hu.MAP 3.0: Complex View

Human Protein Complex Map

Complex: huMAP3_04821.1

Complex Portal: CPX-14245

Confidence: Extremely High

Genename	Protein Name	Uniprot Annotation Score	Links
TSC1	Hamartin (Tuberous sclerosis 1 protein)	5	UniProt NCBI
TBC1D7	TBC1 domain family member 7 (Cell migration-inducing protein 23)	5	UniProt NCBI
KIF27	Kinesin-like protein KIF27	5	UniProt NCBI
TSC2	Tuberin (Tuberous sclerosis 2 protein)	5	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
CORUM:6889	7.01606139244e-10	0.75	TSC2 TSC1 TBC1D7	TSC complex
GO:0033596	3.84480164306e-07	0.75	TSC2 TSC1 TBC1D7	TSC1-TSC2 complex
CORUM:75	5.12628525639e-06	0.5	TSC2 TSC1	TSC1-TSC2 complex
CORUM:7157	5.12628525639e-06	0.5	TSC2 TSC1	TSC1-TSC2 complex
REAC:R-HSA-8854214	1.28002609524e-05	0.75	TSC2 TSC1 TBC1D7	TBC/RABGAPs
CORUM:4151	3.07520988333e-05	0.5	TSC2 TSC1	TSC (TSC1, TSC2, AXIN, GSK3) complex
REAC:R-HSA-165181	3.07549051138e-05	0.5	TSC2 TSC1	Inhibition of TSC complex formation by PKB
HP:0011852	3.34429085774e-05	0.5	TSC2 TSC1	Chylopericardium
HP:0001355	3.55023502799e-05	0.75	TSC2 TSC1 TBC1D7	Megalencephaly
WP:WP4549	7.50207145459e-05	0.75	TSC2 TSC1 TBC1D7	Fragile X syndrome
HP:0010762	0.000100319571443	0.5	TSC2 TSC1	Chordoma
HP:0012797	0.000100319571443	0.5	TSC2 TSC1	Lymphatic vessel neoplasm
HP:0009727	0.000100319571443	0.5	TSC2 TSC1	Achromatic retinal patches
HP:0012798	0.000100319571443	0.5	TSC2 TSC1	Pulmonary lymphangiomyomatosis
HP:0009724	0.000100319571443	0.5	TSC2 TSC1	Subungual fibromas
HP:0009718	0.000100319571443	0.5	TSC2 TSC1	Subependymal giant-cell astrocytoma
HP:0012778	0.000100319571443	0.5	TSC2 TSC1	Retinal astrocytic hamartoma
HP:0100826	0.000100319571443	0.5	TSC2 TSC1	Neoplasm of the nail
HP:0009717	0.000100319571443	0.5	TSC2 TSC1	Cortical tubers
HP:0100804	0.000100319571443	0.5	TSC2 TSC1	Ungual fibroma
KEGG:04150	0.000180381602802	0.75	TSC2 TSC1 TBC1D7	mTOR signaling pathway
HP:0009734	0.000200620835246	0.5	TSC2 TSC1	Optic nerve glioma
HP:0009716	0.000200620835246	0.5	TSC2 TSC1	Subependymal nodules
REAC:R-HSA-9007101	0.000284930280132	0.75	TSC2 TSC1 TBC1D7	Rab regulation of trafficking
HP:0006772	0.000334337547576	0.5	TSC2 TSC1	Renal angiomyolipoma
HP:0009730	0.000334337547576	0.5	TSC2 TSC1	Rhabdomyoma
HP:0032051	0.000334337547576	0.5	TSC2 TSC1	Focal cortical dysplasia type II
HP:0009729	0.000334337547576	0.5	TSC2 TSC1	Cardiac rhabdomyoma
HP:0009721	0.000334337547576	0.5	TSC2 TSC1	Shagreen patch
REAC:R-HSA-199991	0.000426838992032	1.0	TSC2 TSC1 KIF27 TBC1D7	Membrane Trafficking
HP:0100898	0.000501460556964	0.5	TSC2 TSC1	Connective tissue nevi
REAC:R-HSA-5653656	0.000530772712934	1.0	TSC2 TSC1 KIF27 TBC1D7	Vesicle-mediated transport
WP:WP4141	0.000535373329556	0.5	TSC2 TSC1	PI3K AKT mTOR vitamin D3 signaling
WP:WP3879	0.000535373329556	0.5	TSC2 TSC1	4 hydroxytamoxifen dexamethasone and retinoic acids regulation of p27 expression
WP:WP2509	0.000588856887782	0.5	TSC2 TSC1	Nanoparticle triggered autophagic cell death
HP:0008696	0.000701980712879	0.5	TSC2 TSC1	Renal hamartoma
HP:0010953	0.000701980712879	0.5	TSC2 TSC1	Noncommunicating hydrocephalus
HP:0009719	0.000935888865729	0.5	TSC2 TSC1	Hypomelanotic macule
HP:0040030	0.000935888865729	0.5	TSC2 TSC1	Chorioretinal hypopigmentation
WP:WP3676	0.00103429913449	0.5	TSC2 TSC1	BDNF TrkB signaling
