5 ATF3 ATF7 JUND | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0000977 | 0.0435745197674 | 1.0 | JUN CREB5 ATF3 ATF7 JUND | RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| KEGG:05161 | 0.0484667159694 | 0.4 | CREB5 JUN | Hepatitis B |
| WP:WP289 | 0.0492060648012 | 0.4 | JUN ATF3 | Myometrial relaxation and contraction pathways |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| JUNB | ATF7 | 1.0 | 0.136 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATF2 | JUNB | 1.0 | 0.094 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| JUNB | JUN | 1.0 | 0.326120260424 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CREB5 | JUN | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | ||
| ATF7 | JUN | 0.999 | 0.444 | hein_WMM bioplex_WMM bioplex3_WMM hein () | |
| ATF2 | JUN | 0.999 | 0.376827743417 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () | |
| CREB5 | JUNB | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| JUND | JUN | 0.998 | 0.45 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| JUND | ATF7 | 0.998 | 0.126 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| JUNB | JUND | 0.998 | 0.076 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| ATF2 | JUND | 0.998 | 0.104 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| CREB5 | JUND | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ATF2 | ATF7 | 0.997 | 0.244 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ATF3 | JUN | 0.996 | 0.261319148936 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM hein () | |
| CREB5 | ATF7 | 0.995 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| ATF2 | CREB5 | 0.995 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | ||
| CREB5 | ATF3 | 0.986 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | ||
| JUNB | ATF3 | 0.982 | 0.1444 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| ATF2 | ATF3 | 0.972 | 0.08 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| ATF7 | ATF3 | 0.971 | 0.092 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| JUND | ATF3 | 0.164 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes