hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04785.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| PCDHA4 | Protocadherin alpha-4 (PCDH-alpha-4) | 5 | UniProt NCBI |
| TCL1A | T-cell leukemia/lymphoma protein 1A (Oncogene TCL-1) (Oncogene TCL1) (Protein p14 TCL1) | 5 | UniProt NCBI |
| DNMT3A | DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA) | 5 | UniProt NCBI |
| DNMT3B | DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB) | 5 | UniProt NCBI |
| PCDHA1 | Protocadherin alpha-1 (PCDH-alpha-1) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP4288 | 0.00100346979189 | 0.4 | DNMT3B DNMT3A | MTHFR deficiency |
| WP:WP3657 | 0.00100346979189 | 0.4 | DNMT3B DNMT3A | Hematopoietic stem cell gene regulation by GABP alpha beta complex |
| REAC:R-HSA-4655427 | 0.001593300657 | 0.4 | DNMT3B DNMT3A | SUMOylation of DNA methylation proteins |
| WP:WP241 | 0.00161852668418 | 0.4 | DNMT3B DNMT3A | One carbon metabolism |
| KEGG:00270 | 0.00467646579264 | 0.4 | DNMT3B DNMT3A | Cysteine and methionine metabolism |
| GO:0090116 | 0.00468200720083 | 0.4 | DNMT3B DNMT3A | C-5 methylation of cytosine |
| WP:WP2525 | 0.00867145853418 | 0.4 | DNMT3B DNMT3A | Trans sulfuration one carbon metabolism and related pathways |
| GO:0003886 | 0.0140440992017 | 0.4 | DNMT3B DNMT3A | DNA (cytosine-5-)-methyltransferase activity |
| GO:0032776 | 0.0140440992017 | 0.4 | DNMT3B DNMT3A | DNA methylation on cytosine |
| GO:0009008 | 0.0140440992017 | 0.4 | DNMT3B DNMT3A | DNA-methyltransferase activity |
| REAC:R-HSA-5334118 | 0.0200193611976 | 0.4 | DNMT3B DNMT3A | DNA methylation |
| REAC:R-HSA-9710421 | 0.0275944536635 | 0.4 | DNMT3B DNMT3A | Defective pyroptosis |
| REAC:R-HSA-212300 | 0.0275944536635 | 0.4 | DNMT3B DNMT3A | PRC2 methylates histones and DNA |
| KEGG:05206 | 0.0484667159694 | 0.4 | DNMT3B DNMT3A | MicroRNAs in cancer |
| CORUM:2650 | 0.0498708842806 | 0.2 | DNMT3B | DNMT3B-DNMT3L complex |
| CORUM:2651 | 0.0498708842806 | 0.2 | DNMT3A | DNMT3L-DNMT3A complex |
| CORUM:3849 | 0.0498708842806 | 0.2 | TCL1A | TCL1 homotrimer complex |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| TCL1A | DNMT3B | 0.998 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | PCDHA1 | 0.998 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM bioplex3_HCT116 | |
| TCL1A | DNMT3A | 0.997 | 0.104 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| DNMT3A | DNMT3B | 0.989 | bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| PCDHA4 | TCL1A | 0.984 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | DNMT3B | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| PCDHA4 | DNMT3A | 0.981 | bioplex3_WMM bioplex3_HCT116 WMM_only | |
| TCL1A | PCDHA1 | 0.902 | bioplex3_WMM WMM_only | |
| DNMT3A | PCDHA1 | 0.869 | bioplex3_WMM WMM_only | |
| DNMT3B | PCDHA1 | 0.768 | bioplex3_WMM WMM_only |
Related Complexes