hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04700.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | 5 | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (EC 3.6.5.-) (G1 to S phase transition protein 2 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 0.000500549133471 | 1.0 | ETF1 GSPT2 | Translation factors |
| KEGG:03015 | 0.000665722898869 | 1.0 | ETF1 GSPT2 | mRNA surveillance pathway |
| GO:0018444 | 0.00140460216025 | 1.0 | ETF1 GSPT2 | translation release factor complex |
| REAC:R-HSA-72764 | 0.00699737937497 | 1.0 | ETF1 GSPT2 | Eukaryotic Translation Termination |
| GO:0003747 | 0.00702301080125 | 1.0 | ETF1 GSPT2 | translation release factor activity |
| GO:0008079 | 0.00702301080125 | 1.0 | ETF1 GSPT2 | translation termination factor activity |
| REAC:R-HSA-975956 | 0.00746899761856 | 1.0 | ETF1 GSPT2 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-975957 | 0.0110061344455 | 1.0 | ETF1 GSPT2 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.0110061344455 | 1.0 | ETF1 GSPT2 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-9010553 | 0.0234014921954 | 1.0 | ETF1 GSPT2 | Regulation of expression of SLITs and ROBOs |
| CORUM:809 | 0.0249718442457 | 0.5 | ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
| GO:0006415 | 0.0365196561665 | 1.0 | ETF1 GSPT2 | translational termination |
| REAC:R-HSA-376176 | 0.0374987766505 | 1.0 | ETF1 GSPT2 | Signaling by ROBO receptors |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| GSPT2 | ETF1 | 0.987 | 0.686 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM |
Related Complexes