HP:0008208	0.00120317586686	0.5	TSC2 TSC1	Parathyroid hyperplasia
HP:0007449	0.00120317586686	0.5	TSC2 TSC1	Confetti-like hypopigmented macules
WP:WP1471	0.00142851438729	0.5	TSC2 TSC1	Target of rapamycin signaling
HP:0009723	0.00183784982408	0.5	TSC2 TSC1	Abnormality of the subungual region
HP:0007661	0.00183784982408	0.5	TSC2 TSC1	Abnormality of chorioretinal pigmentation
WP:WP4577	0.00198508114189	0.5	TSC2 TSC1	Neurodegeneration with brain iron accumulation NBIA subtypes pathway
HP:0008762	0.00220521848756	0.5	TSC2 TSC1	Repetitive compulsive behavior
HP:0030405	0.00220521848756	0.5	TSC2 TSC1	Pancreatic endocrine tumor
HP:0002897	0.00220521848756	0.5	TSC2 TSC1	Parathyroid adenoma
WP:WP4539	0.002406667175	0.5	TSC2 TSC1	Synaptic signaling pathways associated with autism spectrum disorder
WP:WP363	0.00251837499235	0.5	TSC2 TSC1	Wnt signaling pathway
HP:0100544	0.00260592941411	0.5	TSC2 TSC1	Neoplasm of the heart
HP:0100570	0.00260592941411	0.5	TSC2 TSC1	Carcinoid tumor
HP:0032046	0.00303997345979	0.5	TSC2 TSC1	Focal cortical dysplasia
HP:0007206	0.00303997345979	0.5	TSC2 TSC1	Hemimegalencephaly
HP:0100733	0.00350734148159	0.5	TSC2 TSC1	Neoplasm of the parathyroid gland
HP:0100766	0.00350734148159	0.5	TSC2 TSC1	Abnormal lymphatic vessel morphology
HP:0200040	0.00350734148159	0.5	TSC2 TSC1	Epidermoid cyst
HP:0007042	0.00350734148159	0.5	TSC2 TSC1	Focal white matter lesions
WP:WP5180	0.00363720277712	0.5	TSC2 TSC1	DYRK1A involvement regarding cell proliferation in brain development
REAC:R-HSA-380972	0.00415229579539	0.5	TSC2 TSC1	Energy dependent regulation of mTOR by LKB1-AMPK
GO:1904262	0.00440499676786	0.75	TSC2 TSC1 TBC1D7	negative regulation of TORC1 signaling
HP:0000169	0.00454201288615	0.5	TSC2 TSC1	Gingival fibromatosis
WP:WP1403	0.00464837292584	0.5	TSC2 TSC1	AMP activated protein kinase signaling
HP:0002888	0.0051092979876	0.5	TSC2 TSC1	Ependymoma
HP:0010310	0.0051092979876	0.5	TSC2 TSC1	Chylothorax
HP:0011766	0.0051092979876	0.5	TSC2 TSC1	Abnormal parathyroid morphology
HP:0002446	0.0057098705025	0.5	TSC2 TSC1	Astrocytosis
HP:0009731	0.0057098705025	0.5	TSC2 TSC1	Cerebral hamartoma
HP:0007894	0.0057098705025	0.5	TSC2 TSC1	Hypopigmentation of the fundus
WP:WP4746	0.00578263137464	0.5	TSC2 TSC1	Thyroid hormones production and peripheral downstream signaling effects
WP:WP4674	0.00612927993034	0.5	TSC2 TSC1	Head and neck squamous cell carcinoma
WP:WP5098	0.00685264055756	0.5	TSC2 TSC1	T cell activation SARS CoV 2
HP:0025245	0.00701084122037	0.5	TSC2 TSC1	Cutaneous cyst
HP:0009594	0.00701084122037	0.5	TSC2 TSC1	Retinal hamartoma
HP:0009592	0.00701084122037	0.5	TSC2 TSC1	Astrocytoma
WP:WP4018	0.00703973989842	0.5	TSC2 TSC1	Clear cell renal cell carcinoma pathways
WP:WP2261	0.00742144474402	0.5	TSC2 TSC1	Glioblastoma signaling pathways
HP:0012086	0.00771122114953	0.5	TSC2 TSC1	Abnormal urinary color
HP:0100803	0.00771122114953	0.5	TSC2 TSC1	Abnormality of the periungual region
KEGG:04211	0.00806816574582	0.5	TSC2 TSC1	Longevity regulating pathway
REAC:R-HSA-165159	0.00837722051003	0.5	TSC2 TSC1	MTOR signalling
HP:0001407	0.00844485194452	0.5	TSC2 TSC1	Hepatic cysts
HP:0001716	0.00844485194452	0.5	TSC2 TSC1	Wolff-Parkinson-White syndrome
KEGG:05231	0.00847251296121	0.5	TSC2 TSC1	Choline metabolism in cancer
HP:0010568	0.0100118295947	0.5	TSC2 TSC1	Hamartoma of the eye
