List of Gene Names or Uniprot ACCs (ex. OFD1 PCM1 Q1MSJ5):

Enrichment (ex. cilium):

Protein (ex. Centrosomal protein):

Complex: huMAP3_04722.1

Confidence: Extremely High   ?

Proteins

Genename	Protein Name	Uniprot Annotation Score	Links
TBPL1	TATA box-binding protein-like 1 (TBP-like 1) (21 kDa TBP-like protein) (Second TBP of unique DNA protein) (STUD) (TATA box-binding protein-related factor 2) (TBP-related factor 2) (TBP-like factor) (TBP-related protein)	5	UniProt   NCBI
GTF2A1	Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]	5	UniProt   NCBI
TBP	TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)	5	UniProt   NCBI
GTF2A2	Transcription initiation factor IIA subunit 2 (General transcription factor IIA subunit 2) (TFIIA p12 subunit) (TFIIA-12) (TFIIAS) (Transcription initiation factor IIA gamma chain) (TFIIA-gamma)	5	UniProt   NCBI



Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:03022	2.37917869848e-09	1.0	TBP TBPL1 GTF2A2 GTF2A1	Basal transcription factors
CORUM:492	3.1903416886e-07	0.75	GTF2A1 GTF2A2 TBP	DA complex
GO:0005672	3.84480164306e-07	0.75	GTF2A1 GTF2A2 TBP	transcription factor TFIIA complex
CORUM:493	3.92637271982e-07	0.75	GTF2A1 GTF2A2 TBP	DAB complex
KEGG:05203	1.13419726708e-06	1.0	TBP TBPL1 GTF2A2 GTF2A1	Viral carcinogenesis
GO:0016251	1.737817715e-06	1.0	TBP TBPL1 GTF2A2 GTF2A1	RNA polymerase II general transcription initiation factor activity
GO:0140223	5.11991174176e-06	1.0	TBP TBPL1 GTF2A2 GTF2A1	general transcription initiation factor activity
CORUM:489	5.12628525639e-06	0.5	GTF2A1 GTF2A2	TFIIA complex
CORUM:490	5.12628525639e-06	0.5	GTF2A1 GTF2A2	TFIIA complex
CORUM:1221	1.53774525569e-05	0.5	GTF2A1 GTF2A2	TFIIA-TRF2 complex
REAC:R-HSA-167161	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	HIV Transcription Initiation
REAC:R-HSA-73779	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
REAC:R-HSA-76042	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II Transcription Initiation And Promoter Clearance
REAC:R-HSA-75953	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II Transcription Initiation
REAC:R-HSA-73776	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II Promoter Escape
REAC:R-HSA-167162	1.98686575917e-05	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II HIV Promoter Escape
REAC:R-HSA-167172	7.00887667092e-05	0.75	GTF2A1 GTF2A2 TBP	Transcription of the HIV genome
REAC:R-HSA-6807505	8.33911915483e-05	0.75	GTF2A1 GTF2A2 TBP	RNA polymerase II transcribes snRNA genes
REAC:R-HSA-674695	0.000110531761496	0.75	GTF2A1 GTF2A2 TBP	RNA Polymerase II Pre-transcription Events
GO:0000979	0.000139871762976	0.75	TBP TBPL1 GTF2A1	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091	0.000437924933217	0.75	GTF2A1 GTF2A2 TBP	RNA polymerase II general transcription initiation factor binding
GO:0006352	0.00045202142534	1.0	TBP TBPL1 GTF2A2 GTF2A1	DNA-templated transcription initiation
REAC:R-HSA-9018519	0.000464818544718	0.75	GTF2A1 GTF2A2 TBP	Estrogen-dependent gene expression
REAC:R-HSA-162599	0.000498740793897	0.75	GTF2A1 GTF2A2 TBP	Late Phase of HIV Life Cycle
REAC:R-HSA-162587	0.000650875640662	0.75	GTF2A1 GTF2A2 TBP	HIV Life Cycle
REAC:R-HSA-8939211	0.0014432337528	0.75	GTF2A1 GTF2A2 TBP	ESR-mediated signaling
GO:0005669	0.00172575455775	0.75	GTF2A1 GTF2A2 TBP	transcription factor TFIID complex
GO:0001046	0.00190418300832	0.75	TBP TBPL1 GTF2A1	core promoter sequence-specific DNA binding
WP:WP405	0.00198508114189	0.5	TBP GTF2A2	Eukaryotic transcription initiation
REAC:R-HSA-162906	0.0024623188735	0.75	GTF2A1 GTF2A2 TBP	HIV Infection
REAC:R-HSA-9006931	0.00343792850162	0.75	GTF2A1 GTF2A2 TBP	Signaling by Nuclear Receptors
GO:0140296	0.0037914498893	0.75	GTF2A1 GTF2A2 TBP	general transcription initiation factor binding
GO:0051123	0.00847564117007	0.75	GTF2A1 GTF2A2 TBP	RNA polymerase II preinitiation complex assembly
GO:0001098	0.00847564117007	0.75	GTF2A1 GTF2A2 TBP	basal transcription machinery binding
GO:0001099	0.00847564117007	0.75	GTF2A1 GTF2A2 TBP	basal RNA polymerase II transcription machinery binding
GO:0060261	0.00951168180783	0.75	GTF2A1 GTF2A2 TBP	positive regulation of transcription initiation by RNA polymerase II
GO:0070897	0.00951168180783	0.75	GTF2A1 GTF2A2 TBP	transcription preinitiation complex assembly
GO:2000144	0.0131184183431	0.75	GTF2A1 GTF2A2 TBP	positive regulation of DNA-templated transcription initiation
GO:0060260	0.0137962469792	0.75	GTF2A1 GTF2A2 TBP	regulation of transcription initiation by RNA polymerase II
GO:2000142	0.0183580179548	0.75	GTF2A1 GTF2A2 TBP	regulation of DNA-templated transcription initiation
GO:0016591	0.0192043220783	0.75	GTF2A1 GTF2A2 TBP	RNA polymerase II, holoenzyme
KEGG:05017	0.0192212154966	0.5	TBPL1 TBP	Spinocerebellar ataxia
CORUM:721	0.0249718442456	0.25	TBP	PU.1-TBP complex
KEGG:05166	0.0480473295333	0.5	TBPL1 TBP	Human T-cell leukemia virus 1 infection
GO:0055029	0.048062454325	0.75	GTF2A1 GTF2A2 TBP	nuclear DNA-directed RNA polymerase complex
GO:0000428	0.0496619752722	0.75	GTF2A1 GTF2A2 TBP	DNA-directed RNA polymerase complex
CORUM:629	0.049938562206	0.25	TBPL1	BLM-TRF2 complex
CORUM:5736	0.049938562206	0.25	TBP	Pre-initiation complex (PIC)



