hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04783.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| TRIM5 | Tripartite motif-containing protein 5 (EC 2.3.2.27) (RING finger protein 88) (RING-type E3 ubiquitin transferase TRIM5) | 5 | UniProt NCBI |
| AARS1 | Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42) | 5 | UniProt NCBI |
| APEX1 | DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (REF-1) (Redox factor-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial] | 5 | UniProt NCBI |
| YARS1 | Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed] | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00970 | 0.000688034410789 | 0.666666666667 | AARS1 YARS1 | Aminoacyl-tRNA biosynthesis |
| REAC:R-HSA-379716 | 0.00188000535098 | 0.666666666667 | AARS1 YARS1 | Cytosolic tRNA aminoacylation |
| REAC:R-HSA-379724 | 0.00585997836812 | 0.666666666667 | AARS1 YARS1 | tRNA Aminoacylation |
| HP:0003431 | 0.0173967419879 | 0.666666666667 | AARS1 YARS1 | Decreased motor nerve conduction velocity |
| HP:0040131 | 0.0187458629677 | 0.666666666667 | AARS1 YARS1 | Abnormal motor nerve conduction velocity |
| HP:0008619 | 0.0262448238426 | 0.666666666667 | AARS1 YARS1 | Bilateral sensorineural hearing impairment |
| HP:0000608 | 0.037868427304 | 0.666666666667 | AARS1 YARS1 | Macular degeneration |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| APEX1 | YARS1 | 0.993 | 0.292 | bioplex () bioplex_WMM bioplex3_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
| AARS1 | YARS1 | 0.968 | 0.778 | bioplex_WMM bioplex3_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM WMM_only |
| TRIM5 | YARS1 | 0.957 | 0.144 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 |
| APEX1 | AARS1 | 0.92 | 0.2 | bioplex_WMM bioplex3_WMM gupta_WMM WMM_only boldt_WMM |
Related Complexes