hu.MAP 3.0: Complex View
Human Protein Complex Map
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Complex: huMAP3_04801.1
Confidence: Extremely High
Proteins| Genename | Protein Name | Uniprot Annotation Score | Links |
|---|---|---|---|
| BTG2 | Protein BTG2 (BTG family member 2) (NGF-inducible anti-proliferative protein PC3) | 5 | UniProt NCBI |
| BTG1 | Protein BTG1 (B-cell translocation gene 1 protein) | 5 | UniProt NCBI |
| PABPN1L | Embryonic polyadenylate-binding protein 2 (Embryonic poly(A)-binding protein 2) (ePABP-2) (ePABP2) (Embryonic poly(A)-binding protein type II) (Poly(A)-binding protein nuclear-like 1) | 3 | UniProt NCBI |
| CNOT7 | CCR4-NOT transcription complex subunit 7 (EC 3.1.13.4) (BTG1-binding factor 1) (CCR4-associated factor 1) (CAF-1) (Caf1a) | 5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03018 | 2.12742945788e-05 | 0.75 | BTG2 BTG1 CNOT7 | RNA degradation |
| REAC:R-HSA-6804115 | 0.00156635412759 | 0.5 | BTG2 CNOT7 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| REAC:R-HSA-6791312 | 0.0101102645678 | 0.5 | BTG2 CNOT7 | TP53 Regulates Transcription of Cell Cycle Genes |
| GO:0000288 | 0.0144970047051 | 0.75 | BTG2 PABPN1L CNOT7 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0061157 | 0.0434703685672 | 0.75 | BTG2 PABPN1L CNOT7 | mRNA destabilization |
| GO:0050779 | 0.048062454325 | 0.75 | BTG2 PABPN1L CNOT7 | RNA destabilization |
| GO:0061014 | 0.0496619752722 | 0.75 | BTG2 PABPN1L CNOT7 | positive regulation of mRNA catabolic process |
Edges
| Protein 1 | Protein 2 | Score | ProteomeHD | Evidence |
|---|---|---|---|---|
| CNOT7 | BTG2 | 0.996 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM | |
| CNOT7 | PABPN1L | 0.992 | 0.088 | bioplex3_HEK293 bioplex3_WMM bioplex3_HCT116 WMM_only |
| CNOT7 | BTG1 | 0.992 | 0.062 | youn () bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM |
| BTG2 | BTG1 | 0.606 | bioplex_WMM bioplex3_WMM youn_WMM WMM_only |
Related Complexes