hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04702.1
Complex Portal: CPX-17366
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| EIF4EBP2 | Eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2) (eIF4E-binding protein 2) | 5 | UniProt NCBI |
| EIF4EBP1 | Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I) | 5 | UniProt NCBI |
| EIF4E | Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP107 | 1.42815777161e-06 | 1.0 | EIF4EBP1 EIF4EBP2 EIF4E | Translation factors |
| WP:WP516 | 0.000173183276299 | 0.666666666667 | EIF4EBP1 EIF4E | Hypertrophy model |
| WP:WP3879 | 0.000237669979309 | 0.666666666667 | EIF4EBP1 EIF4E | 4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression |
| GO:0031369 | 0.000281151120149 | 1.0 | EIF4EBP1 EIF4EBP2 EIF4E | translation initiation factor binding |
| WP:WP4566 | 0.000927197171072 | 0.666666666667 | EIF4EBP1 EIF4E | Translation inhibitors in chronically activated PDGFRA cells |
| WP:WP585 | 0.00144101964081 | 0.666666666667 | EIF4EBP1 EIF4E | Interferon type I signaling pathways |
| REAC:R-HSA-166208 | 0.00188000535098 | 0.666666666667 | EIF4EBP1 EIF4E | mTORC1-mediated signalling |
| KEGG:01521 | 0.00205509166508 | 0.666666666667 | EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04211 | 0.0024644071062 | 0.666666666667 | EIF4EBP1 EIF4E | Longevity regulating pathway |
| WP:WP2034 | 0.00257262049766 | 0.666666666667 | EIF4EBP1 EIF4E | Leptin signaling pathway |
| WP:WP4674 | 0.00272708951202 | 0.666666666667 | EIF4EBP1 EIF4E | Head and neck squamous cell carcinoma |
| WP:WP4806 | 0.00347772346958 | 0.666666666667 | EIF4EBP1 EIF4E | EGFR tyrosine kinase inhibitor resistance |
| KEGG:04066 | 0.00368672413844 | 0.666666666667 | EIF4EBP1 EIF4E | HIF-1 signaling pathway |
| REAC:R-HSA-165159 | 0.005581186855 | 0.666666666667 | EIF4EBP1 EIF4E | MTOR signalling |
| KEGG:04910 | 0.00597753688328 | 0.666666666667 | EIF4EBP1 EIF4E | Insulin signaling pathway |
| WP:WP4549 | 0.0067573392711 | 0.666666666667 | EIF4EBP2 EIF4E | Fragile X syndrome |
| WP:WP3915 | 0.00725872233472 | 0.666666666667 | EIF4EBP1 EIF4E | Angiopoietin like protein 8 regulatory pathway |
| KEGG:04150 | 0.00824863650471 | 0.666666666667 | EIF4EBP1 EIF4E | mTOR signaling pathway |
| WP:WP2380 | 0.00845205977617 | 0.666666666667 | EIF4EBP1 EIF4E | Brain derived neurotrophic factor BDNF signaling pathway |
| WP:WP481 | 0.011426766529 | 0.666666666667 | EIF4EBP1 EIF4E | Insulin signaling |
| REAC:R-HSA-72662 | 0.0120367347963 | 0.666666666667 | EIF4EBP1 EIF4E | Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| WP:WP5115 | 0.0163374881119 | 0.666666666667 | EIF4EBP1 EIF4E | Network map of SARS CoV 2 signaling pathway |
| GO:0006413 | 0.0180186629002 | 1.0 | EIF4EBP1 EIF4EBP2 EIF4E | translational initiation |
| GO:0045182 | 0.0207446272651 | 1.0 | EIF4EBP1 EIF4EBP2 EIF4E | translation regulator activity |
| KEGG:04151 | 0.0307080825491 | 0.666666666667 | EIF4EBP1 EIF4E | PI3K-Akt signaling pathway |
| WP:WP3932 | 0.0343043102958 | 0.666666666667 | EIF4EBP1 EIF4E | Focal adhesion PI3K Akt mTOR signaling pathway |
| GO:0008190 | 0.0393180950424 | 0.666666666667 | EIF4EBP1 EIF4EBP2 | eukaryotic initiation factor 4E binding |
| WP:WP4172 | 0.0409328508823 | 0.666666666667 | EIF4EBP1 EIF4E | PI3K Akt signaling pathway |
| REAC:R-HSA-72613 | 0.0468187221283 | 0.666666666667 | EIF4EBP1 EIF4E | Eukaryotic Translation Initiation |
| REAC:R-HSA-72737 | 0.0468187221283 | 0.666666666667 | EIF4EBP1 EIF4E | Cap-dependent Translation Initiation |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| EIF4E | EIF4EBP2 | 0.998 | 0.124 |
structurally_consistent (dimer)
|
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4EBP1 | EIF4E | 0.998 | 0.1384 |
mutually_exclusive (A6NMX2)
structurally_consistent (dimer) |
bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 fraction |
| EIF4EBP1 | EIF4EBP2 | 0.982 | 0.042 |
mutually_exclusive (P06730)
|
bioplex_WMM bioplex3_WMM fraction |
Related Complexes