HP:0020073	0.0100118295947	0.5	TSC2 TSC1	Hypopigmented macule
HP:0030670	0.0100118295947	0.5	TSC2 TSC1	Hamartoma of the orbital region
WP:WP4321	0.0103731686562	0.5	TSC2 TSC1	Thermogenesis
HP:0009720	0.0108451581837	0.5	TSC2 TSC1	Adenoma sebaceum
HP:0002666	0.0108451581837	0.5	TSC2 TSC1	Pheochromocytoma
WP:WP2263	0.0113062844995	0.5	TSC2 TSC1	Androgen receptor network in prostate cancer
HP:0004309	0.0117117011059	0.5	TSC2 TSC1	Ventricular preexcitation
HP:0009728	0.0117117011059	0.5	TSC2 TSC1	Neoplasm of striated muscle
GO:0032007	0.0124631389739	0.75	TSC2 TSC1 TBC1D7	negative regulation of TOR signaling
HP:0031605	0.0155098335254	0.5	TSC2 TSC1	Abnormality of fundus pigmentation
HP:0010615	0.0155098335254	0.5	TSC2 TSC1	Angiofibromas
KEGG:04152	0.0157117070582	0.5	TSC2 TSC1	AMPK signaling pathway
WP:WP3915	0.0162815495406	0.5	TSC2 TSC1	Angiopoietin like protein 8 regulatory pathway
KEGG:04072	0.0165563012031	0.5	TSC2 TSC1	Phospholipase D signaling pathway
HP:0001698	0.0176079483787	0.5	TSC2 TSC1	Pericardial effusion
HP:0100634	0.018706736024	0.5	TSC2 TSC1	Neuroendocrine neoplasm
KEGG:04910	0.0195294442288	0.5	TSC2 TSC1	Insulin signaling pathway
HP:0200035	0.0222019103471	0.5	TSC2 TSC1	Skin plaque
HP:0006706	0.0222019103471	0.5	TSC2 TSC1	Cystic liver disease
KEGG:04218	0.0240987471983	0.5	TSC2 TSC1	Cellular senescence
WP:WP481	0.0255965717397	0.5	TSC2 TSC1	Insulin signaling
KEGG:04140	0.0298999303213	0.5	TSC2 TSC1	Autophagy - animal
HP:0100012	0.03008608933	0.5	TSC2 TSC1	Neoplasm of the eye
HP:0100707	0.03008608933	0.5	TSC2 TSC1	Abnormal astrocyte morphology
REAC:R-HSA-5628897	0.0313666733646	0.5	TSC2 TSC1	TP53 Regulates Metabolic Genes
HP:0000238	0.0318501377451	0.75	TSC2 TSC1 TBC1D7	Hydrocephalus
HP:0009733	0.0329787201379	0.5	TSC2 TSC1	Glioma
HP:0000716	0.0343621225979	0.75	TSC2 TSC1 TBC1D7	Depression
HP:0033072	0.034474601612	0.5	TSC2 TSC1	Abnormal macroscopic urine appearance
HP:0002113	0.0375654511359	0.5	TSC2 TSC1	Pulmonary infiltrates
GO:1903432	0.0378152735667	0.75	TSC2 TSC1 TBC1D7	regulation of TORC1 signaling
HP:0000113	0.0391604009626	0.5	TSC2 TSC1	Polycystic kidney dysplasia
HP:0002893	0.040788355352	0.5	TSC2 TSC1	Pituitary adenoma
HP:0002539	0.0424493051949	0.5	TSC2 TSC1	Cortical dysplasia
GO:0038202	0.0434703685672	0.75	TSC2 TSC1 TBC1D7	TORC1 signaling
KEGG:05163	0.0451972531521	0.5	TSC2 TSC1	Human cytomegalovirus infection
HP:0002097	0.0458701548093	0.5	TSC2 TSC1	Emphysema
CORUM:6532	0.049938562206	0.25	TSC2	TSC2-HERC1 complex
CORUM:7158	0.049938562206	0.25	TSC2	TSC2-DVL complex

Edges

Protein 1	Protein 2	Score	ProteomeHD	Evidence
TSC1	TBC1D7	1.0	0.19	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TSC2	TBC1D7	0.999	0.228	hein_WMM bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM hein () bioplex3_HCT116
TSC2	TSC1	0.999	0.412	hein_WMM bioplex_WMM bioplex3_WMM hein () boldt_WMM
TBC1D7	KIF27	0.991		bioplex3_HEK293 bioplex () bioplex_WMM bioplex3_WMM
TSC1	KIF27	0.378		bioplex_WMM bioplex3_WMM WMM_only
TSC2	KIF27	0.163		bioplex_WMM bioplex3_WMM WMM_only

Related Complexes

Genename	Complexes
TSC1	huMAP3_04821.1 huMAP3_13140.1
TBC1D7	huMAP3_04821.1 huMAP3_13140.1
KIF27	huMAP3_04821.1 huMAP3_13140.1
TSC2	huMAP3_03753.1 huMAP3_04821.1

hu.MAP 3.0: Complex View

Search for a protein

Complex: huMAP3_04821.1

Complex Portal: CPX-14245