hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04679.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| NME3 | Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3) | 5 | UniProt NCBI |
| NDUFA4 | Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit) | 5 | UniProt NCBI |
| NME2 | Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (EC 2.7.4.6) (C-myc purine-binding transcription factor PUF) (Histidine protein kinase NDKB) (EC 2.7.13.3) (nm23-H2) | 5 | UniProt NCBI |
| NME4 | Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4) | 5 | UniProt NCBI |
| NME1 | Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-499943 | 2.4825378684e-06 | 0.75 | NME2 NME3 NME4 | Interconversion of nucleotide di- and triphosphates |
| KEGG:00240 | 4.86072516083e-06 | 0.75 | NME2 NME3 NME4 | Pyrimidine metabolism |
| KEGG:00983 | 1.63910874597e-05 | 0.75 | NME2 NME3 NME4 | Drug metabolism - other enzymes |
| KEGG:01232 | 1.8726845031e-05 | 0.75 | NME2 NME3 NME4 | Nucleotide metabolism |
| KEGG:00230 | 5.19578118732e-05 | 0.75 | NME2 NME3 NME4 | Purine metabolism |
| GO:0004550 | 6.34131776058e-05 | 0.75 | NME2 NME3 NME4 | nucleoside diphosphate kinase activity |
| REAC:R-HSA-15869 | 0.000102255107087 | 0.75 | NME2 NME3 NME4 | Metabolism of nucleotides |
| KEGG:01240 | 0.000133691874029 | 0.75 | NME2 NME3 NME4 | Biosynthesis of cofactors |
| GO:0016776 | 0.00112321912057 | 0.75 | NME2 NME3 NME4 | phosphotransferase activity, phosphate group as acceptor |
| GO:0019205 | 0.00229706847948 | 0.75 | NME2 NME3 NME4 | nucleobase-containing compound kinase activity |
| KEGG:01100 | 0.00275730008049 | 1.0 | NME2 NME4 NME3 NDUFA4 | Metabolic pathways |
| HPA:0270363 | 0.0232681464336 | 1.0 | NME2 NME4 NME3 NDUFA4 | kidney; cells in tubules[High] |
| REAC:R-HSA-1430728 | 0.0393174957935 | 1.0 | NME2 NME4 NME3 NDUFA4 | Metabolism |
| HPA:0510113 | 0.0499490020628 | 0.5 | NME2 NME3 | soft tissue 2; chondrocytes[High] |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| NME1 | NME3 | 0.999 | 0.032 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| NME4 | NME3 | 0.998 | 0.12 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NME2 | NME3 | 0.997 | 0.04 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM |
| NME2 | NME1 | 0.996 | 0.94 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM WMM_only |
| NME1 | NME4 | 0.982 | 0.172 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
| NDUFA4 | NME3 | 0.958 | 0.116 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt bioplex3_HCT116 boldt_WMM WMM_only |
| NME2 | NME4 | 0.914 | 0.124 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| NDUFA4 | NME1 | 0.05 | 0.062 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM WMM_only |
| NDUFA4 | NME2 | 0.035 | 0.06 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM boldt gupta_WMM boldt_WMM WMM_only |
| NDUFA4 | NME4 | 0.029 | 0.048 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes