hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04725.1
Complex Portal: CPX-16516
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| KIF13A | Kinesin-like protein KIF13A (Kinesin-like protein RBKIN) | 5 | UniProt NCBI |
| KIF1A | Kinesin-like protein KIF1A (Axonal transporter of synaptic vesicles) (Microtubule-based motor KIF1A) (Unc-104- and KIF1A-related protein) (hUnc-104) | 5 | UniProt NCBI |
| KIF18B | Kinesin-like protein KIF18B | 5 | UniProt NCBI |
| KIF15 | Kinesin-like protein KIF15 (Kinesin-like protein 2) (hKLP2) (Kinesin-like protein 7) (Serologically defined breast cancer antigen NY-BR-62) | 5 | UniProt NCBI |
| KIF13B | Kinesin-like protein KIF13B (Kinesin-like protein GAKIN) | 5 | UniProt NCBI |
| KIF1B | Kinesin-like protein KIF1B (Klp) | 5 | UniProt NCBI |
| KIFBP | KIF-binding protein (KIF1-binding protein) (Kinesin family binding protein) | 5 | UniProt NCBI |
| KIF18A | Kinesin-like protein KIF18A (Marrow stromal KIF18A) (MS-KIF18A) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0005871 | 1.45676017843e-13 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | kinesin complex |
| GO:0003777 | 1.89128383461e-12 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule motor activity |
| KEGG:04814 | 7.08368733142e-12 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | Motor proteins |
| REAC:R-HSA-983189 | 1.13154713205e-11 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Kinesins |
| GO:0003774 | 9.71897992726e-11 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | cytoskeletal motor activity |
| REAC:R-HSA-6811434 | 3.32426359213e-10 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | COPI-dependent Golgi-to-ER retrograde traffic |
| GO:0016887 | 9.99794276215e-10 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | ATP hydrolysis activity |
| GO:0005875 | 9.99794276215e-10 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule associated complex |
| REAC:R-HSA-8856688 | 2.13958130543e-09 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Golgi-to-ER retrograde transport |
| REAC:R-HSA-983231 | 8.17326655106e-09 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-6811442 | 2.86020037528e-08 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Intra-Golgi and retrograde Golgi-to-ER traffic |
| GO:0008017 | 4.37253020669e-08 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule binding |
| GO:0007018 | 2.74807631192e-07 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule-based movement |
| GO:0005874 | 2.82049533806e-07 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule |
| GO:0015631 | 5.12284374651e-07 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | tubulin binding |
| GO:0007017 | 1.24366084878e-06 | 1.0 | KIF13B KIF15 KIF1A KIF13A KIF18B KIFBP KIF1B KIF18A | microtubule-based process |
| GO:0008092 | 1.49379391307e-06 | 1.0 | KIF13B KIF15 KIF1A KIF13A KIF18B KIFBP KIF1B KIF18A | cytoskeletal protein binding |
| GO:0008574 | 1.8396911621e-06 | 0.5 | KIF1A KIF18A KIF18B KIF1B | plus-end-directed microtubule motor activity |
| GO:0017111 | 2.24177372252e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | ribonucleoside triphosphate phosphatase activity |
| GO:0140657 | 4.57733787163e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | ATP-dependent activity |
| GO:0016462 | 5.07696792989e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | pyrophosphatase activity |
| GO:0016818 | 5.07696792989e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| GO:0016817 | 5.07696792989e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | hydrolase activity, acting on acid anhydrides |
| GO:0099513 | 5.91368871408e-06 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | polymeric cytoskeletal fiber |
| REAC:R-HSA-109582 | 1.17048169432e-05 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Hemostasis |
| REAC:R-HSA-199991 | 1.97177804739e-05 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Membrane Trafficking |
| REAC:R-HSA-5653656 | 2.7250868174e-05 | 0.75 | KIF1A KIF1B KIF13B KIF18B KIF18A KIF15 | Vesicle-mediated transport |
| GO:0099512 | 4.35604559488e-05 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | supramolecular fiber |
| GO:0099081 | 4.75418682301e-05 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | supramolecular polymer |
| GO:0099080 | 0.00099796899113 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | supramolecular complex |
| GO:0015630 | 0.00285315545087 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | microtubule cytoskeleton |
| GO:0019894 | 0.0195375863112 | 0.375 | KIF1B KIF18B KIFBP | kinesin binding |
| GO:0005856 | 0.0483717117681 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | cytoskeleton |
| GO:0016787 | 0.0488119806382 | 0.875 | KIF13B KIF15 KIF1A KIF13A KIF18B KIF1B KIF18A | hydrolase activity |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| KIF18A | KIFBP | 1.0 | 0.084 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt hein () bioplex3_HCT116 boldt_WMM |
| KIF1B | KIF1A | 1.0 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | ||
| KIF13B | KIFBP | 0.999 | 0.038 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | |
| KIF13A | KIFBP | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 | ||
| KIF15 | KIFBP | 0.995 | 0.054 |
structurally_consistent (dimer)
|
hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116 |
| KIF18B | KIFBP | 0.995 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| KIF18A | KIF18B | 0.993 | hein_WMM bioplex_WMM bioplex3_WMM hein () | ||
| KIF1A | KIFBP | 0.967 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM | ||
| KIF1B | KIFBP | 0.96 | 0.11 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM bioplex3_HCT116 gupta_WMM | |
| KIF13A | KIF13B | 0.815 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF15 | KIF13B | 0.788 | 0.042 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF18A | KIF15 | 0.764 | 0.224 |
mutually_exclusive (Q96EK5)
|
bioplex_WMM bioplex3_WMM WMM_only |
| KIF13A | KIF15 | 0.73 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF1B | KIF15 | 0.715 | 0.106 | bioplex_WMM bioplex3_WMM fraction | |
| KIF18A | KIF13A | 0.603 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF18A | KIF13B | 0.59 | 0.156 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF1B | KIF18A | 0.586 | 0.094 | bioplex_WMM bioplex3_WMM WMM_only | |
| KIF1B | KIF13A | 0.539 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| KIF1B | KIF13B | 0.507 | 0.098 | youn () bioplex_WMM bioplex3_WMM boldt youn_WMM boldt_WMM WMM_only | |
| KIF13A | KIF18B | 0.187 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF18B | KIF15 | 0.14 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF18A | KIF1A | 0.139 | bioplex_WMM bioplex3_WMM WMM_only | ||
| KIF1A | KIF15 | 0.124 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| KIF1A | KIF18B | 0.096 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| KIF1B | KIF18B | 0.087 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| KIF18B | KIF13B | 0.086 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| KIF1A | KIF13B | 0.049 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only | ||
| KIF13A | KIF1A | 0.032 | bioplex_WMM bioplex3_WMM youn_WMM gupta_WMM WMM_only |
Related Complexes