hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04711.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| SMC6 | Structural maintenance of chromosomes protein 6 (SMC protein 6) (SMC-6) (hSMC6) | 5 | UniProt NCBI |
| SLF2 | SMC5-SMC6 complex localization factor protein 2 (Smc5/6 localization factor 1) | 5 | UniProt NCBI |
| NSMCE3 | Non-structural maintenance of chromosomes element 3 homolog (Non-SMC element 3 homolog) (Hepatocellular carcinoma-associated protein 4) (MAGE-G1 antigen) (Melanoma-associated antigen G1) (Necdin-like protein 2) | 5 | UniProt NCBI |
| ZNF597 | Zinc finger protein 597 | 5 | UniProt NCBI |
| NSMCE4A | Non-structural maintenance of chromosomes element 4 homolog A (NS4EA) (Non-SMC element 4 homolog A) | 5 | UniProt NCBI |
| SIMC1 | SUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation) | 5 | UniProt NCBI |
| NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog (Non-SMC element 1 homolog) (EC 2.3.2.27) | 5 | UniProt NCBI |
| SMC5 | Structural maintenance of chromosomes protein 5 (SMC protein 5) (SMC-5) (hSMC5) | 5 | UniProt NCBI |
| EID3 | EP300-interacting inhibitor of differentiation 3 (EID-3) (E1A-like inhibitor of differentiation 3) (EID-1-like inhibitor of differentiation 3) (Non-structural maintenance of chromosomes element 4 homolog B) (NS4EB) (Non-SMC element 4 homolog B) | 5 | UniProt NCBI |
| NSMCE2 | E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030915 | 3.92947304954e-22 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | Smc5-Smc6 complex |
| GO:0140588 | 1.96449738772e-21 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromatin looping |
| GO:0106068 | 5.61641098591e-20 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | SUMO ligase complex |
| WP:WP5407 | 1.88643698092e-14 | 0.7 | SLF2 NSMCE2 NSMCE1 EID3 NSMCE3 SMC6 SMC5 | 15q11q13 copy number variation |
| GO:0016925 | 5.28627122059e-14 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | protein sumoylation |
| REAC:R-HSA-3108214 | 1.35037862424e-12 | 0.7 | NSMCE2 NSMCE4A NSMCE1 EID3 NSMCE3 SMC6 SMC5 | SUMOylation of DNA damage response and repair proteins |
| GO:0032204 | 8.03500812881e-12 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | regulation of telomere maintenance |
| GO:0018205 | 2.93834167931e-11 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | peptidyl-lysine modification |
| GO:0000723 | 1.52610370508e-10 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | telomere maintenance |
| GO:0000781 | 1.70981246025e-10 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromosome, telomeric region |
| GO:0000724 | 3.44909497412e-10 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | double-strand break repair via homologous recombination |
| GO:0000725 | 4.22977320188e-10 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | recombinational repair |
| REAC:R-HSA-3108232 | 4.26034978912e-10 | 0.7 | NSMCE2 NSMCE4A NSMCE1 EID3 NSMCE3 SMC6 SMC5 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-2990846 | 5.31600144687e-10 | 0.7 | NSMCE2 NSMCE4A NSMCE1 EID3 NSMCE3 SMC6 SMC5 | SUMOylation |
| GO:0032200 | 7.22601911871e-10 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | telomere organization |
| GO:0000793 | 2.75988205034e-09 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | condensed chromosome |
| GO:0033044 | 7.55843717927e-09 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | regulation of chromosome organization |
| GO:0006310 | 1.29938331753e-08 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | DNA recombination |
| GO:0006302 | 2.66756098016e-08 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | double-strand break repair |
| GO:0098687 | 1.02313495819e-07 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromosomal region |
| GO:0051052 | 8.63231345351e-07 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | regulation of DNA metabolic process |
| GO:0006325 | 1.7696633617e-06 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromatin organization |
| GO:0006281 | 2.90137852994e-06 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | DNA repair |
| GO:0051276 | 3.88509243439e-06 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromosome organization |
| GO:0071824 | 5.72867304714e-06 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | protein-DNA complex organization |
| GO:0018193 | 9.04156487014e-06 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | peptidyl-amino acid modification |
| GO:0032446 | 1.37299459945e-05 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | protein modification by small protein conjugation |
| GO:0016605 | 2.89916951479e-05 | 0.5 | SMC6 NSMCE2 SIMC1 SMC5 SLF2 | PML body |
| GO:0070647 | 3.01453535252e-05 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | protein modification by small protein conjugation or removal |
| GO:0043687 | 5.08048355225e-05 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | post-translational protein modification |
| GO:0006974 | 6.73396461374e-05 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | DNA damage response |
| GO:0006259 | 0.000110282181646 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | DNA metabolic process |
| GO:1990234 | 0.000126088226089 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | transferase complex |
