hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04698.1
Complex Portal: CPX-13374
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| LAMB3 | Laminin subunit beta-3 (Epiligrin subunit bata) (Kalinin B1 chain) (Kalinin subunit beta) (Laminin B1k chain) (Laminin-5 subunit beta) (Nicein subunit beta) | 5 | UniProt NCBI |
| IDUA | Alpha-L-iduronidase (EC 3.2.1.76) | 5 | UniProt NCBI |
| TOR3A | Torsin-3A (ATP-dependent interferon-responsive protein) (Torsin family 3 member A) | 5 | UniProt NCBI |
| PCSK9 | Proprotein convertase subtilisin/kexin type 9 (EC 3.4.21.-) (Neural apoptosis-regulated convertase 1) (NARC-1) (Proprotein convertase 9) (PC9) (Subtilisin/kexin-like protease PC9) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0001681 | 0.0126114492305 | 0.5 | IDUA PCSK9 | Angina pectoris |
| WP:WP2846 | 0.0248784837172 | 0.25 | PCSK9 | PCSK9 mediated LDL receptor degradation |
| WP:WP3408 | 0.0248784837172 | 0.25 | PCSK9 | Evolocumab mechanism to reduce LDL cholesterol |
| REAC:R-HSA-2206302 | 0.0499436884912 | 0.25 | IDUA | MPS I - Hurler syndrome |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| LAMB3 | TOR3A | 0.978 | 0.02 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCSK9 | TOR3A | 0.968 | 0.036 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| IDUA | TOR3A | 0.965 | 0.062 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| LAMB3 | IDUA | 0.473 | 0.116 | bioplex3_WMM WMM_only | |
| PCSK9 | IDUA | 0.454 | 0.106 | bioplex3_WMM WMM_only | |
| LAMB3 | PCSK9 | 0.443 | 0.12 | bioplex3_WMM WMM_only |
Related Complexes