hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04735.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| HES1 | Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL) | 5 | UniProt NCBI |
| TLE1 | Transducin-like enhancer protein 1 (E(Sp1) homolog) (Enhancer of split groucho-like protein 1) (ESG1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04330 | 0.000183378615366 | 1.0 | HES1 TLE1 | Notch signaling pathway |
| WP:WP4844 | 0.000185152102942 | 1.0 | HES1 TLE1 | Influence of laminopathies on Wnt signaling |
| WP:WP61 | 0.000402652619272 | 1.0 | HES1 TLE1 | Notch signaling pathway |
| WP:WP4879 | 0.000460113616736 | 1.0 | HES1 TLE1 | Overlap between signal transduction pathways contributing to LMNA laminopathies |
| REAC:R-HSA-2122947 | 0.00133283416666 | 1.0 | HES1 TLE1 | NOTCH1 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-1980143 | 0.00292369135789 | 1.0 | HES1 TLE1 | Signaling by NOTCH1 |
| CORUM:3120 | 0.0249718442457 | 0.5 | TLE1 | OCT1-OBF1-DNA-TLE1 complex |
| CORUM:3125 | 0.0249718442457 | 0.5 | TLE1 | TLE1 homodimer complex |
| CORUM:3127 | 0.0249718442457 | 0.5 | TLE1 | TLE-Histone H3 complex |
| CORUM:3164 | 0.0249718442457 | 0.5 | TLE1 | HESX1-TLE1 complex |
| REAC:R-HSA-157118 | 0.0353816208396 | 1.0 | HES1 TLE1 | Signaling by NOTCH |
| KEGG:04950 | 0.0356198329076 | 0.5 | HES1 | Maturity onset diabetes of the young |
| WP:WP3593 | 0.0373151717536 | 0.5 | HES1 | MicroRNA for targeting cancer growth and vascularization in glioblastoma |
| CORUM:3124 | 0.0499419797295 | 0.5 | TLE1 | TLE1-TLE2 complex |
| CORUM:3150 | 0.0499419797295 | 0.5 | TLE1 | NK-3-Groucho complex |
| CORUM:6769 | 0.0499419797295 | 0.5 | TLE1 | TBX20-TLE1 repressor complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TLE1 | HES1 | 0.997 | 0.108 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
Related Complexes