hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04650.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ACTR6 | Actin-related protein 6 (hArp6) (hARPX) | 5 | UniProt NCBI |
| ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E (LANP-like protein) (LANP-L) | 5 | UniProt NCBI |
| DMAP1 | DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1) | 5 | UniProt NCBI |
| BRD8 | Bromodomain-containing protein 8 (Skeletal muscle abundant protein) (Skeletal muscle abundant protein 2) (Thyroid hormone receptor coactivating protein of 120 kDa) (TrCP120) (p120) | 5 | UniProt NCBI |
| KAT5 | Histone acetyltransferase KAT5 (EC 2.3.1.48) (60 kDa Tat-interactive protein) (Tip60) (Histone acetyltransferase HTATIP) (HIV-1 Tat interactive protein) (Lysine acetyltransferase 5) (Protein 2-hydroxyisobutyryltransferase KAT5) (EC 2.3.1.-) (Protein acetyltransferase KAT5) (EC 2.3.1.-) (Protein crotonyltransferase KAT5) (EC 2.3.1.-) (cPLA(2)-interacting protein) | 5 | UniProt NCBI |
| VPS72 | Vacuolar protein sorting-associated protein 72 homolog (Protein YL-1) (Transcription factor-like 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0000812 | 6.95001783241e-11 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | Swr1 complex |
| CORUM:529 | 1.74547730991e-09 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | NuA4/Tip60-HAT complex |
| GO:0097346 | 4.35607377152e-09 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | INO80-type complex |
| KEGG:03082 | 5.11422692975e-09 | 0.833333333333 | BRD8 VPS72 ACTR6 KAT5 DMAP1 | ATP-dependent chromatin remodeling |
| GO:0000118 | 4.10538278334e-07 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | histone deacetylase complex |
| CORUM:799 | 5.6068011168e-07 | 0.5 | VPS72 DMAP1 BRD8 | DMAP1-associated complex |
| CORUM:2856 | 5.6068011168e-07 | 0.5 | DMAP1 KAT5 BRD8 | NuA4/Tip60 HAT complex |
| GO:0000786 | 1.21248017264e-06 | 0.833333333333 | BRD8 VPS72 ACTR6 KAT5 DMAP1 | nucleosome |
| CORUM:2857 | 1.69968198401e-06 | 0.5 | DMAP1 KAT5 BRD8 | NuA4/Tip60 HAT complex |
| CORUM:798 | 2.12427516715e-06 | 0.5 | DMAP1 KAT5 BRD8 | NuA4/Tip60-HAT complex A |
| CORUM:528 | 2.12427516715e-06 | 0.5 | DMAP1 KAT5 BRD8 | NuA4/Tip60-HAT complex |
| GO:0070603 | 2.64367621138e-06 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | SWI/SNF superfamily-type complex |
| GO:0035267 | 8.06004189332e-06 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | NuA4 histone acetyltransferase complex |
| GO:0043189 | 8.06004189332e-06 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | H4/H2A histone acetyltransferase complex |
| REAC:R-HSA-3214847 | 1.57574096812e-05 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | HATs acetylate histones |
| GO:1905168 | 1.60994442835e-05 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | positive regulation of double-strand break repair via homologous recombination |
| GO:1904949 | 2.15565541126e-05 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | ATPase complex |
| GO:1902562 | 4.39939518846e-05 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | H4 histone acetyltransferase complex |
| GO:0000228 | 6.51851913963e-05 | 0.833333333333 | BRD8 DMAP1 ACTR6 KAT5 ANP32E | nuclear chromosome |
| GO:0045911 | 7.00676910422e-05 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | positive regulation of DNA recombination |
| REAC:R-HSA-3247509 | 0.000224381796412 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | Chromatin modifying enzymes |
| REAC:R-HSA-4839726 | 0.000224381796412 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | Chromatin organization |
| GO:0010569 | 0.000265438603659 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | regulation of double-strand break repair via homologous recombination |
| CORUM:787 | 0.000477929626316 | 0.333333333333 | DMAP1 KAT5 | NuA4/Tip60-HAT complex B |
| GO:2000781 | 0.000558442198281 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | positive regulation of double-strand break repair |
| CORUM:304 | 0.000767820823501 | 0.333333333333 | ACTR6 VPS72 | SRCAP-associated chromatin remodeling complex |
| GO:0000123 | 0.000911926366134 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | histone acetyltransferase complex |
| GO:0031248 | 0.00141109188279 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | protein acetyltransferase complex |
| GO:1902493 | 0.00141109188279 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | acetyltransferase complex |
| GO:0000018 | 0.00165931249978 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | regulation of DNA recombination |
| GO:0045739 | 0.0032011543781 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | positive regulation of DNA repair |
| GO:2000779 | 0.0032011543781 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | regulation of double-strand break repair |
| GO:0000785 | 0.00426486918429 | 1.0 | ANP32E BRD8 VPS72 ACTR6 KAT5 DMAP1 | chromatin |
| GO:0032993 | 0.00607918081447 | 1.0 | ANP32E BRD8 VPS72 ACTR6 KAT5 DMAP1 | protein-DNA complex |
| GO:0000724 | 0.00969847453123 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | double-strand break repair via homologous recombination |
| GO:0000725 | 0.0107239945371 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | recombinational repair |
| GO:0006282 | 0.0230417949307 | 0.666666666667 | VPS72 DMAP1 KAT5 BRD8 | regulation of DNA repair |
| GO:0005694 | 0.0377686998201 | 1.0 | ANP32E BRD8 VPS72 ACTR6 KAT5 DMAP1 | chromosome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| DMAP1 | VPS72 | 1.0 | 0.264 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM Malo bioplex3_HCT116 fraction |
| ACTR6 | KAT5 | 0.999 | 0.118 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ACTR6 | BRD8 | 0.999 | 0.132 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| ACTR6 | VPS72 | 0.999 | 0.396 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only |
| KAT5 | VPS72 | 0.999 | 0.104 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| BRD8 | VPS72 | 0.999 | 0.308 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| DMAP1 | BRD8 | 0.998 | 0.222 | hein_WMM bioplex3_HEK293 bioplex_WMM Guru bioplex3_WMM youn_WMM bioplex3_HCT116 fraction |
| ACTR6 | DMAP1 | 0.998 | 0.18 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| BRD8 | KAT5 | 0.998 | 0.132 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| ANP32E | VPS72 | 0.997 | 0.058 | hein_WMM bioplex_WMM Guru bioplex3_WMM youn_WMM fraction |
| DMAP1 | KAT5 | 0.992 | 0.168 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 |
| ANP32E | DMAP1 | 0.958 | 0.052 | bioplex_WMM Guru bioplex3_WMM youn_WMM gupta_WMM fraction |
| ANP32E | KAT5 | 0.854 | 0.169666666667 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| ACTR6 | ANP32E | 0.795 | 0.074 | bioplex_WMM bioplex3_WMM fraction |
| ANP32E | BRD8 | 0.695 | 0.04 | bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 WMM_only |
Related Complexes