| GO:0034093 | 0.0002304395259 | 0.3 | SLF2 SMC5 NSMCE2 | positive regulation of maintenance of sister chromatid cohesion |
| GO:0034184 | 0.0002304395259 | 0.3 | SLF2 SMC5 NSMCE2 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| GO:0033043 | 0.000397106856374 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | regulation of organelle organization |
| REAC:R-HSA-597592 | 0.000686921776836 | 0.7 | NSMCE2 NSMCE4A NSMCE1 EID3 NSMCE3 SMC6 SMC5 | Post-translational protein modification |
| GO:0045876 | 0.000966803032193 | 0.3 | SLF2 SMC5 NSMCE2 | positive regulation of sister chromatid cohesion |
| GO:0034091 | 0.000966803032193 | 0.3 | SLF2 SMC5 NSMCE2 | regulation of maintenance of sister chromatid cohesion |
| GO:0034182 | 0.000966803032193 | 0.3 | SLF2 SMC5 NSMCE2 | regulation of maintenance of mitotic sister chromatid cohesion |
| GO:0000722 | 0.0018977127037 | 0.3 | SMC6 SMC5 NSMCE2 | telomere maintenance via recombination |
| GO:0034086 | 0.00328700479383 | 0.3 | SLF2 SMC5 NSMCE2 | maintenance of sister chromatid cohesion |
| GO:0034088 | 0.00328700479383 | 0.3 | SLF2 SMC5 NSMCE2 | maintenance of mitotic sister chromatid cohesion |
| REAC:R-HSA-392499 | 0.00618775137334 | 0.7 | NSMCE2 NSMCE4A NSMCE1 EID3 NSMCE3 SMC6 SMC5 | Metabolism of proteins |
| GO:0033554 | 0.00690847051977 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | cellular response to stress |
| GO:0007063 | 0.00780402634424 | 0.3 | SLF2 SMC5 NSMCE2 | regulation of sister chromatid cohesion |
| GO:0006312 | 0.00936146543831 | 0.3 | SMC6 SMC5 NSMCE2 | mitotic recombination |
| GO:0005694 | 0.0129065863791 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | chromosome |
| GO:1902494 | 0.0260248958425 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | catalytic complex |
| GO:0007064 | 0.033448305627 | 0.3 | SLF2 SMC5 NSMCE2 | mitotic sister chromatid cohesion |
| GO:0043933 | 0.0492164594924 | 0.8 | SLF2 SMC5 NSMCE2 NSMCE1 EID3 NSMCE4A SMC6 NSMCE3 | protein-containing complex organization |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| SMC6 | NSMCE3 | 1.0 | 0.896 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| NSMCE1 | SMC5 | 1.0 | 0.292 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SMC6 | NSMCE1 | 1.0 | 0.34 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () Malo bioplex3_HCT116 fraction |
| NSMCE3 | NSMCE1 | 1.0 | 0.576 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| SMC6 | SMC5 | 1.0 | 0.854 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo fraction |
| NSMCE3 | SMC5 | 1.0 | 0.508 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| NSMCE3 | NSMCE4A | 1.0 | 0.648 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NSMCE3 | NSMCE2 | 1.0 | 0.362 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM Malo bioplex3_HCT116 fraction |
| NSMCE1 | NSMCE2 | 1.0 | 0.522 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM Malo fraction |
| NSMCE4A | NSMCE1 | 0.999 | 0.494 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| NSMCE3 | EID3 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SMC5 | NSMCE2 | 0.999 | 0.252 | hein_WMM bioplex_WMM bioplex3_WMM Malo fraction |
| SMC6 | NSMCE2 | 0.999 | 0.32 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () Malo fraction |
| ZNF597 | SMC6 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF597 | NSMCE2 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF597 | SMC5 | 0.999 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SMC6 | NSMCE4A | 0.999 | 0.404 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () |
| ZNF597 | NSMCE3 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF597 | NSMCE1 | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| ZNF597 | NSMCE4A | 0.997 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLF2 | NSMCE3 | 0.997 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only | |
| NSMCE4A | SMC5 | 0.994 | 0.47 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| NSMCE1 | EID3 | 0.993 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| NSMCE4A | NSMCE2 | 0.992 | 0.402 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SLF2 | SMC6 | 0.991 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM hein () | |
| SMC6 | EID3 | 0.99 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| SLF2 | NSMCE4A | 0.988 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SIMC1 | NSMCE1 | 0.987 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| SIMC1 | NSMCE3 | 0.983 | 0.1 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM bioplex3_HCT116 WMM_only |
| SMC5 | EID3 | 0.983 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLF2 | NSMCE1 | 0.98 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SLF2 | SMC5 | 0.979 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SIMC1 | SLF2 | 0.972 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| SLF2 | NSMCE2 | 0.958 | hein_WMM bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only | |
| EID3 | NSMCE2 | 0.938 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| SIMC1 | NSMCE2 | 0.937 | 0.19 | bioplex_WMM bioplex3_WMM WMM_only |
| SIMC1 | SMC5 | 0.904 | 0.15 | bioplex_WMM bioplex3_WMM WMM_only |
| SIMC1 | SMC6 | 0.893 | 0.098 | bioplex3_HEK293 bioplex_WMM bioplex3_WMM WMM_only |
| SIMC1 | NSMCE4A | 0.712 | 0.126 | bioplex_WMM bioplex3_WMM WMM_only |
Related Complexes