Edges

Protein 1	Protein 2	Score ?	ProteomeHD?	Evidence ?
GTF2A1	GTF2A2	1.0	0.224	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM     fraction
GTF2A1	TBPL1	1.0	0.12	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM
TBP	GTF2A1	0.999	0.094	bioplex3_HEK293     bioplex ()     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     gupta_WMM
TBPL1	GTF2A2	0.997	0.09	bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     youn_WMM     bioplex3_HCT116     gupta_WMM     WMM_only
TBP	GTF2A2	0.995	0.204	bioplex3_HEK293     bioplex_WMM     bioplex3_WMM     bioplex3_HCT116     gupta_WMM     WMM_only
TBP	TBPL1	0.881	0.124	bioplex_WMM     bioplex3_WMM     gupta_WMM     WMM_only





Related Complexes

Genename	Complexes
TBPL1	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_15044.1
GTF2A1	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_14957.1
TBP	huMAP3_00597.1 huMAP3_04057.1 huMAP3_04722.1 huMAP3_06625.1 huMAP3_10303.1 huMAP3_10806.1 huMAP3_13329.1 huMAP3_14501.1
GTF2A2	huMAP3_04057.1 huMAP3_04119.1 huMAP3_04134.1 huMAP3_04356.1 huMAP3_04722.1 huMAP3_10303.1 huMAP3_13329.1 huMAP3_14501.1 huMAP3_15044.1