hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04704.1

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
PDK1	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)	5	UniProt NCBI
PDHX	Pyruvate dehydrogenase protein X component, mitochondrial (Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex) (E3-binding protein) (E3BP) (Lipoyl-containing pyruvate dehydrogenase complex component X) (proX)	5	UniProt NCBI
PDK3	[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 3)	5	UniProt NCBI
PDHA1	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (EC 1.2.4.1) (PDHE1-A type I)	5	UniProt NCBI
STAT5B	Signal transducer and activator of transcription 5B	5	UniProt NCBI
PDHB	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHE1-B) (EC 1.2.4.1)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-204174	7.76907848915e-10	0.8	PDHA1 PDK1 PDK3 PDHX	Regulation of pyruvate dehydrogenase (PDH) complex
REAC:R-HSA-70268	1.16894660556e-08	0.8	PDHA1 PDK1 PDK3 PDHX	Pyruvate metabolism
GO:0006086	2.76191861336e-08	0.8	PDHA1 PDK1 PDK3 PDHX	acetyl-CoA biosynthetic process from pyruvate
REAC:R-HSA-5362517	2.81603526855e-08	0.8	PDHA1 PDK1 PDK3 PDHX	Signaling by Retinoic Acid
REAC:R-HSA-71406	1.15337100464e-07	0.8	PDHA1 PDK1 PDK3 PDHX	Pyruvate metabolism and Citric Acid (TCA) cycle
GO:0006085	3.12897432326e-07	0.8	PDHA1 PDK1 PDK3 PDHX	acetyl-CoA biosynthetic process
GO:0006084	1.96449993261e-06	0.8	PDHA1 PDK1 PDK3 PDHX	acetyl-CoA metabolic process
GO:0035384	9.69325556185e-06	0.8	PDHA1 PDK1 PDK3 PDHX	thioester biosynthetic process
GO:0071616	9.69325556185e-06	0.8	PDHA1 PDK1 PDK3 PDHX	acyl-CoA biosynthetic process
REAC:R-HSA-1428517	1.3881982562e-05	0.8	PDHA1 PDK1 PDK3 PDHX	The citric acid (TCA) cycle and respiratory electron transport
GO:0033866	2.55378856908e-05	0.8	PDHA1 PDK1 PDK3 PDHX	nucleoside bisphosphate biosynthetic process
GO:0034030	2.55378856908e-05	0.8	PDHA1 PDK1 PDK3 PDHX	ribonucleoside bisphosphate biosynthetic process
GO:0034033	2.55378856908e-05	0.8	PDHA1 PDK1 PDK3 PDHX	purine nucleoside bisphosphate biosynthetic process
GO:0006790	5.97436292687e-05	1.0	PDHA1 PDK1 STAT5B PDK3 PDHX	sulfur compound metabolic process
REAC:R-HSA-9006931	6.37886191161e-05	0.8	PDHA1 PDK1 PDK3 PDHX	Signaling by Nuclear Receptors
GO:0006637	0.000177329500288	0.8	PDHA1 PDK1 PDK3 PDHX	acyl-CoA metabolic process
GO:0035383	0.000177329500288	0.8	PDHA1 PDK1 PDK3 PDHX	thioester metabolic process
WP:WP5050	0.000264396631677	0.4	PDK1 PDHA1	TCA cycle in senescence
GO:0006090	0.000305379790485	0.8	PDHA1 PDK1 PDK3 PDHX	pyruvate metabolic process
GO:0033875	0.000453524093368	0.8	PDHA1 PDK1 PDK3 PDHX	ribonucleoside bisphosphate metabolic process
GO:0034032	0.000453524093368	0.8	PDHA1 PDK1 PDK3 PDHX	purine nucleoside bisphosphate metabolic process
GO:0033865	0.000453524093368	0.8	PDHA1 PDK1 PDK3 PDHX	nucleoside bisphosphate metabolic process
HP:0500231	0.000961529670085	0.4	PDHX PDHA1	Abnormal CSF pyruvate family amino acid concentration
WP:WP4206	0.0011148137474	0.4	PDK1 PDHA1	Hereditary leiomyomatosis and renal cell carcinoma pathway
WP:WP581	0.00135500760343	0.4	PDK1 STAT5B	EPO receptor signaling
GO:0044272	0.00153075920238	0.8	PDHA1 PDK1 PDK3 PDHX	sulfur compound biosynthetic process
HP:0002928	0.00288300984678	0.4	PDHX PDHA1	Decreased activity of the pyruvate dehydrogenase complex
GO:0009152	0.00317794363223	0.8	PDHA1 PDK1 PDK3 PDHX	purine ribonucleotide biosynthetic process
GO:0009260	0.00397811315054	0.8	PDHA1 PDK1 PDK3 PDHX	ribonucleotide biosynthetic process
