hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04688.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| CCNB3 | G2/mitotic-specific cyclin-B3 | 5 | UniProt NCBI |
| CCNE1 | G1/S-specific cyclin-E1 | 5 | UniProt NCBI |
| CCNE2 | G1/S-specific cyclin-E2 | 5 | UniProt NCBI |
| CCNO | Cyclin-O | 5 | UniProt NCBI |
| FGR | Tyrosine-protein kinase Fgr (EC 2.7.10.2) (Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog) (Proto-oncogene c-Fgr) (p55-Fgr) (p58-Fgr) (p58c-Fgr) | 5 | UniProt NCBI |
| CDKN1A | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016538 | 1.46952249556e-05 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | cyclin-dependent protein serine/threonine kinase regulator activity |
| GO:0000307 | 4.47449753489e-05 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | cyclin-dependent protein kinase holoenzyme complex |
| WP:WP1530 | 5.24101251737e-05 | 0.6 | CDKN1A CCNB3 CCNE2 | miRNA regulation of DNA damage response |
| WP:WP707 | 5.24101251737e-05 | 0.6 | CDKN1A CCNB3 CCNE2 | DNA damage response |
| WP:WP179 | 0.000302523176006 | 0.6 | CDKN1A CCNB3 CCNE2 | Cell cycle |
| KEGG:04218 | 0.000411831232455 | 0.6 | CDKN1A CCNB3 CCNE2 | Cellular senescence |
| KEGG:04110 | 0.000516961308947 | 0.6 | CDKN1A CCNB3 CCNE2 | Cell cycle |
| REAC:R-HSA-6804116 | 0.0011839189519 | 0.4 | CCNE2 CDKN1A | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| GO:1902554 | 0.00130803575944 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | serine/threonine protein kinase complex |
| REAC:R-HSA-9661069 | 0.00206313859056 | 0.4 | CCNE2 CDKN1A | Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) |
| REAC:R-HSA-9659787 | 0.00206313859056 | 0.4 | CCNE2 CDKN1A | Aberrant regulation of mitotic G1/S transition in cancer due to RB1 defects |
| GO:1902911 | 0.00218060317198 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | protein kinase complex |
| GO:0019887 | 0.00480818953079 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | protein kinase regulator activity |
| GO:0019207 | 0.00893796193013 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | kinase regulator activity |
| REAC:R-HSA-9687139 | 0.00900400267976 | 0.4 | CCNE2 CDKN1A | Aberrant regulation of mitotic cell cycle due to RB1 defects |
| KEGG:04115 | 0.00908648748607 | 0.4 | CCNE2 CDKN1A | p53 signaling pathway |
| REAC:R-HSA-9675126 | 0.0100756681589 | 0.4 | CCNE2 CDKN1A | Diseases of mitotic cell cycle |
| WP:WP45 | 0.0117576408425 | 0.4 | CCNE2 CDKN1A | G1 to S cell cycle control |
| REAC:R-HSA-6791312 | 0.0149609318958 | 0.4 | CCNE2 CDKN1A | TP53 Regulates Transcription of Cell Cycle Genes |
| REAC:R-HSA-69236 | 0.0156388304105 | 0.4 | CCNE2 CDKN1A | G1 Phase |
| REAC:R-HSA-69231 | 0.0156388304105 | 0.4 | CCNE2 CDKN1A | Cyclin D associated events in G1 |
| KEGG:05222 | 0.0164241113683 | 0.4 | CCNE2 CDKN1A | Small cell lung cancer |
| KEGG:05215 | 0.0179869923441 | 0.4 | CCNE2 CDKN1A | Prostate cancer |
| WP:WP2446 | 0.0212523049113 | 0.4 | CCNE2 CDKN1A | Retinoblastoma gene in cancer |
| WP:WP4658 | 0.0227605362571 | 0.4 | CCNE2 CDKN1A | Small cell lung cancer |
| REAC:R-HSA-187577 | 0.0266933781073 | 0.4 | CCNE2 CDKN1A | SCF(Skp2)-mediated degradation of p27/p21 |
| KEGG:04068 | 0.028330266578 | 0.4 | CCNB3 CDKN1A | FoxO signaling pathway |
| REAC:R-HSA-69580 | 0.0303866302294 | 0.4 | CCNE2 CDKN1A | p53-Dependent G1/S DNA damage checkpoint |
| REAC:R-HSA-69563 | 0.0303866302294 | 0.4 | CCNE2 CDKN1A | p53-Dependent G1 DNA Damage Response |
| GO:0061695 | 0.0306592465565 | 0.8 | CCNO CDKN1A CCNB3 CCNE2 | transferase complex, transferring phosphorus-containing groups |
| REAC:R-HSA-69615 | 0.0323221445549 | 0.4 | CCNE2 CDKN1A | G1/S DNA Damage Checkpoints |
| REAC:R-HSA-2559586 | 0.0333121022189 | 0.4 | CCNE2 CDKN1A | DNA Damage/Telomere Stress Induced Senescence |
| KEGG:04934 | 0.0346393491085 | 0.4 | CCNE2 CDKN1A | Cushing syndrome |
| KEGG:05226 | 0.0380272112444 | 0.4 | CCNE2 CDKN1A | Gastric cancer |
| WP:WP4284 | 0.0429732972479 | 0.2 | CCNE2 | Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer |
| KEGG:05206 | 0.0484667159694 | 0.4 | CCNE2 CDKN1A | MicroRNAs in cancer |
| KEGG:05161 | 0.0484667159694 | 0.4 | CCNE2 CDKN1A | Hepatitis B |
| CORUM:314 | 0.0498708842806 | 0.2 | CDKN1A | PCNA-p21 complex |
| REAC:R-HSA-69202 | 0.0499330761364 | 0.4 | CCNE2 CDKN1A | Cyclin E associated events during G1/S transition |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CCNE2 | CDKN1A | 0.999 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 | |
| CCNE1 | CDKN1A | 0.999 | 0.156 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCNE1 | CCNE2 | 0.999 | hein_WMM bioplex_WMM bioplex3_WMM WMM_only | |
| CCNO | CDKN1A | 0.996 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| CCNB3 | CDKN1A | 0.991 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| FGR | CDKN1A | 0.981 | 0.138 | bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| CCNO | CCNB3 | 0.902 | bioplex3_WMM WMM_only | |
| FGR | CCNB3 | 0.869 | bioplex3_WMM WMM_only | |
| CCNO | FGR | 0.869 | bioplex3_WMM WMM_only | |
| CCNB3 | CCNE2 | 0.804 | bioplex3_WMM WMM_only | |
| CCNO | CCNE2 | 0.768 | bioplex3_WMM WMM_only | |
| CCNB3 | CCNE1 | 0.561 | bioplex3_WMM WMM_only | |
| CCNO | CCNE1 | 0.455 | bioplex3_WMM WMM_only | |
| FGR | CCNE2 | 0.356 | bioplex3_WMM WMM_only | |
| FGR | CCNE1 | 0.334 | bioplex3_WMM WMM_only |
Related Complexes