hu.MAP 3.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: huMAP3_04773.1
Complex Portal: CPX-13077
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PNRC1 | Proline-rich nuclear receptor coactivator 1 (Proline-rich protein 2) (Protein B4-2) | 4 | UniProt NCBI |
| PRAG1 | Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223) | 5 | UniProt NCBI |
| DCP1A | mRNA-decapping enzyme 1A (EC 3.6.1.62) (Smad4-interacting transcriptional co-activator) (Transcription factor SMIF) | 5 | UniProt NCBI |
| DCP1B | mRNA-decapping enzyme 1B (EC 3.6.1.62) | 5 | UniProt NCBI |
| DDX6 | Probable ATP-dependent RNA helicase DDX6 (EC 3.6.4.13) (ATP-dependent RNA helicase p54) (DEAD box protein 6) (Oncogene RCK) | 5 | UniProt NCBI |
| EDC3 | Enhancer of mRNA-decapping protein 3 (LSM16 homolog) (YjeF N-terminal domain-containing protein 2) (YjeF_N2) (hYjeF_N2) (YjeF domain-containing protein 1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-430039 | 1.97831742843e-09 | 0.666666666667 | EDC3 DDX6 DCP1A DCP1B | mRNA decay by 5' to 3' exoribonuclease |
| CORUM:559 | 4.675933868e-08 | 0.5 | DDX6 DCP1A EDC3 | Decapping complex |
| KEGG:03018 | 4.41358358689e-07 | 0.666666666667 | EDC3 DDX6 DCP1A DCP1B | RNA degradation |
| REAC:R-HSA-429914 | 4.92132752099e-07 | 0.666666666667 | EDC3 DDX6 DCP1A DCP1B | Deadenylation-dependent mRNA decay |
| GO:0000932 | 9.28738723532e-07 | 0.833333333333 | DDX6 PNRC1 EDC3 DCP1A DCP1B | P-body |
| GO:0031087 | 1.92180881975e-05 | 0.5 | EDC3 DCP1A DCP1B | deadenylation-independent decapping of nuclear-transcribed mRNA |
| GO:0031086 | 3.84302573496e-05 | 0.5 | EDC3 DCP1A DCP1B | nuclear-transcribed mRNA catabolic process, deadenylation-independent decay |
| GO:0036464 | 0.000161105021197 | 0.833333333333 | DDX6 PNRC1 EDC3 DCP1A DCP1B | cytoplasmic ribonucleoprotein granule |
| GO:0035770 | 0.000239709927645 | 0.833333333333 | DDX6 PNRC1 EDC3 DCP1A DCP1B | ribonucleoprotein granule |
| GO:0110156 | 0.000548960443183 | 0.5 | EDC3 DCP1A DCP1B | methylguanosine-cap decapping |
| GO:0110154 | 0.0010743908712 | 0.5 | EDC3 DCP1A DCP1B | RNA decapping |
| GO:0000956 | 0.00242244235372 | 0.666666666667 | EDC3 PNRC1 DCP1A DCP1B | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-8953854 | 0.0121605407448 | 0.666666666667 | EDC3 DDX6 DCP1A DCP1B | Metabolism of RNA |
| GO:0006402 | 0.0265218418455 | 0.666666666667 | EDC3 PNRC1 DCP1A DCP1B | mRNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Interface Overlap | Evidence |
|---|---|---|---|---|---|
| DDX6 | DCP1B | 1.0 | 0.138 |
structurally_consistent (dimer)
|
youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1B | EDC3 | 1.0 | 0.058 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| DDX6 | DCP1A | 1.0 | 0.208 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM |
| DCP1A | EDC3 | 1.0 | 0.502 | hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM hein () bioplex3_HCT116 gupta_WMM boldt_WMM treiber_WMM | |
| DDX6 | EDC3 | 0.999 | 0.284 |
structurally_consistent (dimer)
|
hein_WMM youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM boldt youn_WMM bioplex3_HCT116 gupta_WMM fraction boldt_WMM |
| PNRC1 | DCP1A | 0.997 | hein_WMM youn () bioplex_WMM bioplex3_WMM hein () | ||
| DDX6 | PNRC1 | 0.991 | hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM youn_WMM | ||
| DCP1A | DCP1B | 0.991 | 0.04 |
mutually_exclusive (P26196)
|
youn () bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| PRAG1 | EDC3 | 0.981 | 0.07 | hein_WMM bioplex3_WMM WMM_only | |
| PNRC1 | EDC3 | 0.975 | hein_WMM bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PRAG1 | DCP1A | 0.954 | 0.072 | hein_WMM bioplex3_WMM WMM_only | |
| DDX6 | PRAG1 | 0.947 | 0.180366197183 | hein_WMM bioplex3_WMM WMM_only | |
| PNRC1 | DCP1B | 0.375 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only | ||
| PRAG1 | PNRC1 | 0.248 | hein_WMM WMM_only | ||
| PRAG1 | DCP1B | 0.079 | 0.122 | bioplex3_WMM WMM_only |
Related Complexes