WP:WP5220	0.00433647105223	0.4	PDHX PDHA1	Metabolic reprogramming in pancreatic cancer
REAC:R-HSA-389661	0.00454605723789	0.4	PDHX PDHA1	Glyoxylate metabolism and glycine degradation
GO:0046390	0.00458954735571	0.8	PDHA1 PDK1 PDK3 PDHX	ribose phosphate biosynthetic process
GO:0097411	0.00468200720083	0.4	PDK1 PDK3	hypoxia-inducible factor-1alpha signaling pathway
GO:0006164	0.00642530322484	0.8	PDHA1 PDK1 PDK3 PDHX	purine nucleotide biosynthetic process
GO:0006082	0.00709889029368	1.0	PDHA1 PDK1 STAT5B PDK3 PDHX	organic acid metabolic process
GO:0072522	0.00714462455018	0.8	PDHA1 PDK1 PDK3 PDHX	purine-containing compound biosynthetic process
HP:0500184	0.00768171284681	0.4	PDHX PDHA1	Abnormal CSF amino acid concentration
REAC:R-HSA-162582	0.00823431736973	1.0	PDHA1 PDK1 STAT5B PDK3 PDHX	Signal Transduction
HP:0500183	0.00870474912182	0.4	PDHX PDHA1	Abnormal CSF carboxylic acid concentration
GO:0009165	0.00985597470743	0.8	PDHA1 PDK1 PDK3 PDHX	nucleotide biosynthetic process
KEGG:05230	0.00996128881886	0.4	PDK1 PDHA1	Central carbon metabolism in cancer
GO:1901293	0.0106397767226	0.8	PDHA1 PDK1 PDK3 PDHX	nucleoside phosphate biosynthetic process
WP:WP4255	0.0128896073912	0.4	PDK1 STAT5B	Non small cell lung cancer
WP:WP3925	0.0197951791935	0.4	PDHX PDHA1	Amino acid metabolism
KEGG:04066	0.0217595858915	0.4	PDK1 PDHA1	HIF-1 signaling pathway
GO:0050812	0.0280843539964	0.4	PDK1 PDK3	regulation of acyl-CoA biosynthetic process
GO:0010510	0.0280843539964	0.4	PDK1 PDK3	regulation of acetyl-CoA biosynthetic process from pyruvate
GO:0004740	0.0468008499735	0.4	PDK1 PDK3	pyruvate dehydrogenase (acetyl-transferring) kinase activity
CORUM:2013	0.0498708842806	0.2	STAT5B	STAT5B homodimer complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
PDHA1	PDHB	1.0	0.958	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM Guru bioplex3_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
PDK3	PDK1	0.999	0.278	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM hein ()
PDK3	PDHB	0.999	0.124	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM treiber_WMM
PDHX	PDHA1	0.998	0.684	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHX	0.998	0.06	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	PDHA1	0.997	0.18	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM treiber_WMM
PDK1	PDHA1	0.996	0.29	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM
STAT5B	PDHX	0.993	0.078	hein_WMM bioplex_WMM bioplex3_WMM hein ()
PDHX	PDHB	0.991	0.568	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt_WMM
STAT5B	PDHA1	0.989	0.11	hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PDK1	PDHX	0.984	0.218	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
STAT5B	PDHB	0.981	0.086	hein_WMM bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
PDK1	PDHB	0.964	0.429538461538	bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
PDK3	STAT5B	0.789	0.024	bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
PDK1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHX	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDK3	huMAP3_00016.1 huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHA1	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
STAT5B	huMAP3_03752.1 huMAP3_04704.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1
PDHB	huMAP3_04704.1 huMAP3_04919.1 huMAP3_07514.1 huMAP3_08216.1 huMAP3_09761.1 huMAP3_10412.1 huMAP3_10899.1 huMAP3_11877.1 huMAP3_12248.1 huMAP3_14339.1 huMAP3_14864.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04704.1